Clinical Trials
for Depression in Pennsylvania
40 clinical trials for Depression are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.
Depression clinical trials in Pennsylvania: what to expect
Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.
In Pennsylvania, recruiting depression studies are concentrated in Philadelphia, Pittsburgh, Hershey and Allentown, with sites in 34 other cities. 9 of the 40 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who depression trials usually look for
Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.
Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.
What taking part involves
Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.
Questions worth asking the study team
Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.
Showing 20 of 40 recruiting Depression trials in Pennsylvania
Where the Depression studies are in Pennsylvania
- University of Pittsburgh, Pittsburgh8 trials
- Children's Hospital of Philadelphia, Philadelphia3 trials
- University of Pennsylvania, Philadelphia3 trials
- Draig Clinical Site, Media2 trials
- Neuronetics, Malvern2 trials
- Abramson Cancer Center at the University of Pennsylvania, Philadelphia1 trial
Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.
Depression clinical trials in Pennsylvania: common questions
Check Your Eligibility
Create a free profile and our AI will match you to Depression trials near you in Pennsylvania.
Get Matched — FreeDepression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.
All Depression trials →