Arthritis Trials / Trials in South Dakota
3 Recruiting Trials

Clinical Trials
for Arthritis in South Dakota

3 clinical trials for Arthritis are currently recruiting participants at study sites in South Dakota. Study-related care is provided at no cost.

3
Recruiting trials
3
Study sites
2
Cities
3
Industry-sponsored
1
Phase 3

Arthritis clinical trials in South Dakota: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In South Dakota, recruiting arthritis studies are concentrated in Sioux Falls and Rapid City. 3 of the 3 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 3 of 3 recruiting Arthritis trials in South Dakota

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
PHASE3 Phoenix, Arizona +4 sites NCT07153471
This trial is looking for people who are 50 years or older and have osteoarthritis in their knee along with being overweight or obese. They should have tried to lose weight before but haven’t had success. However, if you've lost or gained more than 11 pounds recently, have diabetes, or a serious heart condition, you won’t be able to join.
Recruiting
Safety of Adipose-derived Regenerative Cells Injection for Treatment of Osteoarthritis of the Facet Joint
NA Sioux Falls, South Dakota +1 sites NCT03513731
This trial is looking for adults with chronic lower back pain caused by osteoarthritis in the facet joints. Participants will receive an injection of adipose-derived regenerative cells to see if it helps their pain.
Recruiting
Perform Humeral System Study
N/A Lexington, Kentucky +4 sites NCT05067543
This trial is looking for adults with specific shoulder conditions who are considering shoulder surgery. Participants will help gather information about the safety and effectiveness of a particular device used in surgery.
Recruiting
See all 3 Arthritis trials in South Dakota

Where the Arthritis studies are in South Dakota

Research sites running the most studies
  • Care Access - Rapid City, Rapid City1 trial
  • Orthopedic Institute, Sioux Falls1 trial
  • Sanford Physical Medicine & Rehabilitation Clinic and Sanford Spine Center, Sioux Falls1 trial
By city

Counts are recruiting studies listing at least one site in South Dakota, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in South Dakota: common questions

How many Arthritis clinical trials are recruiting in South Dakota?
TrialFinder currently lists 3 recruiting Arthritis clinical trials with study sites in South Dakota. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in South Dakota?
Study sites for the Arthritis trials listed on this page include Sioux Falls. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in South Dakota?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in South Dakota also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in South Dakota?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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