COPD Trials / Trials in Pennsylvania
29 Recruiting Trials

Clinical Trials
for COPD in Pennsylvania

29 clinical trials for COPD are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.

29
Recruiting trials
43
Study sites
14
Cities
20
Industry-sponsored
10
Phase 2
9
Phase 3

COPD clinical trials in Pennsylvania: what to expect

COPD trials test new inhaler combinations, biologic injections for people whose flare-ups continue despite inhalers, and treatments for the cough and mucus that come with chronic bronchitis. Others study pulmonary rehabilitation and exercise, valves and other procedures for emphysema, home oxygen and remote monitoring, and programs to stop smoking. Most enroll people with moderate to severe disease who still have symptoms on their current treatment.

In Pennsylvania, recruiting copd studies are concentrated in Philadelphia, DuBois, Pittsburgh and Camp Hill, with sites in 10 other cities. 20 of the 29 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COPD trials usually look for

Trials confirm COPD with a breathing test at screening and set a range for lung function, usually between 30 and 80 percent of predicted. Most ask for a smoking history of at least ten pack-years, though current smokers are generally accepted. Biologic trials require one or two flare-ups in the past year needing steroids or antibiotics and sometimes a blood eosinophil count above a threshold. Common exclusions are asthma as the main diagnosis, another significant lung disease and a flare-up in the past four weeks. Ages are usually 40 to 80.

What taking part involves

Screening includes spirometry, blood work and a symptom questionnaire, then a short run-in while you record symptoms. Drug trials run six to twelve months with visits every four to twelve weeks, breathing tests, a six-minute walk in some, and a diary or app. Your maintenance inhalers continue, sometimes replaced by study-supplied versions, and rescue inhaler is always allowed. Rehabilitation trials involve two or three sessions a week for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your inhalers stay the same; how breathing tests and walking tests are scheduled; the chance of placebo; what to do during a flare-up while enrolled; and whether oxygen users are accepted.

