Depression Trials / Trials in Mississippi
4 Recruiting Trials

Clinical Trials
for Depression in Mississippi

4 clinical trials for Depression are currently recruiting participants at study sites in Mississippi. Study-related care is provided at no cost.

4
Recruiting trials
10
Study sites
7
Cities
3
Industry-sponsored
2
Phase 2
1
Phase 3

Depression clinical trials in Mississippi: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Mississippi, recruiting depression studies are concentrated in Flowood, Jackson, Columbus and Grenada, with sites in 3 other cities. 3 of the 4 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 4 of 4 recruiting Depression trials in Mississippi

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
ALTO-100 in Bipolar Disorder With Depression (BD-D)
PHASE2 Birmingham, Alabama +4 sites NCT06656416
This trial is looking for adults who have bipolar disorder along with a current major depressive episode and are already taking a mood stabilizer. It’s important that they haven't changed their medication in the last two weeks and are not pregnant or breastfeeding. They can't have other serious health issues, be currently using certain medications, or have a history of severe substance use problems.
Recruiting
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
PHASE2 Bentonville, Arkansas +4 sites NCT07300969
This trial is looking for adults with recurrent depression to see if DT-101 can help. Participants will visit the clinic every couple of weeks for health checks and to complete questionnaires.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
See all 4 Depression trials in Mississippi

Where the Depression studies are in Mississippi

Research sites running the most studies
  • Andrew Bishop, MD, Jackson1 trial
  • Baptist Cancer Center-Grenada, Grenada1 trial
  • Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven1 trial
  • Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus1 trial
  • Baptist Memorial Hospital and Cancer Center-Oxford, Oxford1 trial
  • Baptist Memorial Hospital and Cancer Center-Union County, New Albany1 trial
By city

Counts are recruiting studies listing at least one site in Mississippi, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Mississippi: common questions

How many Depression clinical trials are recruiting in Mississippi?
TrialFinder currently lists 4 recruiting Depression clinical trials with study sites in Mississippi. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Mississippi?
Sites for these Depression trials are spread across Mississippi. Open any trial to see its full list of participating locations and contact details.
Do I need insurance to join a Depression clinical trial in Mississippi?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Mississippi also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Mississippi?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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Other Conditions in Mississippi
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