Arthritis Trials / Trials in Maryland
24 Recruiting Trials

Clinical Trials
for Arthritis in Maryland

24 clinical trials for Arthritis are currently recruiting participants at study sites in Maryland. Study-related care is provided at no cost.

24
Recruiting trials
23
Study sites
5
Cities
14
Industry-sponsored
7
Phase 2
7
Phase 3

Arthritis clinical trials in Maryland: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Maryland, recruiting arthritis studies are concentrated in Baltimore, Bethesda, Hagerstown and Rockville, with sites in 1 other city. 14 of the 24 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 20 of 24 recruiting Arthritis trials in Maryland

Natural History and Development of Spondyloarthritis
N/A Bethesda, Maryland NCT01422694
This trial is looking for people diagnosed with spondyloarthritis and their healthy relatives. Participants will undergo tests to help understand the condition better, but no treatment will be provided.
Recruiting
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines
PHASE3 Chandler, Arizona +4 sites NCT06671483
This trial is looking for adults with psoriatic arthritis who have not taken biologic medicines. Participants will receive either the study drug, a comparator, or a placebo over a period of up to 60 weeks.
Recruiting
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
PHASE3 Glendale, Arizona +4 sites NCT06807424
This trial is looking for people with active psoriatic arthritis who have previously tried certain treatments but still have symptoms. Participants will take part in a study to see how well a medication called icotrokinra works compared to a placebo.
Recruiting
RA-PRO PRAGMATIC TRIAL
PHASE3 Auburn, Alabama +4 sites NCT04692493
This trial is looking for people with active rheumatoid arthritis who have not improved with their current treatment. Participants will have the chance to switch to a different type of medication to see if it helps their condition.
Recruiting
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
PHASE3 Avondale, Arizona +4 sites NCT06641089
This trial is looking for adults with active psoriatic arthritis who did not respond well to past treatments. Participants will take sonelokimab or a placebo to see how well it works and if it is safe.
Recruiting
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines
PHASE3 Mesa, Arizona +4 sites NCT06671496
This trial is looking for adults with psoriatic arthritis to test the drug zasocitinib. Participants will receive either zasocitinib or a placebo for up to 60 weeks.
Recruiting
Continuation Study of Zasocitinib in Adults With Psoriatic Arthritis
PHASE3 Tucson, Arizona +4 sites NCT07286058
This trial is looking for adults aged 18 and older who have completed a previous study involving a specific treatment for psoriatic arthritis. To join, you should have shown some positive results from that treatment and not have any other serious health issues that could confuse the results of the study. If your symptoms have worsened or if you’ve developed other skin problems, you won’t be eligible to participate.
Recruiting
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
PHASE2 Chandler, Arizona +4 sites NCT07133633
This trial is looking for people with a type of arthritis called radiographic axial spondyloarthritis. Participants will take a medication called tulisokibart to see if it helps improve their symptoms compared to a placebo, which looks like the medication but doesn’t contain any active ingredients.
Recruiting
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
PHASE2 Glendale, Arizona +4 sites NCT07276581
This trial is looking for people with moderately-to-severely active rheumatoid arthritis. Participants will be evaluated for how well the medication AZD1163 works and its safety.
Recruiting
Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)
PHASE2 Sun City, Arizona +4 sites NCT07486960
This trial is looking for adults with Psoriatic Arthritis who are experiencing active symptoms. Participants will take a study medicine called tulisokibart or a placebo to see if it helps reduce their symptoms better than the placebo.
Recruiting
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
PHASE2 Birmingham, Alabama +4 sites NCT06884865
This trial is looking for people aged 45 to 80 who have been dealing with knee pain from osteoarthritis for at least a year and have tried other treatments that didn’t work. They’re also looking for individuals who don’t have certain autoimmune diseases or infections and haven't had specific knee treatments in the last six months.
Recruiting
Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis
PHASE2 Huntington Beach, California +4 sites NCT06865105
This trial is looking for adults with active psoriatic arthritis to assess new treatments. Participants will receive either one of the treatments or a combination, with regular visits to check their health.
Recruiting
Platelet Rich Plasma Versus Corticosteroids in Hip Osteoarthritis Pain
PHASE4 Baltimore, Maryland NCT06793982
This trial is looking for adults with hip osteoarthritis. Participants will receive either a platelet-rich plasma injection or a corticosteroid injection to help reduce their pain and improve function.
Recruiting
ConsideRAte Study - Splenic Stimulation for RA
NA Hagerstown, Maryland +4 sites NCT05003310
This trial is looking for people with rheumatoid arthritis that hasn’t improved with other treatments. Participants will receive stimulation therapy using a special device to see if it helps their condition.
Recruiting
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
PHASE2 Bethesda, Maryland NCT07151417
Recruiting
Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare
PHASE2 Peoria, Arizona +4 sites NCT07145229
This trial is looking for adults who have experienced multiple gout flares. Participants will take ABP-745 or standard treatment to see if it helps reduce pain and swelling during an acute gout flare.
Recruiting
The Pericapsular Nerve Block in Total Hip Arthroplasty
PHASE4 Baltimore, Maryland NCT04729686
This trial is looking for patients needing total hip surgery and managing pain. Participants will receive either a pericapsular nerve block or a fascia iliaca nerve block to compare their effectiveness.
Recruiting
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
NA Baltimore, Maryland NCT04814082
Recruiting
Innovations in Genicular Outcomes Registry
N/A Phoenix, Arizona +4 sites NCT05495334
This trial is looking for patients who have knee osteoarthritis and are planning to receive treatments for their pain, such as injections or surgery. Participants will provide information about their experiences and treatments through an app.
Recruiting
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
N/A Bethesda, Maryland NCT03510442
This trial is looking for people with known or suspected systemic juvenile idiopathic arthritis (sJIA) or adult-onset Still's disease (AOSD). Participants will have tests and evaluations to help researchers learn more about these conditions over time.
Recruiting
See all 24 Arthritis trials in Maryland

Where the Arthritis studies are in Maryland

Research sites running the most studies
  • National Institutes of Health Clinical Center, Bethesda5 trials
  • Sinai Hospital of Baltimore, Baltimore4 trials
  • Arthritis and Rheumatism Associates - Rockville ( Site 0019), Rockville1 trial
  • Arthritis and Rheumatism Associates - Rockville ( Site 5127), Rockville1 trial
  • Clinical Site, Baltimore1 trial
  • Henry M Jackson Foundation for the Advancement of Military Medicine/Walter Reed National Military Medical Center, Bethesda1 trial
By city

Counts are recruiting studies listing at least one site in Maryland, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Maryland: common questions

How many Arthritis clinical trials are recruiting in Maryland?
TrialFinder currently lists 24 recruiting Arthritis clinical trials with study sites in Maryland. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Maryland?
Study sites for the Arthritis trials listed on this page include Bethesda, Baltimore, Hagerstown. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Maryland?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Maryland also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Maryland?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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