Depression Trials / Trials in Ohio
28 Recruiting Trials

Clinical Trials
for Depression in Ohio

28 clinical trials for Depression are currently recruiting participants at study sites in Ohio. Study-related care is provided at no cost.

28
Recruiting trials
54
Study sites
23
Cities
11
Industry-sponsored
9
Phase 2
5
Phase 3

Depression clinical trials in Ohio: what to expect

Depression trials cover new medicines, brain stimulation, talk therapy and digital programs. The busiest area is treatment-resistant depression: studies for people whose current antidepressant has not helped enough, testing rapid-acting medicines, add-on treatments and devices such as transcranial magnetic stimulation. Others compare types of therapy, test app-based programs, or study depression alongside another condition such as chronic pain or heart disease.

In Ohio, recruiting depression studies are concentrated in Columbus, Cincinnati, Cleveland and Garfield Heights, with sites in 19 other cities. 11 of the 28 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who depression trials usually look for

Most adult trials require a diagnosis of major depressive disorder, a current episode with symptoms above a threshold on a standard questionnaire, and ages 18 to 65. Treatment-resistant trials ask that one or two antidepressants at a proper dose have not worked in the current episode. Common exclusions are bipolar disorder, psychosis, a substance use disorder in the last year and, for safety, a high current suicide risk. Many trials let you continue stable talk therapy.

Some medicine trials add the study drug to the antidepressant you take; others require a supervised taper first. The listing says which.

What taking part involves

Screening is a structured interview with a clinician plus blood work. Medicine trials usually run six to twelve weeks with weekly or fortnightly visits and mood questionnaires, and many include a placebo arm, with close safety monitoring either way; an open-label extension often follows so everyone can receive the active drug. Therapy and app trials run eight to sixteen weeks and compare against usual care. Treatment, visits and tests are free, and most trials pay for time.

Questions worth asking the study team

Whether you would taper your current medicine and how that is supervised; the chance of placebo and whether there is an open-label extension; what happens if you feel worse during the study; and whether your own doctor is kept informed. Research records are kept separate from your medical record unless you ask otherwise.

