62 Recruiting Trials

Clinical Trials
for Stroke in California

62 clinical trials for Stroke are currently recruiting participants at study sites in California. Study-related care is provided at no cost.

62
Recruiting trials
121
Study sites
48
Cities
23
Industry-sponsored
8
Phase 2
9
Phase 3

Stroke clinical trials in California: what to expect

Stroke trials come in three kinds. Acute treatment trials enroll within hours of a stroke, inside the hospital, and are not something you apply to. Recovery and rehabilitation trials enroll from a few weeks to many years after a stroke and test intensive therapy, robotics, brain and nerve stimulation, virtual reality and medicines meant to help the brain rewire. Prevention trials test blood thinners, cholesterol and blood pressure treatments and procedures to lower the chance of a second stroke.

In California, recruiting stroke studies are concentrated in Los Angeles, San Francisco, Sacramento and Downey, with sites in 44 other cities. 23 of the 62 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who stroke trials usually look for

Listings state the time since stroke, the type (a clot or a bleed) and the kind of difficulty they study, such as arm and hand weakness, walking, speech or vision, often with a range on a standard scale that the study therapist scores. Many recovery trials enroll people six months or more after their stroke, so an older stroke does not rule you out. Prevention trials look for a stroke or mini-stroke in a recent window plus a specific risk factor such as atrial fibrillation. Most require that you can give consent and take part in sessions.

What taking part involves

Rehabilitation trials are intensive: several sessions a week for four to twelve weeks, with assessments by a therapist before, after and some months later, and sometimes an MRI. The comparison group often receives standard therapy or the same program later. Prevention trials are long and light: a study medicine or placebo added to usual care, visits every few months for several years. Study care and equipment are free and travel is usually reimbursed; a family member is welcome at visits.

Questions worth asking the study team

How many sessions are required and where; whether a comparison group receives the therapy later; whether current rehabilitation can continue; what the assessments involve; and whether transport can be arranged.

