No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 99
Sex
Any
Study type
Interventional
Purpose
Health Services Research
Participants needed
150 (estimated)
Sponsor
Massachusetts General Hospital · Other
Who this trial is looking for
This trial is looking for stroke survivors who want to improve their medication adherence. Participants will receive support through phone exercises, a weekly pill organizer, and reminders to take their medications.
Are You a Good Fit for This Trial?
Must be takingAntihypertensives
You may be able to join if
I am between 18 and 99 years old.
I have had a stroke in the past 12 months.
I am currently prescribed blood pressure medication.
I have not been following my medication plan well.
I can manage my medications on my own.
I speak enough English to participate.
I have a phone that can receive text messages.
I can use one pharmacy for my medications.
You may not be able to join if
I take more than three medication doses a day.
I have a complex medication plan with additional medications.
I have secondary hypertension or other blood pressure issues.
I have physical issues that prevent me from using a pill organizer.
I do not have a stable living situation.
I have moderate-to-severe cognitive impairment or dementia.
I am allergic to the blood pressure monitor or pill organizer.
I am already taking part in another study for medication adherence.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors.
The main questions it aims to answer are:
* Can the Savvy tool improve medication adherence in stroke survivors compared to usual care?
* Does the use of the Savvy tool lead…
The goal of this study is to test if Savvy, a multimodal intervention (consisting of psychological exercises, a weekly pill organizer, and a text message reminder system) can improve medication adherence in stroke survivors.
The main questions it aims to answer are:
* Can the Savvy tool improve medication adherence in stroke survivors compared to usual care?
* Does the use of the Savvy tool lead to better blood pressure control after a stroke?
The investigators will compare the use of the Savvy intervention to a control group that receives usual care, including a package of educational materials.
The study consists of the following components:
* Participants will receive the Savvy intervention or usual care. The intervention package consists of short psychological exercises over the phone, a weekly medication organizer to support daily medication intake, and text message reminders to take medication and refill the medication box. Participants in the control group will receive usual care, including educational materials about the importance of blood pressure and medication.
* All participants will receive a free home blood pressure monitor and will be requested to measure their blood pressure at certain time points during the study.
* Participants will be enrolled in the study for 6 months and will have virtual follow-up calls at 3 and 6 months.
Trial Locations
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Eligibility Criteria
Inclusion criteria:
1. Participants must be between the ages of 18 years old and 99 years old at the time of consent.
2. Self-reported primary diagnosis of stroke (ischemic or hemorrhagic) within the past 12 months, without structural, traumatic or secondary causes (including aneurysm, arteriovenou…
Inclusion criteria:
1. Participants must be between the ages of 18 years old and 99 years old at the time of consent.
2. Self-reported primary diagnosis of stroke (ischemic or hemorrhagic) within the past 12 months, without structural, traumatic or secondary causes (including aneurysm, arteriovenous malformation, or tumor).
3. Currently prescribed an antihypertensive regimen.
4. Currently less than optimal adherence to medication, defined as a score \<25 on the Medication Adherence Report Scale (MARS-5).
5. Cognitively able to manage medications independently, defined as a score of \>4 on the Six-Item Screener (SIS) for cognitive impairment.
6. Speaks English sufficiently to complete consent and study procedures.
7. Has access to a phone that can receive text messages and is able to participate in scheduled phone-based follow-up assessments.
8. Uses, or willing to start using, a single pharmacy chain for prescription refills and is willing to provide consent for the study team to contact the pharmacy to retrieve prescription refill data.
9. Willing and able to provide informed consent.
Exclusion criteria:
1. Prescribed a more than three scheduled daily medication doses.
2. Prescribed a complex medication regimen requiring more than five additional oral medications per dose time.
3. Diagnosed with secondary hypertension or other BP conditions not managed with standard oral antihypertensives.
4. Has upper extremity impairments or other physical limitations that prevent safe use of the medication box or BP monitor.
5. Lives in an environment where the medication organizer cannot be safely or consistently accessed, such as in temporary housing, shelters, or unstable living conditions.
6. Diagnosed with moderate-to-severe cognitive impairment, dementia, or active psychiatric instability that precludes informed consent or reliable participation.
7. Known allergy or contraindication to the materials used in the BP monitor or the medication box.
8. Participation in another intervention trial targeting medication adherence or BP control.
9. Planned relocation or anticipated unavailability for the 12-month study period.
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