COVID-19 Trials / Trials in Massachusetts
16 Recruiting Trials

Clinical Trials
for COVID-19 in Massachusetts

16 clinical trials for COVID-19 are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.

16
Recruiting trials
16
Study sites
4
Cities
5
Industry-sponsored
1
Phase 2
5
Phase 3

COVID-19 clinical trials in Massachusetts: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

In Massachusetts, recruiting covid-19 studies are concentrated in Boston, Worcester, Lexington and New Bedford. 5 of the 16 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 16 of 16 recruiting COVID-19 trials in Massachusetts

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
PHASE3 Phoenix, Arizona +4 sites NCT05261139
This trial is looking for young patients under 18 years old who have COVID-19 but are not hospitalized, and may be at risk for more severe illness. Participants will be given a medicine called nirmatrelvir/ritonavir to help treat their condition.
Recruiting
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
PHASE3 Huntsville, Alabama +4 sites NCT06679140
This trial is looking for teens aged 12 to 17 who weigh at least 40 kg and adults aged 18 and older, especially those at risk of getting seriously ill from COVID-19. Participants should have recently tested positive for COVID-19 and show some symptoms, but they shouldn’t be in need of hospitalization. People with certain serious health issues or those who are very sick right now won't be able to join.
Recruiting
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
PHASE3 Canoga Park, California +4 sites NCT07013474
This trial is looking for adults who are severely immunocompromised and have COVID-19. Participants will receive either ibuzatrelvir alone or with another medication to see how well it works against the virus.
Recruiting
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
PHASE1 Boston, Massachusetts +4 sites NCT07536308
This trial is looking for healthy adults aged 18-64 who have already been vaccinated against COVID-19. Participants will receive a single dose of the OCU500 vaccine through either the nose or inhaled method.
Recruiting
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
N/A Phoenix, Arizona +4 sites NCT04278404
This trial is looking for children and young adults who are 21 years old or younger and are currently taking certain medications, or who have had a recent COVID-19 infection. They cannot be pregnant or have had certain recent medical procedures like dialysis, organ transplants, or other serious treatments. If you think your child might fit this description, it could be worth considering.
Recruiting
Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
N/A Boston, Massachusetts NCT05866952
This trial is looking for adults who have had COVID-19 and are experiencing ongoing breathing problems or fatigue. Participants will undergo scans to evaluate their lung function and circulation.
Recruiting
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
PHASE3 Duarte, California +4 sites NCT03808922
This trial is looking for immunocompromised patients who have a lower respiratory tract infection due to parainfluenza. Participants will receive treatment with DAS181 and need to meet specific health criteria.
Recruiting
Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India
N/A Boston, Massachusetts +1 sites NCT06168019
This trial is looking for pregnant women in their first trimester to study the effects of COVID-19 and influenza on pregnancy and newborn health. Participants will provide information about their health and undergo some tests at a hospital in Nagpur, India.
Recruiting
Mind Body Intervention for Long COVID-19
NA Boston, Massachusetts NCT06045338
This trial is looking for adults with symptoms from Long COVID to see if a mind-body program can help. Participants will compare this program with regular care and another similar treatment.
Recruiting
Defibrotide for the Treatment of Severe COVID-19
PHASE2 Boston, Massachusetts NCT04652115
This trial is looking for adults with severe COVID-19 who have pneumonia. Participants will receive defibrotide to see if it's safe and helpful for this condition.
Recruiting
Testimonials and Navigation in Rheumatology
NA Boston, Massachusetts +2 sites NCT06469788
This trial is looking for adults with autoimmune diseases who identify as Black or Latinx and have not received the updated COVID-19 vaccine. Participants will engage in a support program at rheumatology clinics to help them get vaccinated.
Recruiting
Sauna for Long Covid
NA Boston, Massachusetts NCT05931497
This trial is looking for adults aged 18 to 65 who have experienced symptoms of Long COVID for at least 12 weeks. Participants will spend time in a sauna-like environment to see if it helps reduce their symptoms.
Recruiting
COVID-19 Transmission and Morbidity in Malawi
N/A Boston, Massachusetts +1 sites NCT05973084
This trial is looking for people in Malawi who have COVID-19 or are close to someone who does. Participants will help researchers understand how infections and vaccines work in the community.
Recruiting
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
PHASE3 Tucson, Arizona +4 sites NCT06631287
This trial is looking for adults with Long COVID symptoms that have lasted at least 6 months. Participants will compare the effects of the medication baricitinib with a placebo on their symptoms and quality of life.
Recruiting
Positron Emission Tomography (PET) Imaging of Thrombosis
PHASE1 Boston, Massachusetts NCT03830320
This trial is looking for patients with conditions like cancer, COVID-19, or atrial fibrillation to help test a new imaging method for detecting blood clots in the body. Participants will undergo a special imaging procedure using a tracer called 64Cu-FBP8.
Recruiting
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
N/A Birmingham, Alabama +4 sites NCT03452774
This trial is looking for cancer patients to see if an AI tool can help match them to clinical trials. Patients will have their cancer-related biomarkers evaluated to find suitable studies for their condition.
Recruiting
See all 16 COVID-19 trials in Massachusetts

Where the COVID-19 studies are in Massachusetts

Research sites running the most studies
  • Brigham and Women's Hospital, Boston6 trials
  • University of Massachusetts Chan Medical School, Worcester4 trials
  • BU School of Public Health, Global Health Department, Boston1 trial
  • Beth Israel Deaconess Medical Center, Boston1 trial
  • Boston Children's Hospital, Boston1 trial
  • Boston Medical Center, Boston1 trial
By city

Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.

COVID-19 clinical trials in Massachusetts: common questions

How many COVID-19 clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 16 recruiting COVID-19 clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in Massachusetts?
Study sites for the COVID-19 trials listed on this page include Boston. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COVID-19 clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in Massachusetts?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COVID-19 Trials

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

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