21 Recruiting Trials
Clinical Trials
for Multiple Sclerosis in Maryland
21 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in Maryland. Study-related care is provided at no cost.
21
Recruiting trials
18
Study sites
8
Cities
8
Industry-sponsored
5
Phase 2
4
Phase 3
Multiple Sclerosis clinical trials in Maryland: what to expect
Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.
In Maryland, recruiting multiple sclerosis studies are concentrated in Bethesda, Baltimore, Frederick and Glen Burnie, with sites in 4 other cities. 8 of the 21 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who multiple sclerosis trials usually look for
Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.
What taking part involves
Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.
Questions worth asking the study team
What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.
Showing 20 of 21 recruiting Multiple Sclerosis trials in Maryland
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Recruiting
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Recruiting
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
Recruiting
This trial is looking for adults with progressive multiple sclerosis who are already taking a treatment. Participants will take one of four study drugs and will be monitored for up to 18 months.
Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques
Recruiting
This trial is looking for adults with multiple sclerosis who have specific changes in their brain scans. Participants will be randomly assigned to receive high-dose corticosteroids for three days or no treatment, with follow-up visits to monitor their health.
Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis
Recruiting
This trial is looking for adults with Multiple Sclerosis who are stable on treatment. Participants will take either the study drug or a placebo to help see if it can reduce brain and eye damage.
Solriamfetol for the Treatment of Multiple Sclerosis Fatigue
Recruiting
This trial is looking for adults aged 18 to 60 who have multiple sclerosis and experience significant fatigue. Participants will try a medication or placebo for a short time and share their experiences with fatigue using an app.
Study of Ublituximab for Ocrelizumab Wearing-Off in Multiple Sclerosis
Recruiting
This trial is looking for people with multiple sclerosis who are experiencing worsening symptoms while on ocrelizumab treatment. Participants will have the option to switch from ocrelizumab to ublituximab to see if their symptoms improve.
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Recruiting
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Recruiting
This trial is looking for people with multiple sclerosis (MS) or healthy volunteers. Participants will undergo MRI scans and provide samples to help understand the disease.
Pathological Basis of MRI Signal Changes in Multiple Sclerosis
Recruiting
This trial is looking for adults with multiple sclerosis or a similar brain condition. Participants will undergo various tests including MRIs and eye exams, and will be followed for their health over time.
Genes and Environment in Multiple Sclerosis
Recruiting
This trial is looking for people who might be at risk for multiple sclerosis due to genetics or other factors. Participants will help researchers understand these risks better, which could lead to ways to prevent or treat the disease.
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Recruiting
This trial is looking for people with relapsing multiple sclerosis who have been treated with ocrelizumab and want to switch to remibrutinib. Participants will take remibrutinib and their health will be monitored.
The SetPoint System as a Pro-Remyelination Therapy for Relapsing-Remitting Multiple Sclerosis: A Pilot Study
Recruiting
This trial is looking for adults with relapsing-remitting multiple sclerosis (RRMS) to test a new device. Participants will have a small device placed under their skin in a procedure to see if it helps with their condition.
Exploration of Novel Imaging Biomarkers on OCT for Ublituximab Treatment Response in Multiple Sclerosis
Recruiting
This trial is looking for patients with relapsing multiple sclerosis who are starting or have recently been advised to start ublituximab treatment. Participation involves having specialized eye scans during the study to track how the treatment affects immune cell activity in the eyes.
A Study on the Safety of Ozanimod Exposure in Pregnant Women and Their Offspring
Recruiting
This trial is looking for pregnant women diagnosed with multiple sclerosis. It aims to gather information on the effects of a medication called ozanimod during pregnancy and how it affects mothers and their babies.
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
Recruiting
This trial is looking for people with relapsing multiple sclerosis. Participants will receive a modified treatment of ublituximab and help researchers understand its effectiveness and safety.
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy
Recruiting
This trial is looking for adults with Multiple Sclerosis, Progressive Multifocal Leukoencephalopathy, or other neuroinflammatory diseases. Participants will attend the clinic for several visits and undergo tests including imaging and possibly a spinal tap.
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
Recruiting
This trial is looking for people who have been diagnosed with Adjustment Disorder due to cancer or certain other health conditions. Participants will receive a single dose of the study drug to see if it helps reduce their depressive or anxiety symptoms.
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Recruiting
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
Recruiting
This trial is looking for people aged 12 and older who have symptoms of immune issues affecting the brain or spinal cord, as well as healthy volunteers for comparison. Participants will have tests including MRIs and neurological exams to help researchers learn more about these conditions.
Where the Multiple Sclerosis studies are in Maryland
Research sites running the most studies
- National Institutes of Health Clinical Center, Bethesda8 trials
- Johns Hopkins University, Baltimore3 trials
- Baltimore Veterans Affairs Medical Center- Site Number : 8400163, Baltimore1 trial
- Clinre Comprehensive Neurology, Frederick1 trial
- Evidera, Bethesda1 trial
- Evidera INC., Bethesda1 trial
By city
Counts are recruiting studies listing at least one site in Maryland, from ClinicalTrials.gov, refreshed every two days.
Multiple Sclerosis clinical trials in Maryland: common questions
How many Multiple Sclerosis clinical trials are recruiting in Maryland?
TrialFinder currently lists 21 recruiting Multiple Sclerosis clinical trials with study sites in Maryland. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in Maryland?
Study sites for the Multiple Sclerosis trials listed on this page include Bethesda, Baltimore. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in Maryland?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in Maryland also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in Maryland?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
Multiple Sclerosis Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Multiple Sclerosis Trials
MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.
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