COPD Trials / Trials in Missouri
9 Recruiting Trials

Clinical Trials
for COPD in Missouri

9 clinical trials for COPD are currently recruiting participants at study sites in Missouri. Study-related care is provided at no cost.

9
Recruiting trials
15
Study sites
7
Cities
8
Industry-sponsored
3
Phase 2
6
Phase 3

COPD clinical trials in Missouri: what to expect

COPD trials test new inhaler combinations, biologic injections for people whose flare-ups continue despite inhalers, and treatments for the cough and mucus that come with chronic bronchitis. Others study pulmonary rehabilitation and exercise, valves and other procedures for emphysema, home oxygen and remote monitoring, and programs to stop smoking. Most enroll people with moderate to severe disease who still have symptoms on their current treatment.

In Missouri, recruiting copd studies are concentrated in St Louis, Hannibal, Chesterfield and Columbia, with sites in 3 other cities. 8 of the 9 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who COPD trials usually look for

Trials confirm COPD with a breathing test at screening and set a range for lung function, usually between 30 and 80 percent of predicted. Most ask for a smoking history of at least ten pack-years, though current smokers are generally accepted. Biologic trials require one or two flare-ups in the past year needing steroids or antibiotics and sometimes a blood eosinophil count above a threshold. Common exclusions are asthma as the main diagnosis, another significant lung disease and a flare-up in the past four weeks. Ages are usually 40 to 80.

What taking part involves

Screening includes spirometry, blood work and a symptom questionnaire, then a short run-in while you record symptoms. Drug trials run six to twelve months with visits every four to twelve weeks, breathing tests, a six-minute walk in some, and a diary or app. Your maintenance inhalers continue, sometimes replaced by study-supplied versions, and rescue inhaler is always allowed. Rehabilitation trials involve two or three sessions a week for eight to twelve weeks. Study care is free and visits are usually paid.

Questions worth asking the study team

Whether your inhalers stay the same; how breathing tests and walking tests are scheduled; the chance of placebo; what to do during a flare-up while enrolled; and whether oxygen users are accepted.

Showing 9 of 9 recruiting COPD trials in Missouri

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
PHASE3 Birmingham, Alabama +4 sites NCT06878261
This trial is looking for adults aged 40 to 80 who have had COPD for at least a year. Participants will take the study drug Tezepelumab and be monitored for its effects on their condition.
Recruiting
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
PHASE3 Foley, Alabama +4 sites NCT06883305
This trial is looking for adults with moderate to very severe COPD. Participants will be required to take part in assessments and treatments involving Tezepelumab.
Recruiting
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
PHASE4 Saint Charles, Missouri +1 sites NCT07816835
This trial is looking for patients with chronic obstructive pulmonary disease (COPD) who are not getting symptom relief from their current inhalers. Participants will switch from their inhaler to a nebulizer using similar medications to see if they feel better.
Recruiting
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
PHASE3 Athens, Alabama +4 sites NCT06283966
This trial is looking for adults aged 40 to 80 with Chronic Obstructive Pulmonary Disease (COPD). Participants will receive a combination inhaler treatment and attend study visits for assessments.
Recruiting
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
PHASE2 Birmingham, Alabama +4 sites NCT07082738
This trial is looking for people with moderate to very severe COPD to test the effects of a new drug called AZD6793. Participants will take AZD6793 or a placebo and help researchers learn about its safety and effectiveness.
Recruiting
Rademikibart IV for Acute Asthma and COPD Exacerbation
PHASE2 St Louis, Missouri +2 sites NCT07705737
This trial is looking for adults with asthma or COPD who are currently experiencing a serious flare-up. Participants will receive an intravenous treatment called rademikibart in addition to their usual care.
Recruiting
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
PHASE2 Birmingham, Alabama +4 sites NCT07363694
This trial is looking for adults aged 35 to 80 with moderate to severe COPD. Participants will receive either the study medicine PF-07275315 or a placebo through shots over 24 to 68 weeks and will attend multiple clinic visits during this time.
Recruiting
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation
PHASE3 Bakersfield, California +4 sites NCT06959095
This trial is looking for adults aged 40 to 80 with moderate to severe COPD and type 2 inflammation. Participants will take a new medicine called depemokimab to see how it helps manage their condition.
Recruiting
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
PHASE3 Birmingham, Alabama +4 sites NCT07190222
This trial is looking for adults aged 40 to 80 with chronic obstructive pulmonary disease (COPD) that is not well controlled. Participants will receive either lunsekimig or a placebo for about 48 weeks, followed by an 8-week follow-up.
Recruiting
See all 9 COPD trials in Missouri

Where the COPD studies are in Missouri

Research sites running the most studies
  • Research Site, St Louis3 trials
  • Research Site, Hannibal2 trials
  • Barnes-Jewish Hospital, St Louis1 trial
  • Barnes-Jewish Hospital Investigational Drug Service, St Louis1 trial
  • GSK Investigational Site, St Louis1 trial
  • Hannibal Regional Healthcare System- Site Number : 8400035, Hannibal1 trial
By city

Counts are recruiting studies listing at least one site in Missouri, from ClinicalTrials.gov, refreshed every two days.

COPD clinical trials in Missouri: common questions

How many COPD clinical trials are recruiting in Missouri?
TrialFinder currently lists 9 recruiting COPD clinical trials with study sites in Missouri. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are COPD clinical trials located in Missouri?
Study sites for the COPD trials listed on this page include Saint Charles, St Louis. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a COPD clinical trial in Missouri?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many COPD trials in Missouri also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a COPD clinical trial in Missouri?
Each study sets its own criteria based on age, COPD diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need to quit smoking to join a COPD trial?
Most COPD trials accept current smokers; some require that you have stopped, and smoking-cessation trials are specifically for people who still smoke. The listing states the rule.
What tests confirm COPD for a trial?
Spirometry, a breathing test done at the site before and after a bronchodilator, which gives the lung function figure trials use to set their range. You do not need recent results to ask.
Will I keep using my inhalers during a trial?
Yes. Trials add the study treatment to your maintenance inhalers or supply a standardized equivalent, and a rescue inhaler is always permitted.
COPD Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About COPD Trials

COPD trials investigate bronchodilators, anti-inflammatory biologics, pulmonary rehabilitation, and lung-volume reduction procedures for chronic obstructive lung disease.

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