Clinical Trials
for Lupus in Missouri
12 clinical trials for Lupus are currently recruiting participants at study sites in Missouri. Study-related care is provided at no cost.
Lupus clinical trials in Missouri: what to expect
Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.
In Missouri, recruiting lupus studies are concentrated in St Louis, Kansas City, City of Saint Peters and Creve Coeur, with sites in 3 other cities. 8 of the 12 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who lupus trials usually look for
Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.
What taking part involves
Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.
Showing 12 of 12 recruiting Lupus trials in Missouri
Where the Lupus studies are in Missouri
- Research Site, St Louis2 trials
- Washington University School of Medicine, St Louis2 trials
- H03- Washington University School of Medicine, St Louis1 trial
- Investigative Site, Saint Joseph1 trial
- Kansas City Physician Partners, Kansas City1 trial
- Research Site, Kansas City1 trial
Counts are recruiting studies listing at least one site in Missouri, from ClinicalTrials.gov, refreshed every two days.
Lupus clinical trials in Missouri: common questions
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