49 Recruiting Trials

Clinical Trials
for Diabetes in Alabama

49 clinical trials for Diabetes are currently recruiting participants at study sites in Alabama. Study-related care is provided at no cost.

49
Recruiting trials
49
Study sites
13
Cities
28
Industry-sponsored
10
Phase 2
20
Phase 3

Diabetes clinical trials in Alabama: what to expect

Diabetes is one of the largest areas of clinical research, and the trials differ a great deal by type. Type 2 studies most often test new glucose-lowering or weight-reducing medicines, once-weekly insulins, and combinations with GLP-1 drugs, in people whose A1c is above goal on their current treatment. Type 1 studies test automated insulin delivery systems, immune therapies for people recently diagnosed or at high risk, and cell-based approaches. Others focus on the complications: kidney disease, eye disease, nerve pain and foot ulcers.

In Alabama, recruiting diabetes studies are concentrated in Birmingham, Huntsville, Mobile and Anniston, with sites in 9 other cities. 28 of the 49 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who diabetes trials usually look for

Type 2 trials typically ask for a confirmed diagnosis, an A1c in a stated range (often between 7 and 10.5 percent) and a stable dose of your current medicines for at least a few months. Many exclude recent insulin use, a recent heart attack or stroke, or kidney function below a cut-off. Type 1 trials are often limited by time since diagnosis and by age, and some enroll children and teenagers with a parent's consent.

You do not need to know your A1c or kidney numbers to ask about a trial; the site measures them at screening.

What taking part involves

Screening includes blood work and a review of your history. Medicine trials usually last six months to three years with visits every one to three months, and many provide a glucose monitor and supplies for the duration. Some compare a new drug with a standard one rather than a placebo, so everyone receives active treatment; others include a placebo arm, and the consent form says which. Study drugs, devices, visits and labs are provided at no cost, and most trials pay for time and travel.

Questions worth asking the study team

Whether you would stay on your current medicines; whether there is a placebo group; how often visits are and whether any can be done remotely; and whether your own doctor will receive the results of study labs. If you have type 1 diabetes, ask whether the study uses your own pump or monitor.

