Lupus Trials / Trials in Nebraska
5 Recruiting Trials

Clinical Trials
for Lupus in Nebraska

5 clinical trials for Lupus are currently recruiting participants at study sites in Nebraska. Study-related care is provided at no cost.

5
Recruiting trials
2
Study sites
1
City
5
Industry-sponsored
2
Phase 2
1
Phase 3

Lupus clinical trials in Nebraska: what to expect

Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.

In Nebraska, recruiting lupus studies are concentrated in Omaha. 5 of the 5 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who lupus trials usually look for

Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.

What taking part involves

Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.

Questions worth asking the study team

Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.

Showing 5 of 5 recruiting Lupus trials in Nebraska

Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
PHASE2 Phoenix, Arizona +4 sites NCT05268289
This trial is looking for people with active lupus nephritis. Participants will take a medication called LNP023 along with their usual treatment to see how well it works and how safe it is.
Recruiting
A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis
PHASE2 Beverly Hills, California +4 sites NCT07570862
This trial is looking for people with lupus nephritis who have not responded well to previous treatments. Participants will receive a new therapy, FT819, to see if it helps improve kidney function over 26 weeks.
Recruiting
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
PHASE1 Anniston, Alabama +4 sites NCT06916806
This trial is looking for adults with Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, or Rheumatoid Arthritis. Participants will receive the study drug AZD5492 either once or twice during the trial period and will attend several check-up visits over at least 180 days.
Recruiting
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
PHASE3 Phoenix, Arizona +4 sites NCT07691970
This trial is looking for people who have finished another study with anifrolumab and are still benefiting from it. Participants will continue to receive anifrolumab and will be monitored for safety.
Recruiting
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
PHASE1 Beverly Hills, California +4 sites NCT06308978
This trial is looking for people between the ages of 12 and 70 who have certain autoimmune diseases that are not responding to previous treatments. They should generally be in good health, but not have serious heart or lung problems, active infections, or recent cancer. Also, women can't be pregnant or breastfeeding, and participants need to weigh at least 50 kg.
Recruiting
See all 5 Lupus trials in Nebraska

Where the Lupus studies are in Nebraska

Research sites running the most studies
  • University of Nebraska Medical Center, Omaha3 trials
  • Research Site, Omaha2 trials
By city

Counts are recruiting studies listing at least one site in Nebraska, from ClinicalTrials.gov, refreshed every two days.

Lupus clinical trials in Nebraska: common questions

How many Lupus clinical trials are recruiting in Nebraska?
TrialFinder currently lists 5 recruiting Lupus clinical trials with study sites in Nebraska. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in Nebraska?
Sites for these Lupus trials are spread across Nebraska. Open any trial to see its full list of participating locations and contact details.
Do I need insurance to join a Lupus clinical trial in Nebraska?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in Nebraska also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in Nebraska?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
Lupus Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Lupus Trials

Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.

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