135 Recruiting Trials

Clinical Trials
for COVID-19

COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.

COVID-19 clinical trials: what to expect

COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.

Who COVID-19 trials usually look for

Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.

What taking part involves

Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.

Questions worth asking the study team

How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.

Showing 15 of 135 recruiting trials

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
PHASE3 Cullman, Alabama +4 more NCT06667700
Recruiting
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
PHASE3 Huntsville, Alabama +4 more NCT06679140
Recruiting
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
PHASE3 Canoga Park, California +4 more NCT07013474
Recruiting
Safety and Serum Virus Neutralizing Antibody Responses of VYD2311, a COVID-19 Vaccine, and Coadministered VYD2311 With a COVID-19 Vaccine
PHASE3 Overland Park, Kansas NCT07655180
Recruiting
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
PHASE3 Phoenix, Arizona +4 more NCT05261139
Recruiting
Arginine Replacement Therapy in COVID-19
PHASE2 Atlanta, Georgia NCT05855330
Recruiting
Convalescent Plasma as a Possible Treatment for COVID-19
PHASE2 Chicago, Illinois NCT04442191
Recruiting
Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19
PHASE4 Fair Oaks, California +4 more NCT07861542
Recruiting
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
PHASE1 Anniston, Alabama +4 more NCT07464314
Recruiting
Home-Based Exercise Tele-Rehabilitation After COVID-19
NA Baltimore, Maryland NCT05425264
Recruiting
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
NA Birmingham, Alabama +4 more NCT05218083
Recruiting
Care for Veterans Post-COVID-19
NA East Orange, New Jersey NCT05787379
Recruiting
Connecting Friends and Health Workers to Boost COVID-19 Vaccination in Latino Communities
NA Baltimore, Maryland NCT06128928
Recruiting
Clinical Validation of the Aptitude Medical Systems Metrix COVID-19 Test
NA Birmingham, Alabama +2 more NCT06744660
Recruiting
Vale+Tú Salud: Corner-Based Trial to Test a Latino Day Laborer Program Adapted to Prevent COVID-19
NA Houston, Texas NCT06821113
Recruiting
See all 135 results

COVID-19 clinical trials by state

Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming

Questions about COVID-19 clinical trials

How many clinical trials are available for COVID-19?
TrialFinder currently lists 135 recruiting clinical trials for COVID-19. Listings are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Are COVID-19 clinical trials free to participate in?
Study-related care is provided at no cost to participants. The sponsor covers the study treatment, required lab tests, imaging and study visits, and many trials also pay for time and travel. You do not need health insurance to enroll.
How do I qualify for a COVID-19 clinical trial?
Each trial sets its own criteria based on age, diagnosis, prior treatment, current medications and general health. The fastest way to find out is to contact the study site: most will pre-screen you by phone in 10 to 15 minutes at no charge.
How do I find COVID-19 clinical trials near me?
Pick your state below to see recruiting COVID-19 trials there with their sites and cities, or search by city or zip code. Results show actively recruiting trials sorted by distance.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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