Depression Trials / Trials in Arizona
16 Recruiting Trials

Clinical Trials
for Depression in Arizona

16 clinical trials for Depression are currently recruiting participants at study sites in Arizona. Study-related care is provided at no cost.

16
Recruiting trials
19
Study sites
6
Cities
10
Industry-sponsored
6
Phase 2
6
Phase 3

Depression clinical trials in Arizona: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Arizona, recruiting depression studies are concentrated in Phoenix, Tucson, Chandler and Flagstaff, with sites in 2 other cities. 10 of the 16 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 16 of 16 recruiting Depression trials in Arizona

Lumateperone for Late-Life Depression
PHASE3 Tucson, Arizona +1 sites NCT07623135
This trial is looking for older adults with depression that hasn't improved after trying other treatments. Participants will take either the medication lumateperone or a placebo pill to see how it helps their depression.
Recruiting
Brexanolone Lifting Outcomes Of Moms
PHASE3 Tucson, Arizona +4 sites NCT07822321
This trial is looking for women aged 15 to 45 who are experiencing severe postpartum depression. Participants will take the study drug LPCN 1154A to see if it helps reduce their depressive symptoms and to learn about any side effects.
Recruiting
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
PHASE2 Tucson, Arizona +4 sites NCT06524830
This trial is looking for adults with treatment resistant depression. Participants will receive either a new treatment called VLS-01 Buccal Film or a placebo to see how effective it is.
Recruiting
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
PHASE2 Phoenix, Arizona +4 sites NCT07553637
This trial is looking for adults aged 18 to 75 who have moderate to severe depression that hasn't improved with other treatments. Participants will compare the effects of ALTO-207 with a placebo.
Recruiting
Effects of Spirulina Supplementation on Mental Health in Healthy Adults
NA Phoenix, Arizona NCT06936202
This trial is looking for healthy adults aged 18 to 65. Participants will take 3g of spirulina daily for 8 weeks to see if it helps improve mood and mental clarity compared to a placebo.
Recruiting
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
PHASE3 Tucson, Arizona +4 sites NCT07172516
This trial is looking for adults aged 18 to 74 who are currently experiencing a depressive episode connected to bipolar disorder. Participants will receive either azetukalner or a placebo to see how well it works and its safety.
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
PHASE3 Tucson, Arizona +4 sites NCT07484217
This trial is looking for adults with major depressive disorder and excessive daytime sleepiness symptoms. Participants will first take solriamfetol openly, followed by a period where neither the participant nor the doctor knows if the treatment is the drug or a placebo.
Recruiting
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
PHASE2 Phoenix, Arizona +4 sites NCT07610473
This trial is looking for adults with Major Depressive Disorder who have had at least one previous episode of depression. Participants will receive either the study drug DT-101 or a placebo, and attend the clinic for health checks and questionnaires.
Recruiting
ALTO-100 in Bipolar Disorder With Depression (BD-D)
PHASE2 Chandler, Arizona +4 sites NCT06656416
This trial is looking for adults who have bipolar disorder along with a current major depressive episode and are already taking a mood stabilizer. It’s important that they haven't changed their medication in the last two weeks and are not pregnant or breastfeeding. They can't have other serious health issues, be currently using certain medications, or have a history of severe substance use problems.
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
PHASE2 Chandler, Arizona +4 sites NCT06696755
This trial is looking for adults with bipolar I or II disorder to test the drug Icalcaprant. Participants will take capsules daily for 6 weeks and have follow-up visits to monitor their health and side effects.
Recruiting
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
PHASE3 Gilbert, Arizona +4 sites NCT06793397
This trial is looking for adults with major depressive disorder to see if CYB003 is effective and safe. Participants will take either the drug or a placebo while continuing their current antidepressant medication.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
PHASE2 Phoenix, Arizona +4 sites NCT07621237
This trial is looking for adults with major depressive disorder to see if a new treatment called TNX-102 SL helps improve their symptoms. Participants will take the treatment or a placebo for 6 weeks and visit the clinic every two weeks for checkups.
Recruiting
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
NA Phoenix, Arizona +3 sites NCT06162741
This trial is looking for Veterans who experience anxiety, depression, or PTSD symptoms. Participants will take part in either a mindfulness class or a problem-solving skills class to see if these help reduce their symptoms.
Recruiting
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
NA Tucson, Arizona NCT07464860
This trial is looking for older adults who are scheduled for knee surgery within the next two months. Participants will practice breathing exercises to help manage pain and stress after their surgery.
Recruiting
Enhancing Health in Rural Populations: Music as Therapy
NA Flagstaff, Arizona +1 sites NCT07538427
This trial is looking for adults living in elder care facilities in northern Arizona to participate in music classes. People will attend weekly music sessions for six weeks and share their experiences through surveys and interviews.
Recruiting
See all 16 Depression trials in Arizona

Where the Depression studies are in Arizona

Research sites running the most studies
  • Noble Clinical Research, Tucson2 trials
  • 850 PBC, Phoenix1 trial
  • Chandler Clinical Research Trials /ID# 274500, Chandler1 trial
  • Clinical Research Site, Tucson1 trial
  • Del Sol Research Management - East Tanque Verde Road - Tucson /ID# 279767, Tucson1 trial
  • Draig Clinical Site, Phoenix1 trial
By city

Counts are recruiting studies listing at least one site in Arizona, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Arizona: common questions

How many Depression clinical trials are recruiting in Arizona?
TrialFinder currently lists 16 recruiting Depression clinical trials with study sites in Arizona. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Arizona?
Study sites for the Depression trials listed on this page include Tucson, Phoenix, Chandler, Gilbert, Flagstaff. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Arizona?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Arizona also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Arizona?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

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Other Conditions in Arizona
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