Depression Trials / Trials in Arkansas
11 Recruiting Trials

Clinical Trials
for Depression in Arkansas

11 clinical trials for Depression are currently recruiting participants at study sites in Arkansas. Study-related care is provided at no cost.

11
Recruiting trials
18
Study sites
10
Cities
9
Industry-sponsored
5
Phase 2
5
Phase 3

Depression clinical trials in Arkansas: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Arkansas, recruiting depression studies are concentrated in Little Rock, Bentonville, Rogers and Bryant, with sites in 6 other cities. 9 of the 11 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 11 of 11 recruiting Depression trials in Arkansas

Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
PHASE3 Little Rock, Arkansas +4 sites NCT06372964
This trial is looking for young people aged 10 to 17 who have bipolar depression. Participants will receive either the study medication or a placebo while their mood is monitored.
Recruiting
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
PHASE2 Little Rock, Arkansas +4 sites NCT06524830
This trial is looking for adults with treatment resistant depression. Participants will receive either a new treatment called VLS-01 Buccal Film or a placebo to see how effective it is.
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
PHASE3 Bentonville, Arkansas +4 sites NCT04777357
This trial is looking for young people aged 10 to 17 who have bipolar I disorder and are experiencing depressive episodes. Participants will receive either a study drug called cariprazine or a placebo to see how it affects their mood.
Recruiting
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
PHASE3 Little Rock, Arkansas +4 sites NCT07172516
This trial is looking for adults aged 18 to 74 who are currently experiencing a depressive episode connected to bipolar disorder. Participants will receive either azetukalner or a placebo to see how well it works and its safety.
Recruiting
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
PHASE2 Little Rock, Arkansas +4 sites NCT07610473
This trial is looking for adults with Major Depressive Disorder who have had at least one previous episode of depression. Participants will receive either the study drug DT-101 or a placebo, and attend the clinic for health checks and questionnaires.
Recruiting
ALTO-100 in Bipolar Disorder With Depression (BD-D)
PHASE2 Fayetteville, Arkansas +4 sites NCT06656416
This trial is looking for adults who have bipolar disorder along with a current major depressive episode and are already taking a mood stabilizer. It’s important that they haven't changed their medication in the last two weeks and are not pregnant or breastfeeding. They can't have other serious health issues, be currently using certain medications, or have a history of severe substance use problems.
Recruiting
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
PHASE2 Bentonville, Arkansas +4 sites NCT07300969
This trial is looking for adults with recurrent depression to see if DT-101 can help. Participants will visit the clinic every couple of weeks for health checks and to complete questionnaires.
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
PHASE2 Bryant, Arkansas +4 sites NCT06696755
This trial is looking for adults with bipolar I or II disorder to test the drug Icalcaprant. Participants will take capsules daily for 6 weeks and have follow-up visits to monitor their health and side effects.
Recruiting
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
PHASE3 Little Rock, Arkansas +4 sites NCT06793397
This trial is looking for adults with major depressive disorder to see if CYB003 is effective and safe. Participants will take either the drug or a placebo while continuing their current antidepressant medication.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Fort Smith, Arkansas +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
NA Little Rock, Arkansas +4 sites NCT06923423
This trial is looking for adults in prison who have experienced trauma and have a substance use disorder. Participants will receive group therapy focused on trauma or use a self-help workbook while incarcerated.
Recruiting
See all 11 Depression trials in Arkansas

Where the Depression studies are in Arkansas

Research sites running the most studies
  • Draig Clinical Site, Little Rock2 trials
  • Pillar Clinical Research, LLC, Little Rock2 trials
  • University of Arkansas for Medical Sciences, Little Rock2 trials
  • Woodland Research Northwest, Rogers2 trials
  • 6039, Fayetteville1 trial
  • 6070, Little Rock1 trial
By city

Counts are recruiting studies listing at least one site in Arkansas, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Arkansas: common questions

How many Depression clinical trials are recruiting in Arkansas?
TrialFinder currently lists 11 recruiting Depression clinical trials with study sites in Arkansas. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Arkansas?
Study sites for the Depression trials listed on this page include Little Rock, Bentonville, Fayetteville, Bryant, Fort Smith. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Arkansas?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Arkansas also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Arkansas?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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