Showing 20 of 28 recruiting Depression trials in Ohio

A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
PHASE2 Columbus, Ohio NCT06820723
This trial is looking for adults aged 21 to 65 who have depression and anxiety. Participants will take either a psilocybin-related drug or a placebo and undergo assessments to understand the effects on their symptoms and brain function.
Recruiting
Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth
PHASE3 Cincinnati, Ohio NCT07464886
This trial is looking for young people aged 15 to 24 who have mild depression and have not taken certain medications recently. Participants will be involved in treatments to help understand how brain functions relate to their mood.
Recruiting
Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
PHASE3 Dothan, Alabama +4 sites NCT06372964
This trial is looking for young people aged 10 to 17 who have bipolar depression. Participants will receive either the study medication or a placebo while their mood is monitored.
Recruiting
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
PHASE2 Tucson, Arizona +4 sites NCT06524830
This trial is looking for adults with treatment resistant depression. Participants will receive either a new treatment called VLS-01 Buccal Film or a placebo to see how effective it is.
Recruiting
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
PHASE2 Birmingham, Alabama +4 sites NCT07553637
This trial is looking for adults aged 18 to 75 who have moderate to severe depression that hasn't improved with other treatments. Participants will compare the effects of ALTO-207 with a placebo.
Recruiting
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NA Birmingham, Alabama +4 sites NCT03887715
This trial is looking for adults with treatment-resistant depression. Participants will receive either active VNS therapy or a control without stimulation to see how it affects their depression over 12 months.
Recruiting
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NA Birmingham, Alabama +4 sites NCT06423430
This trial is looking for adults with treatment resistant depression who have not improved with other treatments. Participants will receive a new type of brain stimulation as part of their care.
Recruiting
Observational Study of THC Concentrations in Acute Cannabis-induced CNS Depression
N/A Cincinnati, Ohio +2 sites NCT06017622
This trial is looking for children under 18 who show symptoms of cannabis-related brain depression after using cannabis. Participants will have blood samples taken during their visit to the emergency department to check THC levels.
Recruiting
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
PHASE3 Bentonville, Arkansas +4 sites NCT04777357
This trial is looking for young people aged 10 to 17 who have bipolar I disorder and are experiencing depressive episodes. Participants will receive either a study drug called cariprazine or a placebo to see how it affects their mood.
Recruiting
Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains
PHASE1 Mason, Ohio NCT06795451
This trial is looking for adults with major depressive disorder to test a new way to help manage their symptoms using a method called spinal cord stimulation. Participants will undergo treatments and complete assessments to see how well the method works.
Recruiting
Teenthrive 2: Treatments for Improving Mood in Teens
NA Columbus, Ohio +1 sites NCT07475845
Recruiting
The Mom and Infant Outcomes (MOMI) Study
NA Columbus, Ohio NCT06277661
This trial is looking for pregnant individuals who have certain health issues like high blood pressure or depression. By participating, I would receive care designed to help both me and my baby after pregnancy.
Recruiting
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
PHASE3 Tucson, Arizona +4 sites NCT07484217
This trial is looking for adults with major depressive disorder and excessive daytime sleepiness symptoms. Participants will first take solriamfetol openly, followed by a period where neither the participant nor the doctor knows if the treatment is the drug or a placebo.
Recruiting
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
PHASE2 Phoenix, Arizona +4 sites NCT07610473
This trial is looking for adults with Major Depressive Disorder who have had at least one previous episode of depression. Participants will receive either the study drug DT-101 or a placebo, and attend the clinic for health checks and questionnaires.
Recruiting
ALTO-100 in Bipolar Disorder With Depression (BD-D)
PHASE2 Birmingham, Alabama +4 sites NCT06656416
This trial is looking for adults who have bipolar disorder along with a current major depressive episode and are already taking a mood stabilizer. It’s important that they haven't changed their medication in the last two weeks and are not pregnant or breastfeeding. They can't have other serious health issues, be currently using certain medications, or have a history of severe substance use problems.
Recruiting
A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder
PHASE2 Huntsville, Alabama +4 sites NCT06696755
This trial is looking for adults with bipolar I or II disorder to test the drug Icalcaprant. Participants will take capsules daily for 6 weeks and have follow-up visits to monitor their health and side effects.
Recruiting
Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation
NA Cincinnati, Ohio NCT07217444
This trial is looking for teenagers with major depression who are currently hospitalized. Participants will receive a specific treatment called deep Transcranial Magnetic Stimulation (dTMS) in addition to their usual care.
Recruiting
Mechanisms of Rumination Change in Adolescent Depression
NA Columbus, Ohio +2 sites NCT03859297
This trial is looking for teenagers aged 14-17 with a history of depression. Participants will receive a new type of therapy that helps change negative thinking patterns, aiming to reduce the chances of depression returning.
Recruiting
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
N/A Orange, California +4 sites NCT07048574
This trial is looking for children aged 18 months to 11 years who have cystic fibrosis. Participation involves being followed by a care team and discussing mental health issues like depression and anxiety.
Recruiting
E-Mindfulness Approaches for Living After Breast Cancer
PHASE3 Phoenix, Arizona +4 sites NCT06748222
This trial is looking for younger women who have survived breast cancer and are experiencing depression. Participants will try two different mindfulness programs, one led by an instructor via Zoom and the other through a mobile app.
Recruiting
See all 28 Depression trials in Ohio

Where the Depression studies are in Ohio

Research sites running the most studies
  • The Ohio State University, Columbus5 trials
  • Case Western Reserve University, Cleveland2 trials
  • Charak Center for Health and Wellness, Garfield Heights2 trials
  • Nationwide Children's Hospital, Columbus2 trials
  • Ohio State University Comprehensive Cancer Center, Columbus2 trials
  • 6065, North Canton1 trial
By city

Counts are recruiting studies listing at least one site in Ohio, from ClinicalTrials.gov, refreshed every two days.

Depression clinical trials in Ohio: common questions

How many Depression clinical trials are recruiting in Ohio?
TrialFinder currently lists 28 recruiting Depression clinical trials with study sites in Ohio. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Depression clinical trials located in Ohio?
Study sites for the Depression trials listed on this page include Columbus, Cincinnati, Mason. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Depression clinical trial in Ohio?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Depression trials in Ohio also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Depression clinical trial in Ohio?
Each study sets its own criteria based on age, Depression diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I have to stop my antidepressant to join a depression trial?
Not always. Many trials add the study treatment to the antidepressant you already take; others ask for a supervised taper before starting. Each listing states which, and the study doctor manages any change.
Is there a placebo in depression trials?
Most medicine trials include a placebo arm, often with two active participants for every one on placebo, and usually followed by an extension where everyone receives the drug. Therapy, device and app trials generally compare against usual care instead.
Can I join if I am already seeing a therapist?
Usually yes for medicine trials, provided the therapy has been ongoing and stable. Trials of a specific therapy may ask you not to start a second one during the study.
Depression Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to Depression trials near you in Ohio.

Get Matched — Free
No insurance required
About Depression Trials

Depression trials investigate antidepressant medications, TMS, ketamine infusions, psychotherapy protocols, and digital mental-health interventions.

All Depression trials →
Other Conditions in Ohio
Diabetes Cancer Breast Cancer Anxiety Alzheimer's Heart Disease Asthma Multiple Sclerosis Obesity Parkinson's Lupus Hypertension COPD Stroke Arthritis Kidney Disease COVID-19
All trials in Ohio →