21 Recruiting Trials
Clinical Trials
for Asthma in North Carolina
21 clinical trials for Asthma are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.
21
Recruiting trials
33
Study sites
14
Cities
12
Industry-sponsored
5
Phase 2
6
Phase 3
Asthma clinical trials in North Carolina: what to expect
Most recruiting asthma trials are for moderate-to-severe asthma that stays uncontrolled on an inhaled steroid. They test biologic injections aimed at the type of inflammation driving your asthma, new inhaler combinations, and longer-acting versions of existing drugs. Others study asthma in children, exercise and self-management programs, and ways to reduce flare-ups that lead to urgent care visits.
In North Carolina, recruiting asthma studies are concentrated in Durham, Chapel Hill, Charlotte and Asheville, with sites in 10 other cities. 12 of the 21 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who asthma trials usually look for
Trials ask for a confirmed diagnosis, a daily maintenance inhaler at a stated dose, and usually one or two flare-ups in the past year that needed oral steroids. Breathing tests at screening must fall in a range, and biologic trials pick participants by a blood eosinophil count or allergy markers measured at the site. Most adult trials exclude current smokers and people with COPD or another lung disease. Separate studies enroll children aged 6 to 11 and teenagers.
What taking part involves
Screening includes spirometry and blood work, then a run-in of a few weeks while you record symptoms and inhaler use in a diary or app. Biologic trials give an injection every two to eight weeks for six to twelve months, with breathing tests at each visit; many are placebo controlled, with your regular inhalers continued throughout and rescue inhaler always allowed. Flare-ups during the study are treated as usual. Study treatment and tests are free and visits are usually paid.
Questions worth asking the study team
Whether your current inhalers stay the same or are switched to a study inhaler; how often breathing tests are needed; the chance of placebo and whether an extension follows; and what to do during a flare-up while enrolled.
Showing 20 of 21 recruiting Asthma trials in North Carolina
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
Recruiting
This trial is looking for children aged 5 to under 12 with severe asthma. Participants will receive either the treatment or a placebo for their asthma management.
Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma
Recruiting
This trial is looking for adolescents aged 12 to 17 with asthma. Participants will compare two treatments for asthma that are used when needed to see which is more effective and safe.
A Study to Learn About the Study Medicine Called Tilrekimig in People With Severe Asthma
Recruiting
This trial is looking for people with severe asthma who have had multiple asthma attacks in the past year. Participants will receive either the study medicine tilrekimig or a placebo to see if it helps improve their condition.
A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma
Recruiting
This trial is looking for people aged 12 and older who have been diagnosed with asthma for at least six months and currently use a quick-relief inhaler. However, it cannot include anyone who has had serious asthma attacks, recent respiratory infections, or other serious lung problems. If you're a current smoker or have recently smoked, you wouldn't be able to participate either.
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
Recruiting
This trial is looking for adults with moderate-to-severe asthma that is not well controlled. Participants will receive shots of either the study medicine PF-07275315 or a placebo for 12 weeks and attend clinic visits over about 7.5 months.
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
Recruiting
This trial is looking for adults with uncontrolled asthma who are already using medium to high doses of inhaled steroids. Participants will receive injections of a medication called tozorakimab to see how well it works and whether it is safe.
Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes
Recruiting
This trial is looking for adults with overweight who have asthma that started after childhood. Participants will take L-citrulline to see if it improves their asthma control and lung function.
Individualizing Treatment for Asthma in Primary Care (Full Study)
Recruiting
This trial is looking for people with asthma who want to try different treatments to help with their condition. Participants will compare using inhaled corticosteroids or azithromycin to see which is more effective.
NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)
Recruiting
This trial is looking for adults aged 18 to 60 who have moderate to severe asthma. Participants will provide health information and samples, and attend regular check-ups and tests over five years to help researchers understand asthma better.
