44 Recruiting Trials

Clinical Trials
for Stroke in Massachusetts

44 clinical trials for Stroke are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.

44
Recruiting trials
23
Study sites
7
Cities
11
Industry-sponsored
4
Phase 2
6
Phase 3

Stroke clinical trials in Massachusetts: what to expect

Stroke trials come in three kinds. Acute treatment trials enroll within hours of a stroke, inside the hospital, and are not something you apply to. Recovery and rehabilitation trials enroll from a few weeks to many years after a stroke and test intensive therapy, robotics, brain and nerve stimulation, virtual reality and medicines meant to help the brain rewire. Prevention trials test blood thinners, cholesterol and blood pressure treatments and procedures to lower the chance of a second stroke.

In Massachusetts, recruiting stroke studies are concentrated in Boston, Charlestown, Springfield and Worcester, with sites in 3 other cities. 11 of the 44 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who stroke trials usually look for

Listings state the time since stroke, the type (a clot or a bleed) and the kind of difficulty they study, such as arm and hand weakness, walking, speech or vision, often with a range on a standard scale that the study therapist scores. Many recovery trials enroll people six months or more after their stroke, so an older stroke does not rule you out. Prevention trials look for a stroke or mini-stroke in a recent window plus a specific risk factor such as atrial fibrillation. Most require that you can give consent and take part in sessions.

What taking part involves

Rehabilitation trials are intensive: several sessions a week for four to twelve weeks, with assessments by a therapist before, after and some months later, and sometimes an MRI. The comparison group often receives standard therapy or the same program later. Prevention trials are long and light: a study medicine or placebo added to usual care, visits every few months for several years. Study care and equipment are free and travel is usually reimbursed; a family member is welcome at visits.

Questions worth asking the study team

How many sessions are required and where; whether a comparison group receives the therapy later; whether current rehabilitation can continue; what the assessments involve; and whether transport can be arranged.

