21 Recruiting Trials
Clinical Trials
for COPD in North Carolina
21 clinical trials for COPD are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.
21
Recruiting trials
35
Study sites
20
Cities
15
Industry-sponsored
8
Phase 2
9
Phase 3
COPD clinical trials in North Carolina: what to expect
COPD trials test new inhaler combinations, biologic injections for people whose flare-ups continue despite inhalers, and treatments for the cough and mucus that come with chronic bronchitis. Others study pulmonary rehabilitation and exercise, valves and other procedures for emphysema, home oxygen and remote monitoring, and programs to stop smoking. Most enroll people with moderate to severe disease who still have symptoms on their current treatment.
In North Carolina, recruiting copd studies are concentrated in Winston-Salem, Durham, Charlotte and Fayetteville, with sites in 16 other cities. 15 of the 21 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who COPD trials usually look for
Trials confirm COPD with a breathing test at screening and set a range for lung function, usually between 30 and 80 percent of predicted. Most ask for a smoking history of at least ten pack-years, though current smokers are generally accepted. Biologic trials require one or two flare-ups in the past year needing steroids or antibiotics and sometimes a blood eosinophil count above a threshold. Common exclusions are asthma as the main diagnosis, another significant lung disease and a flare-up in the past four weeks. Ages are usually 40 to 80.
What taking part involves
Screening includes spirometry, blood work and a symptom questionnaire, then a short run-in while you record symptoms. Drug trials run six to twelve months with visits every four to twelve weeks, breathing tests, a six-minute walk in some, and a diary or app. Your maintenance inhalers continue, sometimes replaced by study-supplied versions, and rescue inhaler is always allowed. Rehabilitation trials involve two or three sessions a week for eight to twelve weeks. Study care is free and visits are usually paid.
Questions worth asking the study team
Whether your inhalers stay the same; how breathing tests and walking tests are scheduled; the chance of placebo; what to do during a flare-up while enrolled; and whether oxygen users are accepted.
Showing 20 of 21 recruiting COPD trials in North Carolina
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPD
Recruiting
This trial is looking for adults with chronic obstructive pulmonary disease (COPD) who have been receiving standard medical care. Participants will undergo a one-time procedure to help improve their breathing.
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
Recruiting
This trial is looking for adults aged 40 to 80 who have had COPD for at least a year. Participants will take the study drug Tezepelumab and be monitored for its effects on their condition.
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
Recruiting
This trial is looking for adults with moderate to very severe COPD. Participants will be required to take part in assessments and treatments involving Tezepelumab.
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of Treatment
Recruiting
This trial is looking for people with chronic obstructive pulmonary disease (COPD) who have had recent flare-ups of their condition. Participants will take either the study drug or a placebo every day for a year.
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
Recruiting
This trial is looking for adults with moderate to severe COPD to test a new medication called WIN378. Participants will take the medicine and have their lung function and safety monitored.
Clinical Trial of Omalizumab for Allergen Sensitized and Exposed Individuals With COPD
Recruiting
This trial is looking for individuals with Chronic Obstructive Pulmonary Disease (COPD) and allergies. Participants will take a medication called omalizumab for about a year and have follow-up calls afterwards.
Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia
Recruiting
This trial is looking for adults with chronic obstructive pulmonary disease (COPD) and low oxygen levels. Participants will use an inhaler with Treprostinil four times a day for four weeks and undergo several lung tests to see if the treatment helps improve lung function and oxygen delivery.
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
Recruiting
This trial is looking for patients with chronic obstructive pulmonary disease (COPD) who are not getting symptom relief from their current inhalers. Participants will switch from their inhaler to a nebulizer using similar medications to see if they feel better.
The Study of Chronic Obstructive Pulmonary Disease (COPD) Participants Treated With Dupilumab (STRIDE) Registry
Recruiting
This trial is looking for people with Chronic Obstructive Pulmonary Disease (COPD) who are starting treatment with dupilumab. Participants will share their experiences and health information to help assess the treatment's effectiveness and safety.
SPIROMICS Study of Early COPD Progression (SOURCE)
Recruiting
This trial is looking for people aged 30-55 to study early chronic obstructive pulmonary disease (COPD). Participants will undergo tests like breathing tests and provide samples to help researchers understand who is at risk of developing COPD.
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
Recruiting
This trial is looking for adults aged 40 to 80 with Chronic Obstructive Pulmonary Disease (COPD). Participants will receive a combination inhaler treatment and attend study visits for assessments.
