COVID-19 Trials / Trials in South Dakota
2 Recruiting Trials

Clinical Trials
for COVID-19 in South Dakota

2 clinical trials for COVID-19 are currently recruiting participants at study sites in South Dakota. Study-related care is provided at no cost.

2
Recruiting trials
3
Study sites
1
City
1
Industry-sponsored
1
Phase 3

COVID-19 clinical trials in South Dakota: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

In South Dakota, recruiting covid-19 studies are concentrated in Sioux Falls. 1 of the 2 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 2 of 2 recruiting COVID-19 trials in South Dakota

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
PHASE3 Phoenix, Arizona +4 sites NCT05261139
This trial is looking for young patients under 18 years old who have COVID-19 but are not hospitalized, and may be at risk for more severe illness. Participants will be given a medicine called nirmatrelvir/ritonavir to help treat their condition.
Recruiting
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
N/A Phoenix, Arizona +4 sites NCT04278404
This trial is looking for children and young adults who are 21 years old or younger and are currently taking certain medications, or who have had a recent COVID-19 infection. They cannot be pregnant or have had certain recent medical procedures like dialysis, organ transplants, or other serious treatments. If you think your child might fit this description, it could be worth considering.
Recruiting
See all 2 COVID-19 trials in South Dakota

Where the COVID-19 studies are in South Dakota

Research sites running the most studies
  • Avera McKennan Hospital & University Health Center, Sioux Falls1 trial
  • Avera McKennan Hospital & University Medical Center, Sioux Falls1 trial
  • Avera Research Institute - Sioux Falls, Sioux Falls1 trial
By city

Counts are recruiting studies listing at least one site in South Dakota, from ClinicalTrials.gov, refreshed every two days.

COVID-19 clinical trials in South Dakota: common questions

How many COVID-19 clinical trials are recruiting in South Dakota?
TrialFinder currently lists 2 recruiting COVID-19 clinical trials with study sites in South Dakota. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in South Dakota?
Sites for these COVID-19 trials are spread across South Dakota. Open any trial to see its full list of participating locations and contact details.
Do I need insurance to join a COVID-19 clinical trial in South Dakota?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in South Dakota also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in South Dakota?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to COVID-19 trials near you in South Dakota.

Get Matched — Free
No insurance required
About COVID-19 Trials

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

All COVID-19 trials →
Other Conditions in South Dakota
Diabetes Cancer Breast Cancer Depression Anxiety Alzheimer's Heart Disease Asthma Multiple Sclerosis Obesity Parkinson's Lupus Hypertension COPD Stroke Arthritis Kidney Disease
All trials in South Dakota →