Showing 20 of 44 recruiting Stroke trials in Massachusetts

Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
PHASE2 Fairhope, Alabama +4 sites NCT05065216
This trial is looking for adults who have had a moderate stroke and present within 24 hours of the onset. Participants will receive a study medication to see if it helps improve their condition.
Recruiting
Novel Wrist Sensor System to Promote Hemiparetic Arm Use in Home Daily Life of Chronic Stroke Survivors
PHASE2 Boston, Massachusetts NCT05626894
This trial is looking for people who have had a stroke and have difficulty using one arm. Participants will use a device called StrokeWear along with a home exercise plan for 6 months.
Recruiting
Telerehabilitation In The Home After Stroke
NA Downey, California +4 sites NCT06682429
This trial is looking for people who have arm weakness from a stroke that happened 90 to 150 days ago. Participants will receive telerehabilitation to improve their arm function, alongside usual care, for 6 weeks.
Recruiting
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
NA Tucson, Arizona +4 sites NCT03821129
This trial is looking for patients who have had a recent stroke and also have a condition called Patent Foramen Ovale (PFO). Participants will receive a device to help reduce the risk of future strokes.
Recruiting
Pilot/Pivotal Study of DBS+Rehab After Stroke
NA Boston, Massachusetts +4 sites NCT05701280
This trial is looking for people who had a stroke and still have weakness in their arm. Participants will receive treatment to help improve their arm function.
Recruiting
Mechanisms of Open and Hidden Placebo in Stroke Recovery
NA Cambridge, Massachusetts NCT05832567
This trial is looking for adults with weakness on one side of their body due to a stroke that happened at least 6 months ago. Participants will help researchers understand how placebos might help in recovery.
Recruiting
Relying on Pharmacotherapy to Improve Motor Gains in Chronic Stroke Survivors
EARLY_PHASE1 Charlestown, Massachusetts NCT07588932
This trial is looking for stroke survivors aged 21 to 80 who want to improve their movement after rehabilitation. Those who join will take specific medications along with robot-assisted therapy to help in their recovery.
Recruiting
At Home Wearable Sensors and Smartphone for Stroke Survivors With Upper Limb Motor Challenges.
NA Charlestown, Massachusetts NCT06787729
This trial is looking for stroke survivors aged 18 to 80 who have difficulty using one arm. Participants will wear sensors and use a smartphone app to help improve arm use in daily activities.
Recruiting
Fall Risk Intervention for Stroke
NA Boston, Massachusetts NCT07349030
This trial is looking for patients who are in the hospital after having a stroke. Participants will receive extra help to prevent falls and will be asked about any falls they have after leaving the hospital.
Recruiting
Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors
NA Boston, Massachusetts +1 sites NCT07414732
This trial is looking for stroke survivors who want to improve their medication adherence. Participants will receive support through phone exercises, a weekly pill organizer, and reminders to take their medications.
Recruiting
Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors
NA Boston, Massachusetts NCT02896348
This trial is looking for people who have had a stroke at least 6 months ago and have difficulty using their affected hand. Participants will use a device at home to help improve their hand movement compared to standard therapy.
Recruiting
PostureCheck: A Vision-based Compensatory-posture-detection Tool for Robot-assisted Upper-limb Therapy
NA Charlestown, Massachusetts NCT04851886
This trial is looking for people who have had a stroke and need help with arm recovery. Participants will receive robot-assisted therapy either one-on-one or in small groups while their exercise performance is tracked by a camera system.
Recruiting
Substrates for Post-Stroke Arm Rehabilitation
NA Boston, Massachusetts NCT06998485
This trial is looking for individuals who have had a stroke and have trouble moving their arm. Participants will undergo a 6-week arm training program to help improve their movement.
Recruiting
BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement
NA Boston, Massachusetts NCT07091851
This trial is looking for people who have had a stroke and high blood pressure. Participants will test two methods to help lower their blood pressure: checking it at home and learning about blood pressure in a group.
Recruiting
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
N/A Birmingham, Alabama +4 sites NCT05911568
This trial is looking for adults who had a stroke and have moderate to severe disability before it. Participants will compare two treatment options: a procedure to remove blood clots or regular medical care without the procedure.
Recruiting
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
N/A Birmingham, Alabama +4 sites NCT05338697
This trial is looking for adults who have had a stroke and are experiencing motor difficulties in one arm. Participants will undergo specific tests and procedures to help researchers understand recovery outcomes.
Recruiting
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
N/A Boston, Massachusetts +4 sites NCT00682695
This trial is looking for adults who have had a hemorrhagic stroke. Participants will provide consent for interviews, blood pressure checks, and blood sampling.
Recruiting
Stroke Thrombectomy and Aneurysm Registry
N/A Birmingham, Alabama +4 sites NCT04994756
This trial is looking for patients undergoing surgery for brain injuries. Participants will help collect information about their treatment and outcomes.
Recruiting
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
PHASE3 Mobile, Alabama +4 sites NCT05611242
This trial is looking for adults aged 18 to 79 who have had an acute ischemic stroke. Participants will receive a specific treatment for blocked arteries in the brain to see if it's more effective than other approaches.
Recruiting

Where the Stroke studies are in Massachusetts

  • Massachusetts General Hospital, Boston18 trials
  • Boston Medical Center, Boston7 trials
  • Tufts Medical Center, Boston4 trials
  • Baystate Medical Center, Springfield3 trials
  • Beth Israel Deaconess Medical Center, Boston3 trials
  • Brigham and Women's Hospital, Boston3 trials

Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.

Stroke clinical trials in Massachusetts: common questions

How many Stroke clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 44 recruiting Stroke clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Stroke clinical trials located in Massachusetts?
Study sites for the Stroke trials listed on this page include Boston, Cambridge, Charlestown. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Stroke clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Stroke trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Stroke clinical trial in Massachusetts?
Each study sets its own criteria based on age, Stroke diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
My stroke was years ago. Are there still trials for me?
Yes. Many recovery trials enroll people six months or more after a stroke, and some accept strokes from many years earlier, because they study whether therapy can still improve movement or speech.
What are stroke rehabilitation trials like?
Intensive and hands-on: therapy sessions several times a week for one to three months, sometimes with a device or stimulation added, and assessments before and after. The comparison group usually gets standard therapy or the program at a later date.
Can a family member join a trial if they cannot consent for themselves?
Some trials allow a legally authorized representative to consent on a participant's behalf, particularly acute and prevention studies; most rehabilitation trials need the participant's own consent and active participation. Ask the study team.
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Stroke trials cover thrombolytic agents, mechanical thrombectomy techniques, neuroprotective drugs, and intensive rehabilitation programmes for acute and chronic stroke.

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