COVID-19 Trials / Trials in Alabama
10 Recruiting Trials

Clinical Trials
for COVID-19 in Alabama

10 clinical trials for COVID-19 are currently recruiting participants at study sites in Alabama. Study-related care is provided at no cost.

10
Recruiting trials
9
Study sites
6
Cities
5
Industry-sponsored
1
Phase 2
2
Phase 3

COVID-19 clinical trials in Alabama: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

In Alabama, recruiting covid-19 studies are concentrated in Birmingham, Mobile, Anniston and Cullman, with sites in 2 other cities. 5 of the 10 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 10 of 10 recruiting COVID-19 trials in Alabama

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
NA Birmingham, Alabama +4 sites NCT05218083
This trial is looking for people who have been seriously ill with COVID-19 and are ready to go home from the hospital. Participants will receive support for a physical rehabilitation program that includes exercise sessions monitored through mobile health technology.
Recruiting
Clinical Validation of the Aptitude Medical Systems Metrix COVID-19 Test
NA Birmingham, Alabama +2 sites NCT06744660
This trial is looking for people who are at least 2 years old and have symptoms of a respiratory infection. Participants will provide swab samples for testing in a home-like environment.
Recruiting
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
PHASE3 Cullman, Alabama +4 sites NCT06667700
This trial is looking for adults at high risk for severe illness from COVID-19. Participants will take the study drug molnupiravir or a placebo and monitor their health over time.
Recruiting
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
PHASE3 Huntsville, Alabama +4 sites NCT06679140
This trial is looking for teens aged 12 to 17 who weigh at least 40 kg and adults aged 18 and older, especially those at risk of getting seriously ill from COVID-19. Participants should have recently tested positive for COVID-19 and show some symptoms, but they shouldn’t be in need of hospitalization. People with certain serious health issues or those who are very sick right now won't be able to join.
Recruiting
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
PHASE1 Anniston, Alabama +4 sites NCT07464314
This trial is looking for healthy adults aged 65 to 85 years who want to help test a new vaccine that combines protection against the flu and COVID-19. Participants will receive different doses of the vaccine or standard vaccines and will be monitored for side effects and immune response.
Recruiting
Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure
PHASE2 Mobile, Alabama NCT04445285
This trial is looking for adults with COVID-19 who are having serious trouble breathing. Participants will receive a treatment to see if it can help reduce deaths over 28 days.
Recruiting
Testimonials and Navigation in Rheumatology
NA Birmingham, Alabama +2 sites NCT06469788
This trial is looking for adults with autoimmune diseases who identify as Black or Latinx and have not received the updated COVID-19 vaccine. Participants will engage in a support program at rheumatology clinics to help them get vaccinated.
Recruiting
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
N/A Birmingham, Alabama +4 sites NCT03452774
This trial is looking for cancer patients to see if an AI tool can help match them to clinical trials. Patients will have their cancer-related biomarkers evaluated to find suitable studies for their condition.
Recruiting
ME/CFS Brain Fog: Cognitive Rehabilitation Trial
NA Birmingham, Alabama NCT07523113
This trial is looking for adults with cognitive impairment and brain fog resulting from past viral infections like COVID-19 or EBV. Participants will take part in online training to help improve their cognitive abilities, with some visits required for tests and procedures.
Recruiting
Long COVID Brain Fog: Cognitive Rehabilitation Trial
NA Birmingham, Alabama NCT06095297
This trial is looking for adults with long COVID who have ongoing issues with thinking and memory. Participants will try different brain training methods to improve their cognitive skills and daily functioning.
Recruiting
See all 10 COVID-19 trials in Alabama

Where the COVID-19 studies are in Alabama

Research sites running the most studies
  • University of Alabama at Birmingham, Birmingham4 trials
  • AFC Madison, Madison1 trial
  • AFC Montclair, Birmingham1 trial
  • Cullman Clinical Trials ( Site 3813), Cullman1 trial
  • GSK Investigational Site, Anniston1 trial
  • Massive Bio SYNERGY-AI site, Birmingham1 trial
By city

Counts are recruiting studies listing at least one site in Alabama, from ClinicalTrials.gov, refreshed every two days.

COVID-19 clinical trials in Alabama: common questions

How many COVID-19 clinical trials are recruiting in Alabama?
TrialFinder currently lists 10 recruiting COVID-19 clinical trials with study sites in Alabama. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in Alabama?
Study sites for the COVID-19 trials listed on this page include Birmingham, Cullman, Huntsville, Anniston, Mobile. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COVID-19 clinical trial in Alabama?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in Alabama also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in Alabama?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COVID-19 Trials

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

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