27 Recruiting Trials
Clinical Trials
for COVID-19 in Maryland
27 clinical trials for COVID-19 are currently recruiting participants at study sites in Maryland. Study-related care is provided at no cost.
27
Recruiting trials
26
Study sites
8
Cities
9
Industry-sponsored
2
Phase 2
6
Phase 3
COVID-19 clinical trials in Maryland: what to expect
COVID-19 research has shifted from the acute illness to its aftermath and its prevention. The most active area is long COVID: trials of antivirals, immune treatments and rehabilitation for fatigue, brain fog, breathlessness and rapid-heartbeat symptoms that persist months after infection. Vaccine trials test updated and next-generation vaccines, including nasal and combined flu-and-COVID shots. Treatment trials for people at high risk, and prevention studies for people with weakened immune systems, continue as well.
In Maryland, recruiting covid-19 studies are concentrated in Baltimore, Bethesda, Silver Spring and Rockville, with sites in 4 other cities. 9 of the 27 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who COVID-19 trials usually look for
Long COVID trials ask for symptoms that began after a confirmed or strongly suspected infection and have lasted at least three months, often with a particular symptom named. Acute treatment trials need a positive test within the past few days plus a risk factor such as age or a chronic condition. Vaccine trials specify an age group and your vaccination history, and most want people who are generally healthy. Many trials exclude pregnancy and a recent infection or vaccination.
What taking part involves
Long COVID trials run twelve to twenty-four weeks with questionnaires, sometimes exercise or breathing tests, and visits that can often be done by phone or video; many are placebo controlled. Vaccine trials involve one or two injections, a symptom diary for a week after each, a few blood draws and follow-up calls for a year or more. Acute treatment trials start the day you enroll, with swabs and check-ins for a few weeks. Study treatment and tests are free and visits are usually paid.
Questions worth asking the study team
How many visits must be in person; the chance of placebo; whether you can continue your current treatments; what counts as documentation of your original infection; and whether you will learn your own test results.
Showing 20 of 27 recruiting COVID-19 trials in Maryland
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
Recruiting
This trial is looking for adults at high risk for severe illness from COVID-19. Participants will take the study drug molnupiravir or a placebo and monitor their health over time.
A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
Recruiting
This trial is looking for teens aged 12 to 17 who weigh at least 40 kg and adults aged 18 and older, especially those at risk of getting seriously ill from COVID-19. Participants should have recently tested positive for COVID-19 and show some symptoms, but they shouldn’t be in need of hospitalization. People with certain serious health issues or those who are very sick right now won't be able to join.
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
Recruiting
This trial is looking for adults who are severely immunocompromised and have COVID-19. Participants will receive either ibuzatrelvir alone or with another medication to see how well it works against the virus.
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
Recruiting
This trial is looking for young patients under 18 years old who have COVID-19 but are not hospitalized, and may be at risk for more severe illness. Participants will be given a medicine called nirmatrelvir/ritonavir to help treat their condition.
Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19
Recruiting
This trial is looking for older adults and younger individuals with health conditions that increase their risk of severe COVID-19. Participants will receive a single injection and have follow-up calls over three months.
Connecting Friends and Health Workers to Boost COVID-19 Vaccination in Latino Communities
Recruiting
This trial is looking for Latino adults in Maryland who have been vaccinated against COVID-19 to help encourage their friends to get vaccinated. Participants will either learn how to motivate their friends or receive standard information about the vaccine.
Home-Based Exercise Tele-Rehabilitation After COVID-19
Recruiting
This trial is looking for Veterans who have recovered from COVID-19 and have certain health conditions. Participants will engage in a supervised exercise program at home to improve their health and physical abilities.
Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
Recruiting
This trial is looking for people of all ages who have been infected with or exposed to COVID-19 or respiratory viruses. Participants will send in samples like blood and possibly stool for analysis without needing to visit the study site.
The Impact of COVID-19 on Maternal and Neonatal Outcomes
Recruiting
This trial is looking for pregnant women who get their prenatal care at specific hospitals, as well as those who are delivering their babies there. Participants will help researchers learn more about the effects of COVID-19 on pregnancy and newborns.
Covid-19 Long Haul Preventative and Health Promotion Care Clinical Trial Acceleration Program.
