Arthritis Trials / Trials in Alabama
19 Recruiting Trials

Clinical Trials
for Arthritis in Alabama

19 clinical trials for Arthritis are currently recruiting participants at study sites in Alabama. Study-related care is provided at no cost.

19
Recruiting trials
18
Study sites
5
Cities
13
Industry-sponsored
5
Phase 2
6
Phase 3

Arthritis clinical trials in Alabama: what to expect

Arthritis trials are split by type. Rheumatoid arthritis studies test biologics, targeted pills and, more recently, cell therapies in people whose joints stay inflamed despite methotrexate or a biologic. Knee osteoarthritis studies test injections meant to slow cartilage loss, new pain medicines, devices and exercise and weight programs. Psoriatic arthritis, ankylosing spondylitis and gout each have their own trials, and a listing will always say which type it enrolls.

In Alabama, recruiting arthritis studies are concentrated in Birmingham, Anniston, Auburn and Mobile, with sites in 1 other city. 13 of the 19 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who arthritis trials usually look for

Rheumatoid arthritis trials count swollen and tender joints and measure inflammation in the blood at screening, and ask that a standard medicine has not worked well enough; methotrexate usually continues, while a current biologic is stopped after a washout. Knee osteoarthritis trials need an X-ray showing moderate damage, a pain score above a threshold, and no steroid or hyaluronic acid injection in the past few months; many set a weight limit. Ages are usually 18 to 80, and most trials exclude pregnancy and a recent serious infection.

What taking part involves

Screening includes a joint exam, blood work and X-rays or an MRI. Rheumatoid arthritis trials run six to twelve months with visits every four weeks for an injection or infusion and labs; placebo arms are common, with rescue rules so no one stays on an ineffective treatment for long. Osteoarthritis injection trials give one or a few injections at the site and follow you for six to twenty-four months with pain diaries and imaging. Exercise trials involve supervised sessions for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Which of your medicines continue; how long any washout is; the chance of placebo and the rescue rules; how imaging is scheduled; and whether an extension lets everyone receive the active treatment.

