Anxiety Trials / Trials in California
57 Recruiting Trials

Clinical Trials
for Anxiety in California

57 clinical trials for Anxiety are currently recruiting participants at study sites in California. Study-related care is provided at no cost.

57
Recruiting trials
95
Study sites
39
Cities
10
Industry-sponsored
11
Phase 2
3
Phase 3

Anxiety clinical trials in California: what to expect

Anxiety trials study generalized anxiety disorder, social anxiety, panic disorder and often post-traumatic stress alongside them. The treatments under study range from new medicines and repurposed ones to cognitive behavioral therapy delivered in person, by video or through an app, virtual-reality exposure, and brain stimulation. Many are run by universities and some can be completed largely online, with a small number of in-person visits.

In California, recruiting anxiety studies are concentrated in Los Angeles, San Francisco, Oceanside and San Diego, with sites in 35 other cities. 10 of the 57 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who anxiety trials usually look for

Trials name the diagnosis they study and set a minimum symptom score on a standard questionnaire, confirmed by a clinician interview at screening. Adults 18 to 65 are the usual range, with separate studies for teenagers and older adults. Typical exclusions are bipolar disorder, psychosis, a current substance use disorder and, for some medicine trials, daily benzodiazepine use. Stable antidepressant treatment is often allowed.

What taking part involves

After a screening interview, medicine trials run eight to twelve weeks with visits every one to two weeks, questionnaires and sometimes blood work; placebo arms are common. Therapy trials involve weekly sessions for eight to sixteen weeks, often with a comparison group that gets the program later. Some studies add brain imaging or a wearable to track sleep and heart rate. Everything study-related is free, and most trials pay for your time.

Questions worth asking the study team

Which visits must be in person; whether you can continue your current medicine or therapy; the chance of placebo or of a waiting-list group; and what support is available if symptoms get worse during the study.