Showing 20 of 49 recruiting Diabetes trials in Alabama

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662213
This trial is looking for adults with type 2 diabetes who struggle to manage their condition. Participants will compare the effectiveness of a new drug, elecoglipron, with an existing treatment, semaglutide.
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
PHASE3 Birmingham, Alabama +4 sites NCT07754461
This trial is looking for adults with type 2 diabetes who want to try a new medicine called survodutide to help control their blood sugar levels. Participants will receive either the medicine or a placebo and will continue their usual diabetes treatments over about 14 months with regular check-ins.
Recruiting
AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
PHASE3 Birmingham, Alabama +4 sites NCT07533175
This trial is looking for people who have excess weight and type 2 diabetes. Participants will receive either the study medication NNC0487-0111 or a placebo shot once a week, decided by chance.
Recruiting
Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
PHASE3 Cullman, Alabama +4 sites NCT07284901
This trial is looking for people with obesity or overweight who also have type 2 diabetes. Participants will receive a weekly injection of ribupatide to see how it affects their weight and blood sugar levels.
Recruiting
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications
PHASE3 Birmingham, Alabama +4 sites NCT07797335
This trial is looking for adults with type 2 diabetes who are at high risk for heart problems. Participants will receive injections of either zenagamtide or insulin glargine once a week to see which works better for controlling blood sugar and weight.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus
PHASE3 Birmingham, Alabama +4 sites NCT07662044
This trial is looking for adults with type 2 diabetes that is not well controlled. Participants will take elecoglipron alone or with another medication and compare the effects to a placebo.
Recruiting
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
PHASE3 Huntsville, Alabama +4 sites NCT07662109
This trial is looking for adults with Type 2 Diabetes who have been managing their condition for at least three months but still need better control. They're particularly interested in those whose blood sugar levels are in a specific range and who have a body weight that meets certain guidelines. However, they’re not accepting people with certain serious health issues, like a history of severe low blood sugar or specific types of diabetes other than Type 2.
Recruiting
Denosumab for Type 1 Diabetes
PHASE1 Birmingham, Alabama +2 sites NCT06524960
This trial is looking for people with early type 1 diabetes. Participants will receive treatment with denosumab to see if it helps protect insulin-producing cells and improve blood sugar control.
Recruiting
Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy
PHASE2 Birmingham, Alabama +4 sites NCT07502508
This trial is looking for adults with Type 2 Diabetes who are not reaching their blood sugar goals while using Ozempic. Participants will take icovamenib to see if it helps improve their condition.
Recruiting
A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
PHASE2 Birmingham, Alabama +4 sites NCT07668388
This trial is looking for people with type 2 diabetes to test a new medicine called UBT251. Participants will receive either UBT251, a placebo, or another medication called semaglutide, chosen at random.
Recruiting
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
PHASE2 Birmingham, Alabama +4 sites NCT07340320
This trial is looking for adults with type 2 diabetes who aren't able to control their blood sugar well while taking metformin. Participants will receive either the new medication CX11 or a placebo for 24 weeks, followed by a 2-week follow-up.
Recruiting
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes
PHASE2 Birmingham, Alabama +4 sites NCT05762107
This trial is looking for adults with type 1 diabetes who experience low blood sugar at night. Participants will receive either the study drug ZT-01 or a placebo for two weeks while using a glucose monitor to track their blood sugar levels.
Recruiting
Pharmacokinetic and Early Efficacy of OPT101 in Patients With Type 1 Diabetes Mellitus
PHASE2 Birmingham, Alabama +4 sites NCT06964087
This trial is looking for adults with Type 1 Diabetes who are interested in testing a new treatment called OPT101. Participants will receive injections of the treatment or a placebo and will need to wear a continuous glucose monitor for the study's duration.
Recruiting
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
PHASE4 Tuscaloosa, Alabama +4 sites NCT06445946
This trial is looking for pregnant women who are at least 18 years old and have been diagnosed with gestational diabetes, needing medication to manage their blood sugar. It’s important that they do not have any serious kidney problems or other specific health conditions that could complicate the study. Women are also excluded if they have certain fetal conditions or previous diabetes issues before pregnancy.
Recruiting
PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes
PHASE4 Huntsville, Alabama +4 sites NCT05390892
This trial is looking for people with type 2 diabetes and heart disease or at high risk for heart disease. Participants will take one of two medications and will be monitored for heart, kidney, and death-related events over time.
Recruiting
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
NA Birmingham, Alabama +4 sites NCT05124808
This trial is looking for overweight and obese pregnant women who have been diagnosed with gestational diabetes. Participants will compare different approaches to blood sugar control during pregnancy.
Recruiting
Advancing Diabetes Management for People With Physical Disabilities Optimally Through Primary Care-Based Telehealth (ADDOPT)
NA Birmingham, Alabama NCT07032844
This trial is looking for individuals with physical disabilities and type 2 diabetes. Participants will compare two ways to manage their diabetes using technology to see which is more effective for reducing blood sugar levels and improving health.
Recruiting
Recruiting
CGM for Management of Type 2 Diabetes in Pregnancy
NA Birmingham, Alabama +4 sites NCT06628453
This trial is looking for pregnant women with type 2 diabetes to see if using a continuous glucose monitor is better than checking blood sugar with fingersticks. Participants will monitor their blood sugar, complete surveys, and provide blood samples during the trial.
Recruiting

Where the Diabetes studies are in Alabama

  • University of Alabama at Birmingham, Birmingham11 trials
  • Research Site, Birmingham3 trials
  • Research Site, Huntsville3 trials
  • Birmingham Clinical Research, Birmingham2 trials
  • Kailera Clinical Site, Cullman2 trials
  • Lakeview Clinical Research, Guntersville2 trials

Counts are recruiting studies listing at least one site in Alabama, from ClinicalTrials.gov, refreshed every two days.

Diabetes clinical trials in Alabama: common questions

How many Diabetes clinical trials are recruiting in Alabama?
TrialFinder currently lists 49 recruiting Diabetes clinical trials with study sites in Alabama. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Diabetes clinical trials located in Alabama?
Study sites for the Diabetes trials listed on this page include Birmingham, Anniston, Cullman, Huntsville, Tuscaloosa. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Diabetes clinical trial in Alabama?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Diabetes trials in Alabama also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Diabetes clinical trial in Alabama?
Each study sets its own criteria based on age, Diabetes diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I join a diabetes clinical trial if I am already on medication?
Usually yes. Most type 2 diabetes trials enroll people on metformin or other oral medicines and test a new treatment on top of them; some require a stable dose for a few months first. Trials that exclude insulin or a specific drug say so in their criteria.
Do I need to know my A1c to apply?
No. Trials state an A1c range, but the study site measures it at the screening visit. You only need to know that you have been diagnosed and which type.
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Diabetes clinical trials study new treatments for Type 1, Type 2, and gestational diabetes, including insulin therapies, diet interventions, and islet-cell transplants.

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