COVID-19 Trials / Trials in Ohio
17 Recruiting Trials

Clinical Trials
for COVID-19 in Ohio

17 clinical trials for COVID-19 are currently recruiting participants at study sites in Ohio. Study-related care is provided at no cost.

17
Recruiting trials
26
Study sites
9
Cities
11
Industry-sponsored
2
Phase 2
10
Phase 3

COVID-19 clinical trials in Ohio: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

In Ohio, recruiting covid-19 studies are concentrated in Columbus, Cincinnati, Cleveland and Mayfield Heights, with sites in 5 other cities. 11 of the 17 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 17 of 17 recruiting COVID-19 trials in Ohio

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
PHASE3 Cullman, Alabama +4 sites NCT06667700
This trial is looking for adults at high risk for severe illness from COVID-19. Participants will take the study drug molnupiravir or a placebo and monitor their health over time.
Recruiting
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
PHASE3 Huntsville, Alabama +4 sites NCT06679140
This trial is looking for teens aged 12 to 17 who weigh at least 40 kg and adults aged 18 and older, especially those at risk of getting seriously ill from COVID-19. Participants should have recently tested positive for COVID-19 and show some symptoms, but they shouldn’t be in need of hospitalization. People with certain serious health issues or those who are very sick right now won't be able to join.
Recruiting
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
PHASE3 Canoga Park, California +4 sites NCT07013474
This trial is looking for adults who are severely immunocompromised and have COVID-19. Participants will receive either ibuzatrelvir alone or with another medication to see how well it works against the virus.
Recruiting
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
PHASE3 Phoenix, Arizona +4 sites NCT05261139
This trial is looking for young patients under 18 years old who have COVID-19 but are not hospitalized, and may be at risk for more severe illness. Participants will be given a medicine called nirmatrelvir/ritonavir to help treat their condition.
Recruiting
Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19
PHASE4 Fair Oaks, California +4 sites NCT07861542
This trial is looking for older adults and younger individuals with health conditions that increase their risk of severe COVID-19. Participants will receive a single injection and have follow-up calls over three months.
Recruiting
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
NA Columbus, Ohio +4 sites NCT05218083
This trial is looking for people who have been seriously ill with COVID-19 and are ready to go home from the hospital. Participants will receive support for a physical rehabilitation program that includes exercise sessions monitored through mobile health technology.
Recruiting
A Study of COVID-19 Vaccine(s) in Children and Adults
PHASE3 Homestead, Florida +4 sites NCT07798648
This trial is looking for children and adults who are at risk for serious COVID-19. Participants will receive a COVID-19 vaccine injection and report any side effects over about 6 months.
Recruiting
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
PHASE3 Jacksonville, Florida +4 sites NCT02735707
This trial is looking for adults in intensive care with severe community-acquired pneumonia. Participants will receive various treatments to see what helps them improve.
Recruiting
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
N/A Phoenix, Arizona +4 sites NCT04278404
This trial is looking for children and young adults who are 21 years old or younger and are currently taking certain medications, or who have had a recent COVID-19 infection. They cannot be pregnant or have had certain recent medical procedures like dialysis, organ transplants, or other serious treatments. If you think your child might fit this description, it could be worth considering.
Recruiting
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
PHASE3 Duarte, California +4 sites NCT03808922
This trial is looking for immunocompromised patients who have a lower respiratory tract infection due to parainfluenza. Participants will receive treatment with DAS181 and need to meet specific health criteria.
Recruiting
SARS-CoV-2 CTLS for Mild to Moderate COVID-19 Disease
PHASE1 Columbus, Ohio +3 sites NCT04896606
This trial is looking for individuals aged 18 to 65 who have mild to moderate COVID-19. Participants will receive a treatment derived from a family member who has recovered from COVID-19.
Recruiting
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
PHASE2 Columbus, Ohio +4 sites NCT05123755
This trial is looking for patients in the hospital with pneumonia who need extra oxygen. If you join, you will receive either the AV-001 Injection or a placebo each day until you leave the hospital or for up to 28 days.
Recruiting
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
NA Cleveland, Ohio NCT04858412
This trial is looking for patients who have both alcoholic liver disease and COVID-19 pneumonia. Participants will receive a supplement called HMB to see if it helps improve their condition and recovery.
Recruiting
A Study of Secutrelvir in Participants With Coronavirus Disease 2019 (COVID-19) Who Are at High Risk for Progression to Severe Disease
PHASE3 Coral Gables, Florida +4 sites NCT07743580
This trial is looking for teenagers and adults who have mild COVID-19 symptoms and are at high risk of getting severely ill. Participants will take secutrelvir and help researchers understand how well it works and its safety.
Recruiting
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
PHASE3 Birmingham, Alabama +4 sites NCT05624450
This trial is looking for adults who are hospitalized with a viral lung infection and need extra oxygen. Participants will receive treatment with tozorakimab along with their usual care to see if it helps prevent worsening conditions.
Recruiting
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
PHASE3 Tucson, Arizona +4 sites NCT06631287
This trial is looking for adults with Long COVID symptoms that have lasted at least 6 months. Participants will compare the effects of the medication baricitinib with a placebo on their symptoms and quality of life.
Recruiting
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
N/A Birmingham, Alabama +4 sites NCT03452774
This trial is looking for cancer patients to see if an AI tool can help match them to clinical trials. Patients will have their cancer-related biomarkers evaluated to find suitable studies for their condition.
Recruiting
See all 17 COVID-19 trials in Ohio

Where the COVID-19 studies are in Ohio

Research sites running the most studies
  • The Ohio State University Wexner Medical Center, Columbus2 trials
  • Cincinnati Children's Hospital Medical Center, Cincinnati1 trial
  • Cincinnati Childrens Hospital Medical Center, Cincinnati1 trial
  • Cleveland Clinic Foundation, Cleveland1 trial
  • Dayton Clinical Research, Dayton1 trial
  • Hometown Urgent Care and Research, Cincinnati1 trial
By city

Counts are recruiting studies listing at least one site in Ohio, from ClinicalTrials.gov, refreshed every two days.

COVID-19 clinical trials in Ohio: common questions

How many COVID-19 clinical trials are recruiting in Ohio?
TrialFinder currently lists 17 recruiting COVID-19 clinical trials with study sites in Ohio. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in Ohio?
Study sites for the COVID-19 trials listed on this page include Columbus, Cleveland. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COVID-19 clinical trial in Ohio?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in Ohio also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in Ohio?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COVID-19 Trials

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

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