20 Recruiting Trials
Clinical Trials
for Lupus in Pennsylvania
20 clinical trials for Lupus are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.
20
Recruiting trials
23
Study sites
6
Cities
12
Industry-sponsored
9
Phase 2
5
Phase 3
Lupus clinical trials in Pennsylvania: what to expect
Lupus trials are mostly for systemic lupus that stays active despite standard treatment. They test biologic infusions and injections that target the immune signals behind lupus, new oral medicines, and treatments that reduce the need for steroids. Lupus nephritis, where the disease affects the kidneys, has its own trials with their own entry rules, and cell-based therapies are beginning to be tested in people whose lupus has not responded to anything else.
In Pennsylvania, recruiting lupus studies are concentrated in Philadelphia, Pittsburgh, Hershey and Allentown, with sites in 2 other cities. 12 of the 20 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who lupus trials usually look for
Trials require a confirmed diagnosis with positive antibody tests, active disease above a threshold on a standard activity score at screening, and a stable regimen of your current medicines (an antimalarial, an immunosuppressant, a steroid below a stated dose) for several weeks beforehand. Lupus nephritis trials need a recent kidney biopsy and a protein-in-urine level above a cut-off. Common exclusions are severe active lupus of the brain, a recent biologic, serious infection and pregnancy. Ages are usually 18 to 75.
What taking part involves
Screening includes blood and urine tests and a review of your records. Most trials then last a year with visits every four weeks for an infusion or injection, lab monitoring and a disease-activity exam, often with a plan to taper steroids. The study drug is usually compared with placebo, both added to your existing treatment, and flares are treated as needed. An open-label extension generally follows. All study care is free and visits are usually paid.
Questions worth asking the study team
Whether your current medicines stay unchanged; how the steroid taper works; the chance of placebo and whether an extension follows; what happens during a flare; and what the trial means for pregnancy planning.
Showing 20 of 20 recruiting Lupus trials in Pennsylvania
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
Recruiting
This trial is looking for people aged 16 and older who have moderate to severe systemic lupus erythematosus (SLE) and are not getting enough improvement from their current medications. Participants will receive dapirolizumab pegol as an additional treatment along with their existing medications.
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
Recruiting
This trial is looking for people with systemic lupus erythematosus who have completed a previous study using ianalumab. Participants will be monitored for long-term safety and tolerance of the treatment.
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
Recruiting
This trial is looking for children with moderate to severe systemic lupus erythematosus (SLE) to test a treatment called Anifrolumab. Participants will be monitored to understand how well the treatment works and its safety.
A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus
Recruiting
This trial is looking for adults with moderate to severe lupus. Participants will receive either the drug nipocalimab or a placebo to see how well it works.
Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease
Recruiting
This trial is looking for older adults with lupus who want to see if they can safely stop taking hydroxychloroquine. Participants will be monitored for one year to check their disease activity.
A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)
Recruiting
This trial is looking for adults with systemic lupus erythematosus (SLE) to see if a medicine called BI 3000202 can help them. Participants will take the medicine or a placebo for one year while continuing their regular SLE treatment.
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
Recruiting
This trial is looking for teenagers aged 12 to 18 and children aged 5 to under 12 who have been diagnosed with lupus nephritis. Participants will receive treatment with obinutuzumab and be monitored for safety and effectiveness.
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
Recruiting
This trial is looking for adults with active systemic lupus erythematosus or lupus nephritis. Participants will receive the treatment CABA-201 and will be monitored for safety and effectiveness.
Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
Recruiting
This trial is looking for people with active lupus nephritis. Participants will take a medication called LNP023 along with their usual treatment to see how well it works and how safe it is.
A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis
Recruiting
This trial is looking for people aged 16-70 who have systemic lupus erythematosus that hasn't responded to treatment. Participants will receive a special infusion after a preparatory treatment to help their condition.
