Clinical Trials
for Hypertension in North Carolina
47 clinical trials for Hypertension are currently recruiting participants at study sites in North Carolina. Study-related care is provided at no cost.
Hypertension clinical trials in North Carolina: what to expect
High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.
In North Carolina, recruiting hypertension studies are concentrated in Durham, Chapel Hill, Winston-Salem and Monroe, with sites in 20 other cities. 25 of the 47 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who hypertension trials usually look for
Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.
What taking part involves
Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.
Showing 20 of 47 recruiting Hypertension trials in North Carolina
Where the Hypertension studies are in North Carolina
- Duke University Medical Center, Durham7 trials
- University of North Carolina at Chapel Hill, Chapel Hill5 trials
- Monroe Biomedical Research, Monroe4 trials
- Wake Forest University Health Sciences, Winston-Salem3 trials
- Duke University, Durham2 trials
- Duke University Hospital, Durham2 trials
- Durham22
- Chapel Hill13
- Winston-Salem11
- Monroe6
- Raleigh5
- Charlotte4
- Greensboro4
- Greenville4
Counts are recruiting studies listing at least one site in North Carolina, from ClinicalTrials.gov, refreshed every two days.
Hypertension clinical trials in North Carolina: common questions
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