Hypertension Trials / Trials in Missouri
22 Recruiting Trials

Clinical Trials
for Hypertension in Missouri

22 clinical trials for Hypertension are currently recruiting participants at study sites in Missouri. Study-related care is provided at no cost.

22
Recruiting trials
27
Study sites
8
Cities
18
Industry-sponsored
4
Phase 2
8
Phase 3

Hypertension clinical trials in Missouri: what to expect

High blood pressure trials focus on people whose pressure stays above target despite treatment. They test new classes of medicine, including once-daily pills and injections given every few months, procedures such as renal denervation for resistant hypertension, and programs built around home monitoring, diet and pharmacist-led care. Many are short, and some require no change to the medicines you already take.

In Missouri, recruiting hypertension studies are concentrated in St Louis, Kansas City, Columbia and Jefferson City, with sites in 4 other cities. 18 of the 22 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who hypertension trials usually look for

Trials set a blood pressure range measured at the site after rest, often on two separate visits, and state how many medicines you may already take: some want people on none, most want one to three, and resistant hypertension trials want three or more including a diuretic. Common exclusions are a known secondary cause, a recent heart attack or stroke, advanced kidney disease and pregnancy. Ages are usually 18 to 80.

What taking part involves

Screening includes blood pressure measurements, blood work and often a 24-hour wearable monitor. Some trials then standardize or pause your current medicines under supervision, while others add the study drug to them; the listing says which. Drug trials run eight to twelve weeks with visits every two to four weeks and home readings in between; placebo arms are common and rescue rules protect anyone whose pressure climbs. Procedure trials involve a day procedure and longer follow-up. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines change and who monitors you if they do; how the 24-hour monitor works; the chance of placebo and the rescue rules; and whether you keep the study medicine or return to your usual treatment afterwards.

