Arthritis Trials / Trials in Michigan
31 Recruiting Trials

Clinical Trials
for Arthritis in Michigan

31 clinical trials for Arthritis are currently recruiting participants at study sites in Michigan. Study-related care is provided at no cost.

31
Recruiting trials
33
Study sites
15
Cities
20
Industry-sponsored
12
Phase 2
7
Phase 3

Arthritis clinical trials in Michigan: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Michigan, recruiting arthritis studies are concentrated in Ann Arbor, Detroit, Lansing and Grand Blanc, with sites in 11 other cities. 20 of the 31 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 20 of 31 recruiting Arthritis trials in Michigan

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines
PHASE3 Chandler, Arizona +4 sites NCT06671483
This trial is looking for adults with psoriatic arthritis who have not taken biologic medicines. Participants will receive either the study drug, a comparator, or a placebo over a period of up to 60 weeks.
Recruiting
RA-PRO PRAGMATIC TRIAL
PHASE3 Auburn, Alabama +4 sites NCT04692493
This trial is looking for people with active rheumatoid arthritis who have not improved with their current treatment. Participants will have the chance to switch to a different type of medication to see if it helps their condition.
Recruiting
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
PHASE3 Avondale, Arizona +4 sites NCT06641089
This trial is looking for adults with active psoriatic arthritis who did not respond well to past treatments. Participants will take sonelokimab or a placebo to see how well it works and if it is safe.
Recruiting
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines
PHASE3 Mesa, Arizona +4 sites NCT06671496
This trial is looking for adults with psoriatic arthritis to test the drug zasocitinib. Participants will receive either zasocitinib or a placebo for up to 60 weeks.
Recruiting
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
PHASE2 Avondale, Arizona +4 sites NCT07137598
This trial is looking for people with moderate to severe rheumatoid arthritis who haven't had good results with previous treatments or can't tolerate them. Participants will receive either the study drug or a placebo to see how it helps with their condition.
Recruiting
Intra-Articular Allocetra in Patients With Primary Knee Osteoarthritis
PHASE2 Troy, Michigan +4 sites NCT07580716
This trial is looking for older adults with knee osteoarthritis who have not found relief from previous treatments. Participants will receive injections to see if it helps reduce their knee pain.
Recruiting
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
PHASE2 Peoria, Arizona +4 sites NCT06972446
This trial is looking for patients with rheumatoid arthritis who have not responded to certain treatments. Participants will try new medications and attend regular check-ups to monitor their health.
Recruiting
Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
PHASE2 Ann Arbor, Michigan NCT04992624
This trial is looking for people with knee osteoarthritis who have chronic pain. Participants will take daily doses of CBD, THC, or a combination, and undergo various assessments along with treatment.
Recruiting
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
PHASE2 Birmingham, Alabama +4 sites NCT07641517
This trial is looking for people with knee pain from osteoarthritis to test a new treatment. Participants will need to meet specific health criteria to join the study.
Recruiting
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
PHASE2 Birmingham, Alabama +4 sites NCT06884865
This trial is looking for people aged 45 to 80 who have been dealing with knee pain from osteoarthritis for at least a year and have tried other treatments that didn’t work. They’re also looking for individuals who don’t have certain autoimmune diseases or infections and haven't had specific knee treatments in the last six months.
Recruiting
A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)
PHASE2 Gilbert, Arizona +4 sites NCT07409103
This trial is looking for people with active rheumatoid arthritis who haven't responded well to standard treatments. Participants will receive either the experimental drug ELV001 or a placebo for about 32 weeks.
Recruiting
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
PHASE1 Peoria, Arizona +4 sites NCT07290036
This trial is looking for adults with active psoriatic arthritis or axial spondyloarthritis. Participants will receive bimekizumab, which can be given in different ways, to see how safe it is and how it moves in the body over time.
Recruiting
Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis
NA Ann Arbor, Michigan NCT06580561
This trial is looking for older adults with knee osteoarthritis who also have trouble sleeping. Participants will receive personalized exercise coaching along with support to improve their sleep.
Recruiting
Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis
N/A Ann Arbor, Michigan NCT00748254
This trial is looking for individuals with rheumatoid arthritis to test a new technology for detecting the condition. Participants will need a referral from their doctor and must meet specific health criteria.
Recruiting
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
PHASE2 Birmingham, Alabama +4 sites NCT05986292
This trial is looking for people with chronic pain from conditions like osteoarthritis or diabetic neuropathic pain. Participants will undergo treatments while being monitored for their pain levels.
Recruiting
Dynamic Treatment Regiments for Glucocorticoid Tapering
PHASE2 Ann Arbor, Michigan +1 sites NCT06072768
This trial is looking for people with rheumatoid arthritis who want to learn more about safely lowering their steroid medication doses. Participants will take part in a study that involves making dose changes and reporting their experiences.
Recruiting
Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty
PHASE4 Grosse Pointe Farms, Michigan NCT07775248
Recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
N/A Laguna Woods, California +4 sites NCT05603728
This trial is looking for people who may need shoulder surgery or have had it before. Participants will be followed for at least 10 years to see how well the surgery works over time.
Recruiting
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
N/A Ann Arbor, Michigan +3 sites NCT06397677
This trial is looking for people with Rheumatoid Arthritis who have lung disease. Participants will help researchers understand how the disease progresses by providing information about their condition.
Recruiting
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
PHASE3 Escondido, California +4 sites NCT07509307
This trial is looking for people with excess weight and knee osteoarthritis. Participants will receive an injection either of the study medicine or a placebo once a week for a set period of time.
Recruiting
See all 31 Arthritis trials in Michigan

Where the Arthritis studies are in Michigan

Research sites running the most studies
  • University of Michigan, Ann Arbor8 trials
  • Great Lakes Research Group, Inc., Bay City2 trials
  • AA Medical Research Center - Grand Blanc /ID# 272496, Grand Blanc1 trial
  • Advanced Rheumatology PC | Lansing, MI, Lansing1 trial
  • American Arthritis and Rheumatology Associates -Mi PLLC, Okemos1 trial
  • Arcturus Healthcare, PLC., Troy1 trial
By city

Counts are recruiting studies listing at least one site in Michigan, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Michigan: common questions

How many Arthritis clinical trials are recruiting in Michigan?
TrialFinder currently lists 31 recruiting Arthritis clinical trials with study sites in Michigan. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Michigan?
Study sites for the Arthritis trials listed on this page include Troy, Ann Arbor, Grosse Pointe Farms. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Michigan?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Michigan also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Michigan?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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