Recruiting
This trial is looking for adults who have had COVID-19 and continue to experience symptoms after recovering from the initial illness. Participants will help researchers understand long-term effects of COVID-19 and explore new treatment possibilities.
Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
Recruiting
This trial is looking for adults aged 50 or older who have long-term symptoms from COVID-19. Participants will either receive a personalized diet plan or attend general health sessions to see how diet impacts their health over 16 weeks.
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
Recruiting
This trial is looking for healthy adults aged 18-64 who have already been vaccinated against COVID-19. Participants will receive a single dose of the OCU500 vaccine through either the nose or inhaled method.
Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection
Recruiting
This trial is looking for people who have recovered from COVID-19 and have either lingering neurological symptoms or no symptoms at all. Participants will provide samples and undergo several health evaluations over four months.
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Recruiting
This trial is looking for children and young adults who are 21 years old or younger and are currently taking certain medications, or who have had a recent COVID-19 infection. They cannot be pregnant or have had certain recent medical procedures like dialysis, organ transplants, or other serious treatments. If you think your child might fit this description, it could be worth considering.
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Recruiting
This trial is looking for immunocompromised patients who have a lower respiratory tract infection due to parainfluenza. Participants will receive treatment with DAS181 and need to meet specific health criteria.
Medical Herbs Inhibit Inflammation Directing T Cells to Kill the COVID-19 Virus (COVID)
Recruiting
This trial is looking for people who have COVID-19 and want to try a treatment with medical herbs. Participants will have to provide some test results and undergo evaluations during the study.
T Cell Therapy Opposing Novel COVID-19 Infection in Immunocompromised Patients
Recruiting
This trial is looking for patients who have recently had a stem cell transplant and are at risk for COVID-19. Participants will receive a special treatment to help prevent infection.
Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
Recruiting
This trial is looking for U.S. Veterans who are obese and have experienced COVID-19 symptoms for at least 4 weeks. Participants will follow a weight loss program that includes diet changes and exercise to see if it helps improve their health and recovery.
Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
Recruiting
This trial is looking for patients in the hospital with pneumonia who need extra oxygen. If you join, you will receive either the AV-001 Injection or a placebo each day until you leave the hospital or for up to 28 days.
COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study
Recruiting
This trial is looking for people to help understand how the COVID-19 pandemic affects alcohol use and related problems. Participants will answer surveys about their alcohol use, stress, and health over a two-year period.
Where the COVID-19 studies are in Maryland
Research sites running the most studies
- National Institutes of Health Clinical Center, Bethesda6 trials
- Johns Hopkins Hospital, Baltimore3 trials
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore2 trials
- Jadestone Clinical Research, Silver Spring2 trials
- All Natural Medicine Clinic, LLC, Rockville1 trial
- Annapolis Internal Medicine - CCT Research ( Site 3700), Annapolis1 trial
By city
Counts are recruiting studies listing at least one site in Maryland, from ClinicalTrials.gov, refreshed every two days.
COVID-19 clinical trials in Maryland: common questions
How many COVID-19 clinical trials are recruiting in Maryland?
TrialFinder currently lists 27 recruiting COVID-19 clinical trials with study sites in Maryland. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COVID-19 clinical trials located in Maryland?
Study sites for the COVID-19 trials listed on this page include Baltimore, Rockville, Bethesda, Hyattsville. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COVID-19 clinical trial in Maryland?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COVID-19 trials in Maryland also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COVID-19 clinical trial in Maryland?
Each study sets its own criteria based on age, COVID-19 diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Are there clinical trials for long COVID?
Yes, and they are among the most active COVID trials. Most require symptoms that have lasted three months or more after an infection and name the symptom they study, such as fatigue, brain fog or breathlessness.
Can I join a COVID vaccine trial if I am already vaccinated?
Usually yes. Most current vaccine trials test updated or next-generation vaccines in people who have been vaccinated before, and ask about the date of your last dose.
Do I need a positive test to join a COVID treatment trial?
For acute treatment, yes, within the last few days. Long COVID trials accept a past positive test or a documented clinical diagnosis, and some accept a strongly suspected infection.
COVID-19 Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
Check Your Eligibility
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About COVID-19 Trials
COVID-19 trials study antiviral agents, monoclonal antibodies, long-COVID interventions, and vaccine platforms for prevention and treatment of SARS-CoV-2 infection.
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