No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
1 Day – 100
Sex
Any
Study type
Observational
Participants needed
2,000 (estimated)
Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · NIH
Who this trial is looking for
This trial is looking for people with known or suspected systemic juvenile idiopathic arthritis (sJIA) or adult-onset Still's disease (AOSD). Participants will have tests and evaluations to help researchers learn more about these conditions over time.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with systemic juvenile idiopathic arthritis (sJIA)
I have been diagnosed with adult-onset Still's disease (AOSD)
I have symptoms of sJIA or AOSD
I am a family member of someone with sJIA or AOSD
I am participating as a control for research
I am under 16 and meet the criteria for sJIA
I am 16 or older and have previously met the criteria for sJIA
I am 16 or older and meet the criteria for AOSD
You may not be able to join if
I cannot provide informed consent
I have a medical condition that would confuse the study results
I cannot keep the follow-up visit schedule
I am pregnant
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Background:
Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD). Their causes are unknown. Researchers want to learn more about these conditions. This includes genetic changes and environmental factors.
Objective:
To study sJIA and AOSD in children and adul…
Background:
Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD). Their causes are unknown. Researchers want to learn more about these conditions. This includes genetic changes and environmental factors.
Objective:
To study sJIA and AOSD in children and adults over time.
Eligibility:
People with known or suspected sJIA, AOSD, or similar inflammatory condition
Design:
Participants will be screened with a phone call.
Participants will have 1 visit. It may be outpatient or they may be admitted to the clinic. The visit may last up to 5 days. Participants will have:
* Medical history
* Physical exam
* Musculoskeletal exam
* Questions about overall health and quality of life, disease activity, functional status, and cognitive ability.
Participants may also have:
* Pictures taken of their skin, joints, or spine
* Blood, urine, and stool tests
* Scans or X-rays of joints with arthritis
* Chest X-ray
* Heart tests
* Skin biopsy. The skin will be numbed. The top layers of a small area will be scraped off.
Participants who have a joint aspiration may provide a fluid sample. The joint will be prepared, then fluid is removed by needle. A corticosteroid may be injected.
Participants who have a bone marrow biopsy may provide sample cells.
Participants may be seen by NIH specialists.
Members of the participant s family and healthy volunteers may give blood or saliva samples for genetic testing.
Participants may repeat some study tests every 6 months.
Trial Locations
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Status
Eligibility Criteria
* INCLUSION CRITERIA:
Affected subject:
* Patients with signs and symptoms of sJIA will be classified as outlined in Diagnosis/Classification Criteria.
1. Patients less than 16 years of age will be considered to have sJIA if they meet the ILAR criteria for sJIA.
2. Patients 16 years of age an…
* INCLUSION CRITERIA:
Affected subject:
* Patients with signs and symptoms of sJIA will be classified as outlined in Diagnosis/Classification Criteria.
1. Patients less than 16 years of age will be considered to have sJIA if they meet the ILAR criteria for sJIA.
2. Patients 16 years of age and older will be considered to have sJIA if they have previously met ILAR criteria for sJIA.
* Patients with signs and symptoms of AOSD will be classified as outlined in Yamaguchi Criteria for diagnosing Adult-Onset Still's Disease.
1. Patients 16 years of age and older will be considered to have AOSD if they meet the Yamaguchi criteria for AOSD (including a negative ANA and RF).
2. Patients may be considered to have a diagnosis of AOSD if they met criteria for diagnosis in the past but do not still have present evidence of disease.
3. Pregnant people with still's disease are allowed to enroll. Pregnant people will not be asked to submit to a skin biopsy or bone marrow aspiration.
* The minimum age for participation in this study is between 0 and older.
Healthy Subjects:
1. Healthy Volunteers related to individuals included under items 1 and 2 above will be enrolled.
2. Unrelated healthy volunteers will be enrolled for clinical, cellular, molecular, and biochemical assays, and genetic evaluation. Individuals who undergo phlebotomy specifically to provide a control specimen will include both pediatric and adult patients and will not be pregnant.
3. Healthy Volunteer should not have any history of autoimmune, autoinflammatory, rheumatic or proliferative/malignant disease or any unexplained inflammatory signs/symptoms or conditions (applies to unrelated).
* The minimum age for participation in this study under this cohort is 2 years.
EXCLUSION CRITERIA:
Affected and Healthy subjects:
1. In adults, inability, or the lack of capacity to provide informed consent. In the case of minors, unavailability of a parent or guardian.
2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study.
3. Unavailability, or inability to adhere with the schedule for follow-up visits
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