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Recruiting
This trial is looking for people with moderate to very severe COPD to test the effects of a new drug called AZD6793. Participants will take AZD6793 or a placebo and help researchers learn about its safety and effectiveness.
Photon-counting CT in Chest Imaging
Recruiting
This trial is looking for people with COPD who are part of the Duke COPDGene study. Participants will have an additional CT scan using a special machine during their visit.
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
Recruiting
This trial is looking for adults aged 40 to 80 with chronic obstructive pulmonary disease (COPD) that isn't well controlled. Participants will receive either lunsekimig or a placebo for approximately 48 weeks, followed by an 8-week follow-up.
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation
Recruiting
This trial is looking for adults aged 40 to 80 with moderate to severe COPD and type 2 inflammation. Participants will take a new medicine called depemokimab to see how it helps manage their condition.
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
Recruiting
This trial is looking for adults with moderate to severe COPD and type 2 inflammation. Participants will be taking depemokimab as an additional treatment along with their current medications.
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
Recruiting
This trial is looking for adults aged 40 to 80 with chronic obstructive pulmonary disease (COPD) that is not well controlled. Participants will receive either lunsekimig or a placebo for about 48 weeks, followed by an 8-week follow-up.
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Recruiting
This trial is looking for adults aged 35 to 80 with moderate to severe COPD. Participants will receive either the study medicine PF-07275315 or a placebo through shots over 24 to 68 weeks and will attend multiple clinic visits during this time.
eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation
Recruiting
This trial is looking for adults with moderate to severe COPD who have certain inflammation in their lungs, and who are at risk for worsening symptoms. They need to have been diagnosed for at least a year and must not have had any serious lung issues in the past month. It's important that they don't have asthma or other significant lung diseases and aren’t currently using supplemental oxygen.
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
Recruiting
This trial is looking for people with COPD who have had recent respiratory infections. Participants will take a medication called vapendavir to see if it helps reduce their cold symptoms.
Where the COPD studies are in North Carolina
Research sites running the most studies
- Duke University Medical Center, Durham2 trials
- GSK Investigational Site, Winston-Salem2 trials
- Research Site, New Bern2 trials
- Research Site, Wilmington2 trials
- Research Site, Winston-Salem2 trials
- Research Site, Fayetteville2 trials
By city
Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.
COPD clinical trials in North Carolina: common questions
How many COPD clinical trials are recruiting in North Carolina?
TrialFinder currently lists 21 recruiting COPD clinical trials with study sites in North Carolina. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COPD clinical trials located in North Carolina?
Study sites for the COPD trials listed on this page include Salem, Charlotte, Durham, Winston-Salem. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COPD clinical trial in North Carolina?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COPD trials in North Carolina also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COPD clinical trial in North Carolina?
Each study sets its own criteria based on age, COPD diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to quit smoking to join a COPD trial?
Most COPD trials accept current smokers; some require that you have stopped, and smoking-cessation trials are specifically for people who still smoke. The listing states the rule.
What tests confirm COPD for a trial?
Spirometry, a breathing test done at the site before and after a bronchodilator, which gives the lung function figure trials use to set their range. You do not need recent results to ask.
Will I keep using my inhalers during a trial?
Yes. Trials add the study treatment to your maintenance inhalers or supply a standardized equivalent, and a rescue inhaler is always permitted.
COPD Trials in Other States
Alabama
Alaska
Arizona
Arkansas
California
Colorado
Connecticut
Delaware
District of Columbia
Florida
Georgia
Hawaii
Idaho
Illinois
Indiana
Iowa
Kansas
Kentucky
Louisiana
Maine
Maryland
Massachusetts
Michigan
Minnesota
Mississippi
Missouri
Montana
Nebraska
Nevada
New Hampshire
New Jersey
New Mexico
New York
North Dakota
Ohio
Oklahoma
Oregon
Pennsylvania
Rhode Island
South Carolina
South Dakota
Tennessee
Texas
Utah
Vermont
Virginia
Washington
West Virginia
Wisconsin
Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
Check Your Eligibility
Create a free profile and our AI will match you to COPD trials near you in North Carolina.
Get Matched — FreeNo insurance required
About COPD Trials
COPD trials investigate bronchodilators, anti-inflammatory biologics, pulmonary rehabilitation, and lung-volume reduction procedures for chronic obstructive lung disease.
All COPD trials →Other Conditions in North Carolina
Diabetes
Cancer
Breast Cancer
Depression
Anxiety
Alzheimer's
Heart Disease
Asthma
Multiple Sclerosis
Obesity
Parkinson's
Lupus
Hypertension
Stroke
Arthritis
Kidney Disease
COVID-19