Showing 20 of 29 recruiting COPD trials in Pennsylvania

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD
PHASE2 Pittsburgh, Pennsylvania +2 sites NCT05270525
This trial is looking for people with COPD who smoke or have a history of smoking. Participants will take either ensifentrine or a placebo for two 8-week periods and attend several clinic visits over 24 weeks.
Recruiting
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
NA Philadelphia, Pennsylvania +3 sites NCT07222410
This trial is looking for people with COPD who are in the hospital and need extra oxygen. Participants will use the Airvo 3 device to help keep their oxygen levels stable.
Recruiting
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
NA Birmingham, Alabama +4 sites NCT07051707
This trial is looking for adults with chronic obstructive pulmonary disease (COPD) who have been receiving standard medical care. Participants will undergo a one-time procedure to help improve their breathing.
Recruiting
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NA Birmingham, Alabama +4 sites NCT05204888
This trial is looking for people with moderate to very severe COPD who have had a recent severe worsening of their condition. Participants will use the myAirvo 3 device at home while receiving their usual COPD care for at least one year.
Recruiting
Leveraging Lung Cancer Screening to Optimize Screening Outcomes and COPD Management: COPD in LCS Registry
N/A Philadelphia, Pennsylvania NCT06974981
This trial is looking for people aged 50-80 who have COPD and are being screened for lung cancer. Participants will provide health information, including symptoms and past imaging results, while being observed over time.
Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
PHASE3 Birmingham, Alabama +4 sites NCT06878261
This trial is looking for adults aged 40 to 80 who have had COPD for at least a year. Participants will take the study drug Tezepelumab and be monitored for its effects on their condition.
Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
PHASE3 Foley, Alabama +4 sites NCT06883305
This trial is looking for adults with moderate to very severe COPD. Participants will be required to take part in assessments and treatments involving Tezepelumab.
Recruiting
Multi-Center Clean Air Randomized Controlled Trial in COPD
PHASE3 Birmingham, Alabama +4 sites NCT06376994
This trial is looking for people with chronic obstructive pulmonary disease (COPD) to see if using an air cleaner can help them. Participants will be asked questions about their health and will have an air cleaner placed in their home to test its effectiveness.
Recruiting
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment
PHASE2 Phoenix, Arizona +4 sites NCT07684820
This trial is looking for people with chronic obstructive pulmonary disease (COPD) who have had recent flare-ups of their condition. Participants will take either the study drug or a placebo every day for a year.
Recruiting
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
PHASE2 Los Angeles, California +4 sites NCT07646587
This trial is looking for adults with moderate to severe COPD to test a new medication called WIN378. Participants will take the medicine and have their lung function and safety monitored.
Recruiting
Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD
PHASE2 Birmingham, Alabama +4 sites NCT07059091
This trial is looking for individuals with Chronic Obstructive Pulmonary Disease (COPD) and allergies. Participants will take a medication called omalizumab for about a year and have follow-up calls afterwards.
Recruiting
COPD Exacerbation Follow Up
N/A Philadelphia, Pennsylvania +4 sites NCT07118306
This trial is looking for people who are 40 or older and have COPD. Participants will help evaluate an AI tool designed to improve follow-up care after a severe worsening of their condition.
Recruiting
SPIROMICS Study of Early COPD Progression (SOURCE)
N/A Birmingham, Alabama +4 sites NCT05033990
This trial is looking for people aged 30-55 to study early chronic obstructive pulmonary disease (COPD). Participants will undergo tests like breathing tests and provide samples to help researchers understand who is at risk of developing COPD.
Recruiting
Temple Health Chest Initiative (THCI 2.0)
N/A Philadelphia, Pennsylvania NCT06933758
This trial is looking for people aged 50 to 80 who have been screened for early lung cancer using low dose CT imaging. Participants will help study how chronic obstructive pulmonary disease (COPD) is related to lung cancer screening.
Recruiting
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
NA Birmingham, Alabama +4 sites NCT06891755
This trial is looking for adults with COPD and emphysema who experience difficulty breathing. Participants will receive a device to help open their airways and will be followed for three years.
Recruiting
Supporting Evidence-based Responses to Emotional Needs in Emphysema
NA Philadelphia, Pennsylvania +1 sites NCT06600126
This trial is looking for adults with COPD who want to improve their emotional well-being. Participants will take part in either a training program to help cope with stress or an education program about COPD over 12 weeks.
Recruiting
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
PHASE3 Athens, Alabama +4 sites NCT06283966
This trial is looking for adults aged 40 to 80 with Chronic Obstructive Pulmonary Disease (COPD). Participants will receive a combination inhaler treatment and attend study visits for assessments.
Recruiting
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
PHASE2 Birmingham, Alabama +4 sites NCT07082738
This trial is looking for people with moderate to very severe COPD to test the effects of a new drug called AZD6793. Participants will take AZD6793 or a placebo and help researchers learn about its safety and effectiveness.
Recruiting
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
PHASE2 Birmingham, Alabama +4 sites NCT07363694
This trial is looking for adults aged 35 to 80 with moderate to severe COPD. Participants will receive either the study medicine PF-07275315 or a placebo through shots over 24 to 68 weeks and will attend multiple clinic visits during this time.
Recruiting
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
PHASE3 Chandler, Arizona +4 sites NCT07190209
This trial is looking for adults aged 40 to 80 with chronic obstructive pulmonary disease (COPD) that isn't well controlled. Participants will receive either lunsekimig or a placebo for approximately 48 weeks, followed by an 8-week follow-up.
Recruiting
See all 29 COPD trials in Pennsylvania

Where the COPD studies are in Pennsylvania

Research sites running the most studies
  • Temple University, Philadelphia5 trials
  • Clinical Research Associates of Central PA, LLC, DuBois3 trials
  • Research Site, DuBois3 trials
  • Research Site, Philadelphia3 trials
  • Clinical Research Associates of Central Pennsylvania, DuBois2 trials
  • GSK Investigational Site, DuBois2 trials
By city

Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.

COPD clinical trials in Pennsylvania: common questions

How many COPD clinical trials are recruiting in Pennsylvania?
TrialFinder currently lists 29 recruiting COPD clinical trials with study sites in Pennsylvania. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COPD clinical trials located in Pennsylvania?
Study sites for the COPD trials listed on this page include Pittsburgh, Philadelphia. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COPD clinical trial in Pennsylvania?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COPD trials in Pennsylvania also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COPD clinical trial in Pennsylvania?
Each study sets its own criteria based on age, COPD diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to quit smoking to join a COPD trial?
Most COPD trials accept current smokers; some require that you have stopped, and smoking-cessation trials are specifically for people who still smoke. The listing states the rule.
What tests confirm COPD for a trial?
Spirometry, a breathing test done at the site before and after a bronchodilator, which gives the lung function figure trials use to set their range. You do not need recent results to ask.
Will I keep using my inhalers during a trial?
Yes. Trials add the study treatment to your maintenance inhalers or supply a standardized equivalent, and a rescue inhaler is always permitted.
COPD Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COPD Trials

COPD trials investigate bronchodilators, anti-inflammatory biologics, pulmonary rehabilitation, and lung-volume reduction procedures for chronic obstructive lung disease.

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Other Conditions in Pennsylvania
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