Clinical Trials
for Alzheimer's in Massachusetts
50 clinical trials for Alzheimer's are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.
Alzheimer's clinical trials in Massachusetts: what to expect
Alzheimer's trials now span the whole course of the disease. Prevention studies enroll people with normal memory who have early signs of amyloid in the brain; treatment studies enroll people with mild cognitive impairment or early Alzheimer's and test the next generation of antibodies, tau-targeting drugs and combinations; and symptom studies address agitation, sleep and depression in later stages. Alongside drugs there are trials of exercise, cognitive training, blood tests for diagnosis and support programs for care partners.
In Massachusetts, recruiting alzheimer's studies are concentrated in Boston, Newton, Watertown and Springfield, with sites in 13 other cities. 25 of the 50 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who Alzheimer's trials usually look for
Most drug trials enroll ages 50 to 85 and define a stage with a memory test score range, then confirm Alzheimer's with an amyloid PET scan, a spinal fluid test or, increasingly, a blood test, all done by the study. Nearly every trial requires a study partner: someone who knows you well, attends visits and answers questions about daily life. Common exclusions are another cause of memory loss, a recent stroke and, for antibody trials, some blood thinners or MRI findings. Prevention trials enroll people with no symptoms at all.
What taking part involves
Screening is longer than for most conditions, often several visits over a few weeks with memory testing, an MRI and an amyloid test. Antibody trials then involve an infusion or injection every two to four weeks, regular safety MRIs and visits for eighteen months to four years, with an extension in which everyone receives the drug. Lifestyle trials involve classes or coaching for six to twenty-four months. All study care is free and travel is usually reimbursed for you and your partner.
Questions worth asking the study team
Whether you will be told your amyloid or genetic results; what the MRI safety monitoring involves; how much time the study partner must give; whether there is an extension after the placebo period; and what happens if memory worsens during the study.
Showing 20 of 50 recruiting Alzheimer's trials in Massachusetts
Where the Alzheimer's studies are in Massachusetts
- Massachusetts General Hospital, Boston7 trials
- Boston Center for Memory, Newton6 trials
- Adams Clinical Boston, Boston3 trials
- Adams Clinical Watertown, Watertown3 trials
- Hopeful Aging, Winchester2 trials
- Local Institution - 2615, Worcester2 trials
Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.
Alzheimer's clinical trials in Massachusetts: common questions
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