Arthritis Trials / Trials in Massachusetts
29 Recruiting Trials

Clinical Trials
for Arthritis in Massachusetts

29 clinical trials for Arthritis are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.

29
Recruiting trials
30
Study sites
13
Cities
14
Industry-sponsored
6
Phase 2
6
Phase 3

Arthritis clinical trials in Massachusetts: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Massachusetts, recruiting arthritis studies are concentrated in Boston, Waltham, New Bedford and Cambridge, with sites in 9 other cities. 14 of the 29 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 20 of 29 recruiting Arthritis trials in Massachusetts

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
PHASE3 Phoenix, Arizona +4 sites NCT07153471
This trial is looking for people who are 50 years or older and have osteoarthritis in their knee along with being overweight or obese. They should have tried to lose weight before but haven’t had success. However, if you've lost or gained more than 11 pounds recently, have diabetes, or a serious heart condition, you won’t be able to join.
Recruiting
Purified Cortrophin® Gel Efficacy and Safety Study of 2 Dose Levels in Patients With Acute Gout Flares
PHASE4 Boston, Massachusetts NCT07346079
This trial is looking for adults with acute gout flares who want to test a treatment called Purified Cortrophin® Gel. Participants will receive one dose of the gel and follow up for a week to see how it works.
Recruiting
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
PHASE3 Mobile, Alabama +4 sites NCT07353931
This trial is looking for adults who are at least 50 years old and have knee pain from osteoarthritis, as well as being overweight or obese. It’s important that they haven't had a recent heart issue or surgery for weight loss, and they shouldn’t have diabetes. Participants also need to have tried losing weight through diet without success.
Recruiting
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
PHASE3 Glendale, Arizona +4 sites NCT06807424
This trial is looking for people with active psoriatic arthritis who have previously tried certain treatments but still have symptoms. Participants will take part in a study to see how well a medication called icotrokinra works compared to a placebo.
Recruiting
RA-PRO PRAGMATIC TRIAL
PHASE3 Auburn, Alabama +4 sites NCT04692493
This trial is looking for people with active rheumatoid arthritis who have not improved with their current treatment. Participants will have the chance to switch to a different type of medication to see if it helps their condition.
Recruiting
Preventing Injured Knees From osteoArthritis: Severity Outcomes
PHASE2 Boston, Massachusetts +4 sites NCT06096259
This trial is looking for people aged 18-45 who have had an ACL injury and are planning to have surgery. Participants will take either metformin or a placebo that looks like metformin to see if it helps reduce pain related to post-traumatic osteoarthritis.
Recruiting
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
PHASE2 Glendale, Arizona +4 sites NCT07276581
This trial is looking for people with moderately-to-severely active rheumatoid arthritis. Participants will be evaluated for how well the medication AZD1163 works and its safety.
Recruiting
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
PHASE2 Birmingham, Alabama +4 sites NCT07641517
This trial is looking for people with knee pain from osteoarthritis to test a new treatment. Participants will need to meet specific health criteria to join the study.
Recruiting
Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA
PHASE2 Charlestown, Massachusetts NCT05839535
This trial is looking for older adults with knee osteoarthritis who are physically able to participate in an exercise program. Participants will engage in exercises over 12 weeks and may have brain imaging done.
Recruiting
Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis
PHASE1 Scottsdale, Arizona +4 sites NCT06201416
This trial is looking for adults with moderate to severe rheumatoid arthritis who have not responded well to other treatments. Participants will receive a single dose of SBT777101 and will be monitored for safety and effects.
Recruiting
Remote Tai Chi for Knee Osteoarthritis
NA Boston, Massachusetts NCT06384898
This trial is looking for adults aged 50 and older who have knee osteoarthritis. Participants will either take part in online Tai Chi sessions twice a week for 12 weeks or continue with their regular care.
Recruiting
The Osteoarthritis Prevention Study
NA Boston, Massachusetts +3 sites NCT05946044
This trial is looking for adult women aged 50 and older who are obese but have little to no knee pain. Participants will engage in a program involving weight loss, exercise, and maintaining their weight to help prevent knee osteoarthritis.
Recruiting
Turmeric for Patients With Basal Joint Arthritis
NA Boston, Massachusetts NCT03017118
This trial is looking for adults aged 40 and over who have pain and stiffness in their thumbs due to basal joint arthritis. Participants will take turmeric to see if it helps with their symptoms.
Recruiting
The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
N/A Boston, Massachusetts +2 sites NCT07315997
This trial is looking for people with rheumatoid arthritis who are between 40 and 79 years old. Participants will help researchers find better ways to identify those at risk of heart disease.
Recruiting
Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.
NA Boston, Massachusetts +4 sites NCT05796908
This trial is looking for people with joint pain in the arm caused by unstable radial head issues. Participants will undergo a procedure using the Aptis PRUJ prosthesis and will need to follow post-surgery care guidelines.
Recruiting
Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
PHASE3 Worcester, Massachusetts +4 sites NCT05669833
This trial is looking for people with psoriatic arthritis who haven't had enough improvement from their current treatment. Participants will switch to one of the two medications being studied to see which works better.
Recruiting
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
PHASE2 Birmingham, Alabama +4 sites NCT05986292
This trial is looking for people with chronic pain from conditions like osteoarthritis or diabetic neuropathic pain. Participants will undergo treatments while being monitored for their pain levels.
Recruiting
Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain
NA Springfield, Massachusetts NCT07674901
This trial is looking for older adults with knee pain who want to see if using a knee sleeve every day helps their condition. Participants will use a knee sleeve or not use one, and their progress will be monitored over 5 years.
Recruiting
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
N/A Newton, Massachusetts +3 sites NCT07199738
This trial is looking for adults aged 18 to 80 who need knee replacement surgery due to arthritis or related issues. It’s important that your health is stable, so they cannot accept people with certain serious conditions or those who are severely overweight. They also want to exclude anyone who has had recent surgery on the other knee or has specific allergies.
Recruiting
Innovations in Genicular Outcomes Registry
N/A Phoenix, Arizona +4 sites NCT05495334
This trial is looking for patients who have knee osteoarthritis and are planning to receive treatments for their pain, such as injections or surgery. Participants will provide information about their experiences and treatments through an app.
Recruiting
See all 29 Arthritis trials in Massachusetts

Where the Arthritis studies are in Massachusetts

Research sites running the most studies
  • Brigham and Women's Hospital, Boston5 trials
  • Massachusetts General Hospital, Boston5 trials
  • MedVadis Research Corporation, Waltham3 trials
  • Tufts University, Boston3 trials
  • Lucida Clinical Trials, New Bedford2 trials
  • Tufts Medical Center, Boston2 trials
By city

Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Massachusetts: common questions

How many Arthritis clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 29 recruiting Arthritis clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Massachusetts?
Study sites for the Arthritis trials listed on this page include Boston, Charlestown, Worcester, Springfield, Newton. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Massachusetts?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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