27 Recruiting Trials
Clinical Trials
for Arthritis in Tennessee
27 clinical trials for Arthritis are currently recruiting participants at study sites in Tennessee. Study-related care is provided at no cost.
27
Recruiting trials
29
Study sites
11
Cities
19
Industry-sponsored
6
Phase 2
7
Phase 3
Arthritis clinical trials in Tennessee: what to expect
Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.
In Tennessee, recruiting arthritis studies are concentrated in Jackson, Nashville, Memphis and Murfreesboro, with sites in 7 other cities. 19 of the 27 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who arthritis trials usually look for
Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.
What taking part involves
Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.
Questions worth asking the study team
Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.
Showing 20 of 27 recruiting Arthritis trials in Tennessee
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Recruiting
This trial is looking for people who are 50 years or older and have osteoarthritis in their knee along with being overweight or obese. They should have tried to lose weight before but haven’t had success. However, if you've lost or gained more than 11 pounds recently, have diabetes, or a serious heart condition, you won’t be able to join.
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines
Recruiting
This trial is looking for adults with psoriatic arthritis who have not taken biologic medicines. Participants will receive either the study drug, a comparator, or a placebo over a period of up to 60 weeks.
RA-PRO PRAGMATIC TRIAL
Recruiting
This trial is looking for people with active rheumatoid arthritis who have not improved with their current treatment. Participants will have the chance to switch to a different type of medication to see if it helps their condition.
Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response
Recruiting
This trial is looking for adults with active psoriatic arthritis who did not respond well to past treatments. Participants will take sonelokimab or a placebo to see how well it works and if it is safe.
Continuation Study of Zasocitinib in Adults With Psoriatic Arthritis
Recruiting
This trial is looking for adults aged 18 and older who have completed a previous study involving a specific treatment for psoriatic arthritis. To join, you should have shown some positive results from that treatment and not have any other serious health issues that could confuse the results of the study. If your symptoms have worsened or if you’ve developed other skin problems, you won’t be eligible to participate.
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
Recruiting
This trial is looking for people with a type of arthritis called radiographic axial spondyloarthritis. Participants will take a medication called tulisokibart to see if it helps improve their symptoms compared to a placebo, which looks like the medication but doesn’t contain any active ingredients.
A Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic Arthritis
Recruiting
This trial is looking for adults with moderate to severe psoriatic arthritis. Participants will take a medication called DDY391 to see how well it works and if it's safe.
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
Recruiting
This trial is looking for patients with rheumatoid arthritis who have not responded to certain treatments. Participants will try new medications and attend regular check-ups to monitor their health.
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
Recruiting
This trial is looking for people aged 45 to 80 who have been dealing with knee pain from osteoarthritis for at least a year and have tried other treatments that didn’t work. They’re also looking for individuals who don’t have certain autoimmune diseases or infections and haven't had specific knee treatments in the last six months.
Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis
Recruiting
This trial is looking for adults with active psoriatic arthritis to assess new treatments. Participants will receive either one of the treatments or a combination, with regular visits to check their health.
A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
Recruiting
This trial is looking for people with active psoriatic arthritis who are overweight or obese. Participants will add a medication called tirzepatide to their current treatment with ixekizumab for up to 12 months.
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
Recruiting
This trial is looking for adults with active psoriatic arthritis or axial spondyloarthritis. Participants will receive bimekizumab, which can be given in different ways, to see how safe it is and how it moves in the body over time.
Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
Recruiting
This trial is looking for people with psoriatic arthritis who haven't had enough improvement from their current treatment. Participants will switch to one of the two medications being studied to see which works better.
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Recruiting
This trial is looking for adults with certain autoimmune diseases, like rheumatoid arthritis or systemic sclerosis, who haven't responded well to standard treatments. It's important that they've had these conditions diagnosed recently and have tried other medicines without success. People with other serious health issues or who are pregnant may not be able to participate.
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Recruiting
This trial is looking for people aged 50 or older who are having knee surgery due to osteoarthritis. Participants will receive a treatment that may help reduce pain after the surgery, and their progress will be checked for a year.
Exactech Shoulder Post Market Clinical Follow-up Study
Recruiting
This trial is looking for people who may need shoulder surgery or have had it before. Participants will be followed for at least 10 years to see how well the surgery works over time.
Innovations in Genicular Outcomes Registry
Recruiting
This trial is looking for patients who have knee osteoarthritis and are planning to receive treatments for their pain, such as injections or surgery. Participants will provide information about their experiences and treatments through an app.
Embo Registry; National Registry for Artery Embolization
Recruiting
This trial is looking for adults over 18 who have had artery embolization for chronic pain, especially from osteoarthritis or similar issues. Participants will help researchers understand how effective this treatment is for decreasing pain and improving quality of life.
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
Recruiting
This trial is looking for adults with systemic lupus erythematosus or rheumatoid arthritis. Participants will receive treatment and attend regular check-ups to assess the effects and safety of the drug.
Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis
Recruiting
This trial is looking for children with suspected joint infections to help find better ways to diagnose septic arthritis. Participants will have a special fluid test taken from their joints to check for infection or inflammation.
Where the Arthritis studies are in Tennessee
Research sites running the most studies
- West Tennessee Research Institute, Jackson3 trials
- Campbell Clinic, Germantown2 trials
- Campbell Clinic, Collierville2 trials
- AARA Clinical Research - Murfreesboro Medical Clinic, Murfreesboro1 trial
- AARA Clinical Research - Murfreesboro Medical Clinic ( Site 0029), Murfreesboro1 trial
- AMR Clinical, Knoxville1 trial
By city
Counts are recruiting studies listing at least one site in Tennessee, from ClinicalTrials.gov, refreshed every two days.
Arthritis clinical trials in Tennessee: common questions
How many Arthritis clinical trials are recruiting in Tennessee?
TrialFinder currently lists 27 recruiting Arthritis clinical trials with study sites in Tennessee. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Tennessee?
Study sites for the Arthritis trials listed on this page include Memphis, Nashville, Winchester, Collierville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Tennessee?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Tennessee also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Tennessee?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Arthritis Trials
Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.
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