Arthritis Trials / Trials in Iowa
7 Recruiting Trials

Clinical Trials
for Arthritis in Iowa

7 clinical trials for Arthritis are currently recruiting participants at study sites in Iowa. Study-related care is provided at no cost.

7
Recruiting trials
7
Study sites
2
Cities
3
Industry-sponsored
3
Phase 2

Arthritis clinical trials in Iowa: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Iowa, recruiting arthritis studies are concentrated in Iowa City and Des Moines. 3 of the 7 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 7 of 7 recruiting Arthritis trials in Iowa

Preventing Injured Knees From osteoArthritis: Severity Outcomes
PHASE2 Iowa City, Iowa +4 sites NCT06096259
This trial is looking for people aged 18-45 who have had an ACL injury and are planning to have surgery. Participants will take either metformin or a placebo that looks like metformin to see if it helps reduce pain related to post-traumatic osteoarthritis.
Recruiting
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
PHASE2 Tuscaloosa, Alabama +4 sites NCT06991114
This trial is looking for adults with certain autoimmune diseases, like rheumatoid arthritis or systemic sclerosis, who haven't responded well to standard treatments. It's important that they've had these conditions diagnosed recently and have tried other medicines without success. People with other serious health issues or who are pregnant may not be able to participate.
Recruiting
Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare
PHASE2 Des Moines, Iowa +4 sites NCT07145229
This trial is looking for adults who have experienced multiple gout flares. Participants will take ABP-745 or standard treatment to see if it helps reduce pain and swelling during an acute gout flare.
Recruiting
Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
NA Iowa City, Iowa NCT07180537
This trial is looking for adults with certain rheumatological conditions and mood disorders who want to improve their health through an online program. Participants will complete surveys and engage with the course for 6 months.
Recruiting
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
PHASE1 Iowa City, Iowa +4 sites NCT06916806
This trial is looking for adults with Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, or Rheumatoid Arthritis. Participants will receive the study drug AZD5492 either once or twice during the trial period and will attend several check-up visits over at least 180 days.
Recruiting
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
N/A Birmingham, Alabama +4 sites NCT02418442
This trial is looking for children and teenagers with rheumatic joint diseases. If you join, you will help researchers gather important information about treatments used for these conditions.
Recruiting
Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties
PHASE4 Iowa City, Iowa NCT05868330
This trial is looking for patients having shoulder replacement surgery to compare two types of pain relief methods. Participants will receive either a single injection or a catheter for pain management during recovery.
Recruiting
See all 7 Arthritis trials in Iowa

Where the Arthritis studies are in Iowa

Research sites running the most studies
  • Artiva Investigational Site Iowa, Iowa City1 trial
  • Exinia Research, Des Moines1 trial
  • Research Site, Iowa City1 trial
  • The University of Iowa Hospitals and Clinics (University of Iowa Children's Hospital), Iowa City1 trial
  • Univeristy of Iowa, Iowa City1 trial
  • University of Iowa Hospital and Clinics, Iowa City1 trial
By city

Counts are recruiting studies listing at least one site in Iowa, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Iowa: common questions

How many Arthritis clinical trials are recruiting in Iowa?
TrialFinder currently lists 7 recruiting Arthritis clinical trials with study sites in Iowa. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Iowa?
Study sites for the Arthritis trials listed on this page include Iowa City, Des Moines. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Iowa?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Iowa also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Iowa?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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Other Conditions in Iowa
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