Multiple Sclerosis Trials / Trials in North Carolina
14 Recruiting Trials

Clinical Trials
for Multiple Sclerosis in North Carolina

14 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.

14
Recruiting trials
16
Study sites
6
Cities
12
Industry-sponsored
3
Phase 2
6
Phase 3

Multiple Sclerosis clinical trials in North Carolina: what to expect

Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.

In North Carolina, recruiting multiple sclerosis studies are concentrated in Raleigh, Charlotte, Durham and Wilmington, with sites in 2 other cities. 12 of the 14 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who multiple sclerosis trials usually look for

Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.

What taking part involves

Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.

Questions worth asking the study team

What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.

Showing 14 of 14 recruiting Multiple Sclerosis trials in North Carolina

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
PHASE3 Birmingham, Alabama +4 sites NCT07225504
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Recruiting
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
PHASE3 Cullman, Alabama +4 sites NCT07325292
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Recruiting
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
PHASE1 La Jolla, California +4 sites NCT07477639
This trial is looking for adults with two types of Multiple Sclerosis called primary progressive or secondary progressive MS. Participants will receive a treatment called TRX319 and will undergo tests to check the treatment's safety and effectiveness over about a year.
Recruiting
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
N/A Birmingham, Alabama +4 sites NCT06433752
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Recruiting
A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
N/A Wilmington, North Carolina NCT06433765
This trial is looking for pregnant women with Multiple Sclerosis to compare birth outcomes between those who took BRIUMVI® and those who did not. Participants must have been pregnant recently or are currently pregnant.
Recruiting
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
PHASE3 Palo Alto, California +4 sites NCT04047628
This trial is looking for adults with treatment-resistant multiple sclerosis. Participants will be randomly assigned to receive either stem cell transplantation or the best available therapy and will be followed for 6 years.
Recruiting
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
PHASE3 Scottsdale, Arizona +4 sites NCT06846281
This trial is looking for people with relapsing multiple sclerosis who have been treated with ocrelizumab and want to switch to remibrutinib. Participants will take remibrutinib and their health will be monitored.
Recruiting
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
PHASE3 Pheonix, Arizona +4 sites NCT07067463
This trial is looking for people with Primary Progressive Multiple Sclerosis (PPMS). Participants will take either the study drug orelabrutinib or a placebo for about 30 to 60 months, with at least 12 months of treatment.
Recruiting
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
PHASE2 Raleigh, North Carolina +2 sites NCT07840326
This trial is looking for men and women aged 18-70 with non-active secondary progressive or primary progressive multiple sclerosis. Participants will take part in studying the safety of a medication called SUN-627 and will need to meet certain health criteria.
Recruiting
A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk
N/A Wilmington, North Carolina +4 sites NCT06143514
This trial is looking for breastfeeding women who are being treated with BRIUMVI™ for relapsing multiple sclerosis. Participants will provide breast milk for testing during the study.
Recruiting
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
N/A Durham, North Carolina +4 sites NCT05658497
This trial is looking for women with multiple sclerosis who are pregnant or planning to become pregnant. Participants will share information about their use of Vumerity and other treatments during their pregnancy.
Recruiting
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
PHASE3 Birmingham, Alabama +4 sites NCT05877963
This trial is looking for people with relapsing multiple sclerosis. Participants will receive a modified treatment of ublituximab and help researchers understand its effectiveness and safety.
Recruiting
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
PHASE2 Birmingham, Alabama +4 sites NCT07002034
This trial is looking for people who have been diagnosed with Adjustment Disorder due to cancer or certain other health conditions. Participants will receive a single dose of the study drug to see if it helps reduce their depressive or anxiety symptoms.
Recruiting
Retinal Imaging in Neurodegenerative Disease
N/A Durham, North Carolina NCT03233646
This trial is looking for adults with neurodegenerative diseases or no neurodegenerative disease. Participants will undergo imaging tests to assess their eye health.
Recruiting
See all 14 Multiple Sclerosis trials in North Carolina

Where the Multiple Sclerosis studies are in North Carolina

Research sites running the most studies
  • Duke University Medical Center, Durham2 trials
  • TG Therapeutics Investigational Trial Site, Raleigh2 trials
  • Velocity Clinical Research, Raleigh2 trials
  • Atrium Health, Charlotte1 trial
  • BRIUMVI® Pregnancy Registry Virtual Research Coordination Center, Wilmington1 trial
  • Duke University, Durham1 trial
By city

Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.

Multiple Sclerosis clinical trials in North Carolina: common questions

How many Multiple Sclerosis clinical trials are recruiting in North Carolina?
TrialFinder currently lists 14 recruiting Multiple Sclerosis clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in North Carolina?
Study sites for the Multiple Sclerosis trials listed on this page include Wilmington, Raleigh, Durham. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in North Carolina?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
Multiple Sclerosis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Multiple Sclerosis Trials

MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.

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