Showing 20 of 22 recruiting Hypertension trials in Missouri

Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
PHASE2 Phoenix, Arizona +4 sites NCT07090161
This trial is looking for people with uncontrolled high blood pressure. Participants will take either the study drug or a placebo to see if it helps lower their blood pressure.
Recruiting
THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
NA Birmingham, Alabama +4 sites NCT06559891
This trial is looking for adults with hypertension who have not been able to control their blood pressure with medication. Participants will stop taking their blood pressure medications for a short time and receive either the TIVUS treatment or a sham procedure.
Recruiting
Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)
PHASE3 Fresno, California +4 sites NCT06274801
This trial is looking for adults who have completed a previous study with seralutinib. Participants will take seralutinib and be monitored for safety and effectiveness over time.
Recruiting
An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)
PHASE3 Scottsdale, Arizona +4 sites NCT07365332
This trial is looking for adults with a specific type of high blood pressure in the lungs called pulmonary arterial hypertension (PAH). Participants will take IKT-001 and be monitored for its effectiveness and safety.
Recruiting
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
PHASE3 Alexander City, Alabama +4 sites NCT07288398
This trial is looking for adults with pulmonary hypertension and heart failure. Participants will take either a medication called levosimendan or a placebo to see if it improves their walking distance.
Recruiting
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension
PHASE2 Alexander City, Alabama +4 sites NCT07142356
This trial is looking for adults with high blood pressure that is hard to control. Participants will take either the drug RTN-001 or a placebo (a dummy pill) every day for 12 weeks and visit the clinic for checkups.
Recruiting
HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction
PHASE1 Kansas City, Missouri +1 sites NCT07123779
This trial is looking for obese adults with pulmonary hypertension and heart failure. Participants will be evaluated for their symptoms and heart function before starting the trial treatment.
Recruiting
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
NA Birmingham, Alabama +4 sites NCT06911632
This trial is looking for adults who are at least 18 years old and have been diagnosed with a specific lung disease. They need to have a certain level of lung function that is low enough, but they can't already have been diagnosed with high blood pressure in the lungs or have certain heart conditions. It's also important that they haven't had a specific heart test in the last year and are generally healthy enough to participate.
Recruiting
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
N/A Birmingham, Alabama +4 sites NCT06388421
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
Recruiting
Pulmonary Hypertension Association Registry
N/A Phoenix, Arizona +4 sites NCT04071327
This trial is looking for people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Participants will provide information about their health and treatment to help improve care for these conditions.
Recruiting
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
NA Scottsdale, Arizona +4 sites NCT06059638
This trial is looking for people with high blood pressure who need a pacemaker. Participants will try a new treatment that adjusts heart rhythms to help lower blood pressure.
Recruiting
Global Paradise System US Post Approval Study
N/A Long Beach, California +4 sites NCT06297291
This trial is looking for adults with high blood pressure that isn't controlled by lifestyle changes or medications. Participants will receive treatment with the Paradise Ultrasound Renal Denervation System and help researchers understand its long-term safety and effectiveness.
Recruiting
An Open-label Extension Safety and Efficacy Study of QCZ484 in Hypertensive Patients.
PHASE2 Garden Grove, California +4 sites NCT07543120
This trial is looking for patients with high blood pressure who have completed an earlier study with the QCZ484 medication. Participants will continue to take QCZ484 and help researchers gather more information on its safety and effectiveness.
Recruiting
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
PHASE3 Fairhope, Alabama +4 sites NCT06742723
This trial is looking for adults with chronic kidney disease and high blood pressure. If you join, you will take medications to see how they affect your kidney health and heart-related risks.
Recruiting
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
PHASE3 Birmingham, Alabama +4 sites NCT07181109
This trial is looking for adults with high blood pressure that is not well controlled and have either a history of heart disease or are at high risk for heart disease. Participants will receive either the study drug, zilebesiran, or a placebo to see if it lowers the risk of serious heart-related events.
Recruiting
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
PHASE3 Anniston, Alabama +4 sites NCT07064473
This trial is looking for adults with type 2 diabetes, high blood pressure, and heart disease. Participants will take either the study medication or a placebo daily for up to 4 years.
Recruiting
A Study to Evaluate Efficacy and Safety of YSBP Compared to Lumigan in Patients With Glaucoma or Ocular Hypertension
PHASE3 Beverly Hills, California +4 sites NCT07661329
This trial is looking for adults with primary open-angle glaucoma or ocular hypertension. Participants will receive a preservative-free eye drop solution and must stop using other eye pressure medications before starting the trial.
Recruiting
Impact GLP-1 Agonists Following Bariatric
PHASE4 Columbia, Missouri NCT06132477
This trial is looking for adults who are planning to have weight loss surgery. Participants will either continue or stop taking a medication called GLP-1 agonists after their surgery and will help researchers understand the effects of this decision.
Recruiting
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
N/A Phoenix, Arizona +4 sites NCT04278404
This trial is looking for children and young adults who are 21 years old or younger and are currently taking certain medications, or who have had a recent COVID-19 infection. They cannot be pregnant or have had certain recent medical procedures like dialysis, organ transplants, or other serious treatments. If you think your child might fit this description, it could be worth considering.
Recruiting
Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage
N/A Irvine, California +4 sites NCT06402968
This trial is looking for adults who have high blood pressure after a stroke. Participants will receive either clevidipine or another treatment to help manage their blood pressure within 60 minutes.
Recruiting
See all 22 Hypertension trials in Missouri

Where the Hypertension studies are in Missouri

Research sites running the most studies
  • Washington University School of Medicine, St Louis3 trials
  • Jefferson City Medical Group, Jefferson City2 trials
  • CRO Call Center, Overland1 trial
  • Children's Mercy Hospital, Kansas City1 trial
  • Clinical Trial Site, Kansas City1 trial
  • Clinical Trial Site, St Louis1 trial
By city

Counts are recruiting studies listing at least one site in Missouri, from ClinicalTrials.gov, refreshed every two days.

Hypertension clinical trials in Missouri: common questions

How many Hypertension clinical trials are recruiting in Missouri?
TrialFinder currently lists 22 recruiting Hypertension clinical trials with study sites in Missouri. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Hypertension clinical trials located in Missouri?
Study sites for the Hypertension trials listed on this page include Kansas City, Columbia. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Hypertension clinical trial in Missouri?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Hypertension trials in Missouri also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Hypertension clinical trial in Missouri?
Each study sets its own criteria based on age, Hypertension diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I stop my blood pressure medicine to join a trial?
Some trials add the study drug to what you take; others standardize or pause your medicines for a few weeks under close monitoring, with rules for stepping in if pressure rises. The listing and consent form state which.
What is ambulatory blood pressure monitoring?
A small cuff and monitor worn for 24 hours that records readings automatically, including during sleep. Trials use it because it is more reliable than clinic readings; the site fits it and you return it the next day.
Is a high reading at home enough to qualify?
It is a reason to ask. Trials confirm eligibility with readings taken at the site after resting, usually on two visits, so a single home reading neither qualifies nor rules you out.
Hypertension Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Hypertension Trials

Hypertension trials study novel antihypertensives, renal denervation, lifestyle interventions, and combination therapies for resistant high blood pressure.

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