Showing 20 of 57 recruiting Anxiety trials in California

A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder
PHASE3 Redlands, California +4 sites NCT07767903
This trial is looking for adults with generalized anxiety disorder. Participants will take a daily dose of SEP-363856 or a placebo for 8 weeks while monitoring their response to the treatment.
Recruiting
A Study to Asses Safety and Tolerability of ITI-1284 Given Alone or as an Additional Treatment in Participants With Generalized Anxiety Disorder (GAD)
PHASE3 Los Angeles, California +2 sites NCT07807865
This trial is looking for adults with generalized anxiety disorder who have not responded to previous treatments. Participants will take a medication called ITI-1284, either alone or with other treatments, to help assess its safety and tolerability.
Recruiting
Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder
PHASE2 Glendale, California +4 sites NCT06480383
This trial is looking for adults with Generalized Anxiety Disorder (GAD) who have not responded well to their current GAD treatment. Participants will take a new medication, ITI-1284, alongside their ongoing treatment.
Recruiting
Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder
PHASE2 Culver City, California +4 sites NCT06701903
This trial is looking for people with moderate or severe generalized anxiety disorder (GAD) who haven't responded well to previous treatments. Participants will take ITI-1284 and help researchers understand its effects on anxiety.
Recruiting
RE104 Safety and Efficacy Study in Generalized Anxiety Disorder
PHASE2 Garden Grove, California +4 sites NCT07489651
This trial is looking for people with Generalized Anxiety Disorder (GAD) to see if a single injection of RE104 can help reduce their anxiety symptoms. Participants will be compared to those receiving a placebo, which is an inactive treatment.
Recruiting
A Study of NTX-1472 in Social Anxiety Disorder
PHASE2 Encino, California +4 sites NCT07323784
This trial is looking for adults with Social Anxiety Disorder. Participants will take a study treatment or a placebo every day for 8 weeks and attend 6 clinic visits for checkups and tests over 14 weeks.
Recruiting
Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
PHASE2 Anaheim, California +4 sites NCT06846320
This trial is looking for adults with generalized anxiety disorder (GAD) who have not had enough relief from their current antidepressant medications. Participants will take capsules of either ABBV-932 or a placebo for 6 weeks, along with their existing treatment, and attend regular check-up visits to monitor their progress.
Recruiting
A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder
PHASE2 Sherman Oaks, California +4 sites NCT06809179
This trial is looking for adults aged 18 to 65 who have social anxiety disorder. Participants will use a nasal spray to help relieve anxiety symptoms caused by public speaking challenges.
Recruiting
Very Brief Exposure: Development of a Novel Exposure Modality for Social Anxiety Disorder in Transition-Age Youth
NA Los Angeles, California NCT06526260
This trial is looking for young people aged 16-22 who have social anxiety disorder. Participants will answer questions and see images while undergoing an MRI scan to help researchers understand how this condition affects the brain.
Recruiting
Personalized AI-Driven Models in Cognitive Behavioral Therapy for Anxiety
NA Los Angeles, California NCT07430800
This trial is looking for college students with anxiety to participate in a study using robots that help with therapy exercises. Participants will receive personalized support to improve their therapy compliance and reduce anxiety.
Recruiting
Decentralized Study to Evaluate a Dietary Supplement for Episodes of Mild Acute Stress in Healthy People
NA San Francisco, California NCT07511088
This trial is looking for healthy adults who experience mild stress or anxiety episodes. Participants will take a dietary supplement or a placebo and report their feelings of anxiety after stressful situations over a few weeks.
Recruiting
Reward Processing and Exposure Therapy for Social Anxiety Disorder
NA Los Angeles, California +1 sites NCT06776991
This trial is looking for people who are anxious in social situations and specifically afraid of public speaking. Participants will try two different treatments to help improve their mood or relaxation before undergoing exposure therapy.
Recruiting
Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)
NA Los Angeles, California +2 sites NCT04557891
This trial is looking for adults with generalized anxiety disorder who have not found relief from standard treatments. Participants will receive focused ultrasound treatment for their anxiety over four sessions.
Recruiting
Sensory Adapted Dental Environments to Enhance Oral Care for Children With and Without Dental Fear and Anxiety
NA Los Angeles, California NCT06912854
This trial is looking for children aged 6 to 12 with or without dental anxiety. Participants will experience different dental environments to see which one helps reduce their anxiety and discomfort during dental cleanings.
Recruiting
Phase II: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings
NA Monterey, California +1 sites NCT07155707
This trial is looking for children with anxiety or mood disorders to participate in virtual therapy using the Teleo platform. Participants will compare this online therapy to traditional video sessions.
Recruiting
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
PHASE2 San Diego, California NCT06273527
This trial is looking for adults with anxiety, depression, or trauma-related symptoms. Participants will take part in computer-based cognitive training and complete tasks to measure their thinking abilities and brain responses.
Recruiting
K08 VR Fear Conditioning
NA Los Angeles, California NCT07216222
Recruiting
Tactile Pre-Visit Imagery
NA Los Angeles, California +1 sites NCT07719205
This trial is looking for children aged 4-10 who have never received dental treatment before. Participants will use a special booklet to help reduce fear before their first dental filling or crown procedure.
Recruiting
Interoceptive Training Enhanced Mindfulness
NA San Diego, California NCT06786572
Recruiting
VR AI Meditation for Pain
NA Los Angeles, California NCT07122843
Recruiting
See all 57 Anxiety trials in California

Where the Anxiety studies are in California

Research sites running the most studies
  • Children's Hospital Los Angeles, Los Angeles5 trials
  • Stanford University, Stanford3 trials
  • Anderson Clinical Research, Redlands2 trials
  • CalNeuro Research, Los Angeles2 trials
  • City of Hope Medical Center, Duarte2 trials
  • City of Hope at Irvine Lennar, Irvine2 trials
By city

Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.

Anxiety clinical trials in California: common questions

How many Anxiety clinical trials are recruiting in California?
TrialFinder currently lists 57 recruiting Anxiety clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Anxiety clinical trials located in California?
Study sites for the Anxiety trials listed on this page include Redlands, Los Angeles, Glendale, Culver City, Garden Grove, Encino. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Anxiety clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Anxiety trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Anxiety clinical trial in California?
Each study sets its own criteria based on age, Anxiety diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Can I take part in an anxiety trial if I am already in therapy?
Often yes for medicine trials, if the therapy is ongoing and stable. Trials testing a therapy usually ask that you are not starting another one at the same time. The listing states its rule.
Are there anxiety studies I can do online?
Yes. Many app-based and video-therapy studies are mostly remote, though most still need one or two in-person visits, so distance to the site still matters.
Is there a placebo in anxiety trials?
Medicine trials usually include a placebo arm and say so in the consent form. Therapy trials compare against usual care or a group that receives the program after a delay.
Anxiety Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Anxiety Trials

Anxiety disorder trials study CBT approaches, novel anxiolytics, MDMA-assisted therapy, and neuromodulation techniques for GAD, social anxiety, and PTSD.

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