Depression Trials / Trials in New Hampshire
4 Recruiting Trials

Clinical Trials
for Depression in New Hampshire

4 clinical trials for Depression are currently recruiting participants at study sites in New Hampshire. Study-related care is provided at no cost.

4
Recruiting trials
10
Study sites
5
Cities
1
Industry-sponsored

Depression clinical trials in New Hampshire: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In New Hampshire, recruiting depression studies are concentrated in Lebanon, Nashua, Concord and Hanover, with sites in 1 other city. 1 of the 4 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 4 of 4 recruiting Depression trials in New Hampshire

Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression
NA Hanover, New Hampshire +1 sites NCT07174557
This trial is looking for adults who have recently been treated for depression and are feeling well. Participants will help researchers understand if smartphone data can predict if depression symptoms return.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
Internet Based Psychological Support
NA Lebanon, New Hampshire NCT02726061
This trial is looking for adults with depression who are employees or faculty at DHMC or Dartmouth College. Participants will engage in online programs to help with problem-solving, stress management, and conflict resolution.
Recruiting
Enhancing Engagement by Integrating Goals and Concerns That Matter to Patients
NA Concord, New Hampshire +4 sites NCT06898593
This trial is looking for adults with anxiety or depression who are part of a specific care program at Dartmouth Health. Participants will fill out a questionnaire before their care appointments to help improve treatment and engagement.
Recruiting
See all 4 Depression trials in New Hampshire

Where the Depression studies are in New Hampshire

Research sites running the most studies
  • Dartmouth College, Hanover1 trial
  • Dartmouth Hitchcock Concord Family Medicine, Concord1 trial
  • Dartmouth Hitchcock Manchester Family Practice, Manchester1 trial
  • Dartmouth Hitchcock Medical Center, Lebanon1 trial
  • Dartmouth Hitchcock Nashua Family Practice, Nashua1 trial
  • Dartmouth Hitchcock Nashua General Internal Medicine, Nashua1 trial
By city

Counts are recruiting studies listing at least one site in New Hampshire, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in New Hampshire: common questions

How many Depression clinical trials are recruiting in New Hampshire?
TrialFinder currently lists 4 recruiting Depression clinical trials with study sites in New Hampshire. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in New Hampshire?
Study sites for the Depression trials listed on this page include Hanover, Lebanon, Concord. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in New Hampshire?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in New Hampshire also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in New Hampshire?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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