29 Recruiting Trials
Clinical Trials
for Anxiety in Pennsylvania
29 clinical trials for Anxiety are currently recruiting participants at study sites in Pennsylvania. Study-related care is provided at no cost.
29
Recruiting trials
34
Study sites
14
Cities
7
Industry-sponsored
5
Phase 2
1
Phase 3
Anxiety clinical trials in Pennsylvania: what to expect
Anxiety trials study generalized anxiety disorder, social anxiety, panic disorder and often post-traumatic stress alongside them. The treatments under study range from new medicines and repurposed ones to cognitive behavioral therapy delivered in person, by video or through an app, virtual-reality exposure, and brain stimulation. Many are run by universities and some can be completed largely online, with a small number of in-person visits.
In Pennsylvania, recruiting anxiety studies are concentrated in Philadelphia, Hershey, Pittsburgh and Allentown, with sites in 10 other cities. 7 of the 29 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who anxiety trials usually look for
Trials name the diagnosis they study and set a minimum symptom score on a standard questionnaire, confirmed by a clinician interview at screening. Adults 18 to 65 are the usual range, with separate studies for teenagers and older adults. Typical exclusions are bipolar disorder, psychosis, a current substance use disorder and, for some medicine trials, daily benzodiazepine use. Stable antidepressant treatment is often allowed.
What taking part involves
After a screening interview, medicine trials run eight to twelve weeks with visits every one to two weeks, questionnaires and sometimes blood work; placebo arms are common. Therapy trials involve weekly sessions for eight to sixteen weeks, often with a comparison group that gets the program later. Some studies add brain imaging or a wearable to track sleep and heart rate. Everything study-related is free, and most trials pay for your time.
Questions worth asking the study team
Which visits must be in person; whether you can continue your current medicine or therapy; the chance of placebo or of a waiting-list group; and what support is available if symptoms get worse during the study.
Showing 20 of 29 recruiting Anxiety trials in Pennsylvania
A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
Recruiting
This trial is looking for adults with generalized anxiety disorder. Participants will take a daily dose of SEP-363856 or a placebo for 8 weeks while monitoring their response to the treatment.
Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder
Recruiting
This trial is looking for adults with Generalized Anxiety Disorder (GAD) who have not responded well to their current GAD treatment. Participants will take a new medication, ITI-1284, alongside their ongoing treatment.
Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder
Recruiting
This trial is looking for people with moderate or severe generalized anxiety disorder (GAD) who haven't responded well to previous treatments. Participants will take ITI-1284 and help researchers understand its effects on anxiety.
RE104 Safety and Efficacy Study in Generalized Anxiety Disorder
Recruiting
This trial is looking for people with Generalized Anxiety Disorder (GAD) to see if a single injection of RE104 can help reduce their anxiety symptoms. Participants will be compared to those receiving a placebo, which is an inactive treatment.
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
Recruiting
This trial is looking for adults with generalized anxiety disorder (GAD) who have not had enough relief from their current antidepressant medications. Participants will take capsules of either ABBV-932 or a placebo for 6 weeks, along with their existing treatment, and attend regular check-up visits to monitor their progress.
A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder
Recruiting
This trial is looking for adults aged 18 to 65 who have social anxiety disorder. Participants will use a nasal spray to help relieve anxiety symptoms caused by public speaking challenges.
Brief Smartphone Treatment Study
Recruiting
This trial is looking for adults with Generalized Anxiety Disorder who want to try mindfulness training using a smartphone app. Participants will practice mindfulness strategies for 14 days and share their experiences through self-reports and assessments.
Brain Activity Changes After Cognitive Behavioral Therapy for Anxiety in Autistic Youth From High-Need Communities
Recruiting
This trial is looking for autistic youth aged 8 to 14 who have anxiety. Participants will either start a treatment called Facing Your Fears right away or wait and continue their usual treatment before starting it.
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
Recruiting
This trial is looking for adult patients in the Surgical Intensive Care Unit to test the use of virtual reality to help reduce anxiety and agitation. Taking part involves using a virtual reality headset with calming content during your time in the ICU.