A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice
Recruiting
This trial is looking for people with asthma to understand their condition better. Participants will share details about their asthma severity, treatments, and health-related quality of life.
Use of fenoTRACK Device for Monitoring Changes of Fractional Exhaled Nitric Oxide (FeNO) in Uncontrolled Asthma Subjects and Controlled Asthma Subjects
Recruiting
This trial is looking for people with asthma to help measure breathing changes using a device called fenoTRACK. Participants will either have uncontrolled asthma or controlled asthma and will be asked to take part in procedures over a few visits.
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)
Recruiting
This trial is looking for adults and teenagers with severe asthma that isn't controlled well by their current treatments. Participants will receive either the study drug GB-0895 or a placebo every six months for a year, with regular check-ins.
A Study of KT-621 Administered Orally to Adult Participants With Moderate to Severe Eosinophilic Asthma
Recruiting
This trial is looking for adults aged 18 to 75 who have moderate to severe eosinophilic asthma that is not well controlled. Participants will take a medication called KT-621 to see how well it works and monitor any side effects.
A Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma
Recruiting
This trial is looking for people with severe asthma who are not managing their symptoms with current treatments. Participants will take Frevecitinib for 12 weeks and will need to provide consent and follow specific guidelines throughout the study.
Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
Recruiting
This trial is looking for children aged 6 to 17 who have moderate to severe asthma. Participants will undergo 8 weeks of inspiratory training to help improve their breathing.
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
Recruiting
This trial is looking for people who have completed a previous study with benralizumab and may benefit from continued treatment. Participants will receive benralizumab and be monitored for safety and how well it works over time.
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Recruiting
This trial is looking for healthy adults aged 18 to 45 to help researchers study how the body responds to environmental factors. Taking part involves a single visit where you'll answer some questions and provide a blood sample.
Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma
Recruiting
This trial is looking for children aged 8 to 17 with obesity and asthma. Participants will use inspiratory muscle rehabilitation to help with breathing and get more active over 8 weeks.
Personalized Environment and Genes Study
Recruiting
This trial is looking for adults with asthma, diabetes, or heart disease to study how our environment and genes affect health. Participants will need to visit a clinical research unit for enrollment and follow-up appointments.
Where the Asthma studies are in North Carolina
Research sites running the most studies
- NIEHS Clinical Research Unit (CRU), Research Triangle Park3 trials
- Duke Healthy Lifestyles Clinic, Durham2 trials
- Research Site, Durham2 trials
- Allergy Partners Clinical Research, Asheville1 trial
- Allergy Partners of Western North Carolina - Site Number: 840131, Asheville1 trial
- American Health Research, Charlotte1 trial
By city
Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.
Asthma clinical trials in North Carolina: common questions
How many Asthma clinical trials are recruiting in North Carolina?
TrialFinder currently lists 21 recruiting Asthma clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Asthma clinical trials located in North Carolina?
Study sites for the Asthma trials listed on this page include Monroe, Durham, Research Triangle Park, Chapel Hill. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Asthma clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Asthma trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Asthma clinical trial in North Carolina?
Each study sets its own criteria based on age, Asthma diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to stop my inhaler to join an asthma trial?
No. Trials add the study treatment to your maintenance inhaler, or replace it with a study-supplied version, and a rescue inhaler is always permitted. Any change is made by the study doctor.
What is an eosinophil count and why do trials ask about it?
It is a type of white blood cell measured in a routine blood test. Many biologic asthma drugs target the inflammation it signals, so trials set a minimum or maximum count. The site measures it at screening.
Are there asthma trials for children?
Yes. Biologics and inhalers approved for adults are studied in children aged 6 to 11 and in teenagers, with a parent consenting and attending visits. The listing states the age range.
Asthma Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Asthma Trials
Asthma trials evaluate biologic therapies, inhaler formulations, allergen immunotherapy, and environmental interventions for moderate-to-severe asthma and COPD overlap.
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