Showing 20 of 62 recruiting Stroke trials in California

Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
PHASE2 Arcadia, California +4 sites NCT05065216
This trial is looking for adults who have had a moderate stroke and present within 24 hours of the onset. Participants will receive a study medication to see if it helps improve their condition.
Recruiting
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
PHASE4 Los Angeles, California +4 sites NCT03968393
This trial is looking for people who have had recent episodes of atrial fibrillation caused by stress. Participants will be involved in comparing anticoagulation treatment with no treatment to see which is better for preventing strokes.
Recruiting
Telerehabilitation In The Home After Stroke
NA Downey, California +4 sites NCT06682429
This trial is looking for people who have arm weakness from a stroke that happened 90 to 150 days ago. Participants will receive telerehabilitation to improve their arm function, alongside usual care, for 6 weeks.
Recruiting
kTMP-Enhanced Motor Rehabilitation for Chronic Stroke Recovery (KULMINATE) Pilot
NA San Francisco, California NCT07631078
This trial is looking for adults aged 18-80 who have had a stroke at least a year ago. Participants will use a special treatment to help improve arm and hand movement.
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NA La Jolla, California +4 sites NCT03821129
This trial is looking for patients who have had a recent stroke and also have a condition called Patent Foramen Ovale (PFO). Participants will receive a device to help reduce the risk of future strokes.
Recruiting
EEG Changes and DNA Markers Related to taVNS in Stroke Patients: a Preliminary Study
NA Pomona, California NCT06226493
This trial is looking for people who have had a stroke within the last month and have motor impairments. Participants will receive either active treatment or a placebo while we measure changes in brain activity and recovery.
Recruiting
Cognition and Motor Learning Post-stroke
EARLY_PHASE1 Los Angeles, California NCT04829071
This trial is looking for older adults who have experienced a stroke more than six months ago. Participants will help researchers understand how thinking skills affect walking abilities after a stroke.
Recruiting
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
N/A Los Angeles, California +4 sites NCT05911568
This trial is looking for adults who had a stroke and have moderate to severe disability before it. Participants will compare two treatment options: a procedure to remove blood clots or regular medical care without the procedure.
Recruiting
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
N/A Los Angeles, California +4 sites NCT05338697
This trial is looking for adults who have had a stroke and are experiencing motor difficulties in one arm. Participants will undergo specific tests and procedures to help researchers understand recovery outcomes.
Recruiting
Examining Relationships Between Musculoskeletal Function Measurements of Movement Efficiency and Nervous System Function After Chronic Stroke
N/A Sacramento, California NCT07737873
This trial is looking for adults who have had a stroke more than 3 months ago. Participants will help researchers understand relationships between physical function, nervous system function, and quality of life after stroke.
Recruiting
Diagnostic Performance Study of the EMVision Emu™ Brain Scanner in the Detection of Intracranial Hemorrhage in Suspected Stroke Patients
N/A Los Angeles, California +4 sites NCT06999122
This trial is looking for adults suspected of having a stroke. Participants will undergo a scan with a new device designed to quickly detect bleeding in the brain.
Recruiting
Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
N/A Los Angeles, California NCT05518305
This trial is looking for people who have had a stroke or TIA to see if a specific platelet test can help predict future strokes. Participants will share their health information and undergo imaging tests.
Recruiting
Driver Simulator Training to Improve Driving After Stroke
N/A Sacramento, California NCT06672107
Recruiting
Stroke Thrombectomy and Aneurysm Registry
N/A Loma Linda, California +4 sites NCT04994756
This trial is looking for patients undergoing surgery for brain injuries. Participants will help collect information about their treatment and outcomes.
Recruiting
Stroke Recovery Initiative - Registry for Stroke Research Studies
N/A San Francisco, California NCT03318432
This trial is looking for people who have had a stroke and are experiencing ongoing symptoms. Participants will connect with researchers working on ways to improve recovery after a stroke.
Recruiting
StrokeCog-BBB to Study Cognitive Outcomes Following Stroke
N/A Palo Alto, California NCT06116630
Recruiting
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
PHASE3 Glendale, California +4 sites NCT05611242
This trial is looking for adults aged 18 to 79 who have had an acute ischemic stroke. Participants will receive a specific treatment for blocked arteries in the brain to see if it's more effective than other approaches.
Recruiting
Optimizing Reperfusion to Improve Outcomes and Neurologic Function
PHASE2 Long Beach, California +4 sites NCT06990867
This trial is looking for adults with acute ischemic stroke who seek care within 4.5 to 24 hours. Participants will receive either a new treatment called JX10 or a placebo to see how it affects recovery and safety.
Recruiting
Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke
PHASE3 Carmichael, California +4 sites NCT05691244
This trial is looking for adults who have had an acute ischemic stroke. Participants will receive a new treatment called sovateltide along with standard care and will be monitored for safety and effectiveness.
Recruiting
Strategy for Improving Stroke Treatment Response
PHASE2 La Jolla, California +4 sites NCT05948566
This trial is looking for adults who have had a suspected ischemic stroke. Participants will receive a treatment called TS23 to see how safe and effective it is within a specific time after their stroke.
Recruiting

Where the Stroke studies are in California

  • Cedars-Sinai Medical Center, Los Angeles6 trials
  • Kaiser Permanente Los Angeles Medical Center, Los Angeles6 trials
  • Ronald Reagan UCLA Medical Center, Los Angeles6 trials
  • Rancho Research Institute, Downey3 trials
  • San Francisco General Hospital, San Francisco3 trials
  • UC Davis Medical Center, Sacramento3 trials

Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.

Stroke clinical trials in California: common questions

How many Stroke clinical trials are recruiting in California?
TrialFinder currently lists 62 recruiting Stroke clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Stroke clinical trials located in California?
Study sites for the Stroke trials listed on this page include Arcadia, Los Angeles, Downey, San Francisco, La Jolla, Pomona. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Stroke clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Stroke trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Stroke clinical trial in California?
Each study sets its own criteria based on age, Stroke diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
My stroke was years ago. Are there still trials for me?
Yes. Many recovery trials enroll people six months or more after a stroke, and some accept strokes from many years earlier, because they study whether therapy can still improve movement or speech.
What are stroke rehabilitation trials like?
Intensive and hands-on: therapy sessions several times a week for one to three months, sometimes with a device or stimulation added, and assessments before and after. The comparison group usually gets standard therapy or the program at a later date.
Can a family member join a trial if they cannot consent for themselves?
Some trials allow a legally authorized representative to consent on a participant's behalf, particularly acute and prevention studies; most rehabilitation trials need the participant's own consent and active participation. Ask the study team.
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Stroke trials cover thrombolytic agents, mechanical thrombectomy techniques, neuroprotective drugs, and intensive rehabilitation programmes for acute and chronic stroke.

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