Virtual Reality as a Method for Pain and Anxiety Control During First Trimester Procedural Abortion
Recruiting
This trial is looking for women who are planning to have an abortion within the first trimester. Participants will either use a virtual reality headset with a calming video or receive standard care during the procedure to see how it affects pain and anxiety.
A Study Comparing Music Therapy and Cognitive Behavioral Therapy for Anxiety in Cancer Survivors
Recruiting
This trial is looking for people who have survived cancer and are experiencing anxiety. Participants will compare the effects of music therapy and cognitive behavioral therapy through online sessions.
Recruiting
Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms
Recruiting
This trial is looking for young adults aged 18-25 who feel anxious or depressed and have trouble sleeping. Participants will spend two nights in a sleep lab and wear a headband that plays sounds while they sleep to see if it helps improve their mood and sleep.
Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students
Recruiting
This trial is looking for high school students aged 13-18 in rural Schuylkill County, Pennsylvania. Participants will receive cognitive-behavioral therapy from college students to help with depression, stress, and anxiety.
Safe & Sound Protocol in Adults With Trauma and SUD
Recruiting
This trial is looking for adults who are in treatment for substance use and have a history of trauma. Participants will use the Safe and Sound Protocol app for about 3 to 5 hours over a week while continuing their usual treatment.
Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program
Recruiting
This trial is looking for young people aged 11-14 who are from low-income families and need help with mental health issues like depression and anxiety. Participants will take part in a program designed to improve their coping skills and mental well-being.
Decoding and Modulating Affective Brain States
Recruiting
This trial is looking for adults aged 18-65 who experience anxiety or depression. Participants will undergo brain imaging and receive brain stimulation to see if it helps reduce negative emotions.
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
Recruiting
This trial is looking for adults who are scheduled for knee or hip surgery and have moderate mood disorder symptoms. Participants will use the RxWell platform to help manage their mood around the time of surgery.
Telehealth Collaborative Care Model (CoCM) in Lung Cancer
Recruiting
This trial is looking for adults with lung cancer who need help managing anxiety or depression. Participants will take part in a telehealth program to improve their mental health through collaborative care.
Where the Anxiety studies are in Pennsylvania
Research sites running the most studies
- Drexel University, Philadelphia2 trials
- Neuronetics, Malvern2 trials
- Penn State College of Medicine, Hershey2 trials
- Suburban Research Associates, Media2 trials
- University of Pennsylvania, Philadelphia2 trials
- Abramson Cancer Center at the University of Pennsylvania, Philadelphia1 trial
By city
Counts are recruiting studies listing at least one site in Pennsylvania, from ClinicalTrials.gov, refreshed every two days.
Anxiety clinical trials in Pennsylvania: common questions
How many Anxiety clinical trials are recruiting in Pennsylvania?
TrialFinder currently lists 29 recruiting Anxiety clinical trials with study sites in Pennsylvania. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Anxiety clinical trials located in Pennsylvania?
Study sites for the Anxiety trials listed on this page include University Park, Philadelphia, Hershey, Pittsburgh, Wernersville, Harrisburg. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Anxiety clinical trial in Pennsylvania?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Anxiety trials in Pennsylvania also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Anxiety clinical trial in Pennsylvania?
Each study sets its own criteria based on age, Anxiety diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I take part in an anxiety trial if I am already in therapy?
Often yes for medicine trials, if the therapy is ongoing and stable. Trials testing a therapy usually ask that you are not starting another one at the same time. The listing states its rule.
Are there anxiety studies I can do online?
Yes. Many app-based and video-therapy studies are mostly remote, though most still need one or two in-person visits, so distance to the site still matters.
Is there a placebo in anxiety trials?
Medicine trials usually include a placebo arm and say so in the consent form. Therapy trials compare against usual care or a group that receives the program after a delay.
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Anxiety Trials
Anxiety disorder trials study CBT approaches, novel anxiolytics, MDMA-assisted therapy, and neuromodulation techniques for GAD, social anxiety, and PTSD.
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