Arthritis Trials / Trials in Virginia
17 Recruiting Trials

Clinical Trials
for Arthritis in Virginia

17 clinical trials for Arthritis are currently recruiting participants at study sites in Virginia. Study-related care is provided at no cost.

17
Recruiting trials
16
Study sites
10
Cities
10
Industry-sponsored
2
Phase 2
6
Phase 3

Arthritis clinical trials in Virginia: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Virginia, recruiting arthritis studies are concentrated in Charlottesville, Newport News, Richmond and Virginia Beach, with sites in 6 other cities. 10 of the 17 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 17 of 17 recruiting Arthritis trials in Virginia

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
PHASE3 Phoenix, Arizona +4 sites NCT07153471
This trial is looking for people who are 50 years or older and have osteoarthritis in their knee along with being overweight or obese. They should have tried to lose weight before but haven’t had success. However, if you've lost or gained more than 11 pounds recently, have diabetes, or a serious heart condition, you won’t be able to join.
Recruiting
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
PHASE3 Mobile, Alabama +4 sites NCT07353931
This trial is looking for adults who are at least 50 years old and have knee pain from osteoarthritis, as well as being overweight or obese. It’s important that they haven't had a recent heart issue or surgery for weight loss, and they shouldn’t have diabetes. Participants also need to have tried losing weight through diet without success.
Recruiting
RA-PRO PRAGMATIC TRIAL
PHASE3 Auburn, Alabama +4 sites NCT04692493
This trial is looking for people with active rheumatoid arthritis who have not improved with their current treatment. Participants will have the chance to switch to a different type of medication to see if it helps their condition.
Recruiting
Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain
PHASE3 Roseville, California +4 sites NCT07226258
This trial is looking for adults with chronic knee pain due to osteoarthritis. Participants will receive a single dose of SL1002 to evaluate its effects.
Recruiting
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
PHASE2 Avondale, Arizona +4 sites NCT07137598
This trial is looking for people with moderate to severe rheumatoid arthritis who haven't had good results with previous treatments or can't tolerate them. Participants will receive either the study drug or a placebo to see how it helps with their condition.
Recruiting
Ketogenic and Carnivore (Lion) Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis
NA Charlottesville, Virginia NCT07524244
This trial is looking for adults with inflammatory bowel disease or rheumatoid arthritis. Participants will follow either a ketogenic diet or a carnivore diet for 24 weeks, reporting on their symptoms and quality of life throughout the study.
Recruiting
MISHA Post-Market Clinical Study
NA Charlottesville, Virginia +3 sites NCT06118892
This trial is looking for adults with knee osteoarthritis who are experiencing pain and have not found relief from other treatments. Participants will be monitored for up to five years after receiving the MISHA Knee System.
Recruiting
Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain
NA Charlottesville, Virginia NCT06872567
This trial is looking for people with localized knee pain to compare a new procedure called genicular artery embolization to traditional steroid injections. Participants will need to be suitable for an artery procedure and willing to meet the study requirements.
Recruiting
Effects of Gait Retraining on Lower Extremity Biomechanics
NA Manassas, Virginia NCT03663790
This trial is looking for people with knee osteoarthritis. Participants will go through gait retraining sessions to see if it helps their knee movement and pain.
Recruiting
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
PHASE2 Tuscaloosa, Alabama +4 sites NCT06991114
This trial is looking for adults with certain autoimmune diseases, like rheumatoid arthritis or systemic sclerosis, who haven't responded well to standard treatments. It's important that they've had these conditions diagnosed recently and have tried other medicines without success. People with other serious health issues or who are pregnant may not be able to participate.
Recruiting
Optimizing Pain Self-Management in Total Knee Arthroplasty
NA Charlottesville, Virginia NCT06038240
This trial is looking for adults who are planning to have knee surgery due to osteoarthritis. Participants will either practice savoring meditation or take part in a different pain management education program, and there will be follow-up assessments to see how effective they are.
Recruiting
Z1 Hip System: Post-Market Clinical Follow Up Study
N/A Alexandria, Virginia +4 sites NCT07104279
Recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
N/A Laguna Woods, California +4 sites NCT05603728
This trial is looking for people who may need shoulder surgery or have had it before. Participants will be followed for at least 10 years to see how well the surgery works over time.
Recruiting
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
PHASE3 Escondido, California +4 sites NCT07509307
This trial is looking for people with excess weight and knee osteoarthritis. Participants will receive an injection either of the study medicine or a placebo once a week for a set period of time.
Recruiting
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
PHASE3 Phoenix, Arizona +4 sites NCT07481630
This trial is looking for adults with knee osteoarthritis and extra body weight. Participants will receive either an injection of NNC0487-0111 or a placebo once a week to see how it helps with weight loss and pain reduction.
Recruiting
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
N/A Birmingham, Alabama +4 sites NCT02418442
This trial is looking for children and teenagers with rheumatic joint diseases. If you join, you will help researchers gather important information about treatments used for these conditions.
Recruiting
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
PHASE1 Birmingham, Alabama +4 sites NCT03816345
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
Recruiting
See all 17 Arthritis trials in Virginia

Where the Arthritis studies are in Virginia

Research sites running the most studies
  • Charlottesville Medical Research, Charlottesville2 trials
  • Health Res of Hampton Roads, Newport News2 trials
  • University of Virginia, Charlottesville2 trials
  • Anderson Orthopaedic/Anderson Orthopaedic Research Institute, Alexandria1 trial
  • Artiva Investigational Site Roanoke, Roanoke1 trial
  • Atlantic Orthopaedics Specialists, Virginia Beach1 trial
By city

Counts are recruiting studies listing at least one site in Virginia, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Virginia: common questions

How many Arthritis clinical trials are recruiting in Virginia?
TrialFinder currently lists 17 recruiting Arthritis clinical trials with study sites in Virginia. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Virginia?
Study sites for the Arthritis trials listed on this page include Charlottesville, Manassas, Alexandria. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Virginia?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Virginia also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Virginia?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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