VIBRANT: VIB4920 for Active Lupus Nephritis
Recruiting
This trial is looking for adults with active lupus nephritis. Participants will take VIB4920 along with other medications to see if it helps improve kidney function.
A Study of Quinacrine in Participants With Cutaneous Lupus Erythematosus
Recruiting
This trial is looking for adults with cutaneous lupus erythematosus who want to try quinacrine, a medication that may help with skin symptoms. Participation lasts about 28 weeks and includes receiving either quinacrine or a placebo.
PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis
Recruiting
This trial is looking for adults with lupus nephritis who want to test a new combination treatment. Participants will need to take some specific medications and be within a certain age range.
A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants
Recruiting
This trial is looking for people with active systemic lupus erythematosus who have not responded well to previous treatments. Participants will need to meet specific health criteria and may undergo assessments to evaluate their condition.
Prevalence and Clinical Severity of Cutaneous Lupus Erythematosus
Recruiting
This trial is looking for adults with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE). Participants will be involved in a database study to help understand this condition better.
Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
Recruiting
This trial is looking for children and young adults with severe autoimmune diseases like systemic lupus erythematosus or systemic sclerosis. Participants will receive high-dose therapy followed by a stem cell transplant to help reset their immune system.
CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus
Recruiting
This trial is looking for children and young adults aged 12 to 29 who have severe lupus that hasn't responded to other treatments. Participants will receive a new type of cell therapy called CART19 and will be monitored for safety and effectiveness.
Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study
Recruiting
This trial is looking for adults with chronic pain to compare two different treatments: an 8-week program of cognitive behavioral therapy and a one-time pain relief skills session. Participants will either take part in the longer therapy or the shorter session.
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Recruiting
This trial is looking for adults with advanced cancers who also have autoimmune disorders. Participants will receive treatments that may include the drug nivolumab and possibly others to see how well they work together.
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Recruiting
This trial is looking for people between the ages of 12 and 70 who have certain autoimmune diseases that are not responding to previous treatments. They should generally be in good health, but not have serious heart or lung problems, active infections, or recent cancer. Also, women can't be pregnant or breastfeeding, and participants need to weigh at least 50 kg.
Where the Lupus studies are in Pennsylvania
Research sites running the most studies
- Children's Hospital of Philadelphia, Philadelphia2 trials
- Allegheny Health Network, Pittsburgh1 trial
- Altoona Arthritis & Osteoporosis Center - Altoona Center for Clinical Research, Duncansville1 trial
- Children's Hospital of Philadelphia - Accepting Young Adult and Adolescent Patients, Philadelphia1 trial
- Chldren?s Hospital of Philadelphia, Philadelphia1 trial
- Clinical Research Philadelphia, Philadelphia1 trial
By city
Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.
Lupus clinical trials in Pennsylvania: common questions
How many Lupus clinical trials are recruiting in Pennsylvania?
TrialFinder currently lists 20 recruiting Lupus clinical trials with study sites in Pennsylvania. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Lupus clinical trials located in Pennsylvania?
Study sites for the Lupus trials listed on this page include Philadelphia, Allentown. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Lupus clinical trial in Pennsylvania?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Lupus trials in Pennsylvania also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Lupus clinical trial in Pennsylvania?
Each study sets its own criteria based on age, Lupus diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will my regular lupus medicines stop if I join a trial?
No. Lupus trials add the study treatment to a stable regimen of your current medicines. Many include a planned steroid taper as one of the goals, managed by the study doctor.
Is there a placebo in lupus trials?
Usually, but always on top of standard treatment, never instead of it, and most trials move everyone onto the active drug in an extension after the main study period.
Can I join a trial if I have lupus nephritis?
Yes. Lupus nephritis has dedicated trials that require a recent kidney biopsy and a stated level of protein in the urine. General lupus trials often exclude active nephritis, so look for the ones that name it.
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Lupus Trials
Lupus trials evaluate belimumab, anifrolumab, JAK inhibitors, and other biologics targeting the immune dysregulation behind systemic lupus erythematosus.
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