Showing 19 of 19 recruiting Arthritis trials in Alabama

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)
PHASE3 Birmingham, Alabama +4 sites NCT07219771
This trial is looking for men and women aged 40 to 80 who have knee pain from a condition called osteoarthritis and have had symptoms for at least six months. They need to be able to walk without help, and if they have extra fluid in their knee, that would need to be removed first. If you have severe obesity or pain in your other knee, this might not be the right study for you.
Recruiting
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
PHASE3 Mobile, Alabama +4 sites NCT07353931
This trial is looking for adults who are at least 50 years old and have knee pain from osteoarthritis, as well as being overweight or obese. It’s important that they haven't had a recent heart issue or surgery for weight loss, and they shouldn’t have diabetes. Participants also need to have tried losing weight through diet without success.
Recruiting
RA-PRO PRAGMATIC TRIAL
PHASE3 Auburn, Alabama +4 sites NCT04692493
This trial is looking for people with active rheumatoid arthritis who have not improved with their current treatment. Participants will have the chance to switch to a different type of medication to see if it helps their condition.
Recruiting
Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans
PHASE3 Birmingham, Alabama +4 sites NCT06488144
This trial is looking for veterans with knee osteoarthritis who are starting physical therapy. Participants will receive support and encouragement to maintain their exercise routine over two years with follow-up visits.
Recruiting
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
PHASE2 Birmingham, Alabama +4 sites NCT07641517
This trial is looking for people with knee pain from osteoarthritis to test a new treatment. Participants will need to meet specific health criteria to join the study.
Recruiting
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
PHASE2 Birmingham, Alabama +4 sites NCT06884865
This trial is looking for people aged 45 to 80 who have been dealing with knee pain from osteoarthritis for at least a year and have tried other treatments that didn’t work. They’re also looking for individuals who don’t have certain autoimmune diseases or infections and haven't had specific knee treatments in the last six months.
Recruiting
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
PHASE1 Birmingham, Alabama +4 sites NCT07201558
This trial is looking for adults with rheumatoid arthritis or systemic lupus erythematosus. Participants will receive an injection of a study drug called surovatamig and will be monitored for how safe and effective it is.
Recruiting
A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
PHASE1 Anniston, Alabama +4 sites NCT07258849
This trial is looking for healthy adults and adults with rheumatoid arthritis. Participants will take a study drug and have their blood tested to see how their body responds to it over about 33 weeks.
Recruiting
ConsideRAte Study - Splenic Stimulation for RA
NA Anniston, Alabama +4 sites NCT05003310
This trial is looking for people with rheumatoid arthritis that hasn’t improved with other treatments. Participants will receive stimulation therapy using a special device to see if it helps their condition.
Recruiting
Developing an Opioid Taper Intervention Before Total Joint Arthroplasty
NA Birmingham, Alabama NCT05788016
This trial is looking for patients who are scheduled for knee or hip replacement surgery and currently take opioids for pain. Participants will meet with a pharmacist to get help reducing their opioid dose before surgery.
Recruiting
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
PHASE2 Birmingham, Alabama +4 sites NCT05986292
This trial is looking for people with chronic pain from conditions like osteoarthritis or diabetic neuropathic pain. Participants will undergo treatments while being monitored for their pain levels.
Recruiting
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
PHASE2 Tuscaloosa, Alabama +4 sites NCT06991114
This trial is looking for adults with certain autoimmune diseases, like rheumatoid arthritis or systemic sclerosis, who haven't responded well to standard treatments. It's important that they've had these conditions diagnosed recently and have tried other medicines without success. People with other serious health issues or who are pregnant may not be able to participate.
Recruiting
Diet Interventions: Remitted and Evaluated as Complementary Treatments for Pain
NA Birmingham, Alabama NCT05785884
Recruiting
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
PHASE1 Anniston, Alabama +4 sites NCT06916806
This trial is looking for adults with Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, or Rheumatoid Arthritis. Participants will receive the study drug AZD5492 either once or twice during the trial period and will attend several check-up visits over at least 180 days.
Recruiting
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
PHASE1 Anniston, Alabama +4 sites NCT07607964
This trial is looking for adults with systemic lupus erythematosus or rheumatoid arthritis. Participants will receive treatment and attend regular check-ups to assess the effects and safety of the drug.
Recruiting
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
PHASE3 Birmingham, Alabama +4 sites NCT07339111
This trial is looking for adults with knee cartilage defects and osteoarthritis. Participants will receive either CARTISTEM®, a stem cell treatment, or a surgical procedure to improve knee function and reduce pain.
Recruiting
Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare
PHASE2 Birmingham, Alabama +4 sites NCT05658575
This trial is looking for adults with an acute gout flare. Participants will take dapansutrile tablets and help researchers learn about its effects on gout symptoms.
Recruiting
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
N/A Birmingham, Alabama +4 sites NCT02418442
This trial is looking for children and teenagers with rheumatic joint diseases. If you join, you will help researchers gather important information about treatments used for these conditions.
Recruiting
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
PHASE1 Birmingham, Alabama +4 sites NCT03816345
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
Recruiting
See all 19 Arthritis trials in Alabama

Where the Arthritis studies are in Alabama

Research sites running the most studies
  • University of Alabama at Birmingham, Birmingham4 trials
  • Central Research Associates, Birmingham2 trials
  • Pinnacle Research Group, LLC, Anniston2 trials
  • Research Site, Birmingham2 trials
  • AMR Clinical, Mobile1 trial
  • Alabama Clinical Therapeutics, LLC, Birmingham1 trial
By city

Counts are recruiting studies listing at least one site in Alabama, from ClinicalTrials.gov, refreshed every two days.

Arthritis clinical trials in Alabama: common questions

How many Arthritis clinical trials are recruiting in Alabama?
TrialFinder currently lists 19 recruiting Arthritis clinical trials with study sites in Alabama. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Arthritis clinical trials located in Alabama?
Study sites for the Arthritis trials listed on this page include Birmingham, Mobile, Auburn, Anniston, Tuscaloosa. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Arthritis clinical trial in Alabama?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Arthritis trials in Alabama also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Arthritis clinical trial in Alabama?
Each study sets its own criteria based on age, Arthritis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Which type of arthritis do trials enroll?
Each listing names one: rheumatoid, osteoarthritis (most often knee), psoriatic, ankylosing spondylitis or gout. Rheumatoid and knee osteoarthritis have the most recruiting trials.
Do I need to stop my arthritis medicine to join a trial?
For rheumatoid arthritis, methotrexate usually continues and a biologic is stopped after a supervised washout. Osteoarthritis trials ask that you have had no joint injection for a few months and may limit daily pain medicine.
Are there arthritis trials that do not involve medicine?
Yes. Exercise, physical therapy, weight management, braces and devices, and diet studies all recruit, mostly for knee and hip osteoarthritis.
Arthritis Trials in Other States
Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Arthritis Trials

Arthritis trials test biologics, JAK inhibitors, stem-cell therapies, and pain-management protocols for rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

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