Alzheimer's Trials / Trials in California
65 Recruiting Trials

Clinical Trials
for Alzheimer's in California

65 clinical trials for Alzheimer's are currently recruiting participants at study sites in California. Study-related care is provided at no cost.

65
Recruiting trials
141
Study sites
46
Cities
42
Industry-sponsored
23
Phase 2
21
Phase 3

Alzheimer's clinical trials in California: what to expect

Alzheimer's trials now span the whole course of the disease. Prevention studies enroll people with normal memory who have early signs of amyloid in the brain; treatment studies enroll people with mild cognitive impairment or early Alzheimer's and test the next generation of antibodies, tau-targeting drugs and combinations; and symptom studies address agitation, sleep and depression in later stages. Alongside drugs there are trials of exercise, cognitive training, blood tests for diagnosis and support programs for care partners.

In California, recruiting alzheimer's studies are concentrated in Los Angeles, Irvine, Anaheim and Long Beach, with sites in 42 other cities. 42 of the 65 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who Alzheimer's trials usually look for

Most drug trials enroll ages 50 to 85 and define a stage with a memory test score range, then confirm Alzheimer's with an amyloid PET scan, a spinal fluid test or, increasingly, a blood test, all done by the study. Nearly every trial requires a study partner: someone who knows you well, attends visits and answers questions about daily life. Common exclusions are another cause of memory loss, a recent stroke and, for antibody trials, some blood thinners or MRI findings. Prevention trials enroll people with no symptoms at all.

What taking part involves

Screening is longer than for most conditions, often several visits over a few weeks with memory testing, an MRI and an amyloid test. Antibody trials then involve an infusion or injection every two to four weeks, regular safety MRIs and visits for eighteen months to four years, with an extension in which everyone receives the drug. Lifestyle trials involve classes or coaching for six to twenty-four months. All study care is free and travel is usually reimbursed for you and your partner.

Questions worth asking the study team

Whether you will be told your amyloid or genetic results; what the MRI safety monitoring involves; how much time the study partner must give; whether there is an extension after the placebo period; and what happens if memory worsens during the study.

Showing 20 of 65 recruiting Alzheimer's trials in California

A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease
PHASE3 Irvine, California +4 sites NCT07717411
This trial is looking for people who show signs of Alzheimer's disease but are currently not experiencing cognitive impairment. Participants will receive treatment and help researchers understand its effects on preventing further progression of Alzheimer's.
Recruiting
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
PHASE3 Fullerton, California +4 sites NCT06976203
This trial is looking for people with Alzheimer's disease who are experiencing cognitive impairment. Participants will take the medications KarXT and KarX-EC and attend scheduled visits with a caregiver throughout the study.
Recruiting
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
PHASE3 Garden Grove, California +4 sites NCT07011745
This trial is looking for adults with agitation related to Alzheimer's Disease. Participants will receive a treatment and will be asked to have their caregiver attend visits and help with the study.
Recruiting
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
PHASE3 Long Beach, California +4 sites NCT06976216
This trial is looking for people with mild to moderate Alzheimer's disease who want to help test a new treatment. Participants will need a caregiver to support them and attend study visits.
Recruiting
A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease
PHASE2 Oakland, California +4 sites NCT07688213
This trial is looking for people aged 55 to 85 with mild Alzheimer's disease or mild cognitive impairment. Participants will take a daily pill and might continue in the study for up to 111 weeks.
Recruiting
A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
PHASE1 Irvine, California +4 sites NCT07599670
This trial is looking for people with Alzheimer's disease to test a new drug called ABBV-1758. Participants will receive injections of the drug or a placebo every 4 weeks for 24 weeks.
Recruiting
A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease
PHASE2 Irvine, California +4 sites NCT07094516
This trial is looking for people aged 50 to 85 with early Alzheimer's disease. Participants will take VHB937 for up to 72 weeks and will have regular visits with a study partner.
Recruiting
A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early Alzheimer's Disease After Multiple Dose Administration
PHASE1 Anaheim, California +4 sites NCT07780383
This trial is looking for healthy adults and people with early Alzheimer's disease. Participants will take a single or multiple doses of the drug BMS-986446 to help researchers understand its effects and safety.
Recruiting
Transcranial Photobiomodulation (tPBM) in Alzheimer's Disease Study
NA Los Angeles, California NCT07224607
This trial is looking for people aged 55 to 89 with memory problems related to Alzheimer's disease. Participants will receive a special light treatment on their forehead and undergo cognitive tests and blood sample collection before and after the treatment.
Recruiting
ACP-204 in Adults With Alzheimer's Disease Psychosis
PHASE2 Anaheim, California +4 sites NCT06159673
This trial is looking for adults aged 55 to 95 who have Alzheimer's disease psychosis. Participants will receive either ACP-204 or a placebo for six weeks, with follow-up visits to check on their health afterwards.
Recruiting
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
PHASE3 Imperial, California +4 sites NCT07177352
This trial is looking for individuals who may qualify for Alzheimer's disease research studies. Participants will be assessed to see if they can join related interventional studies.
Recruiting
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
PHASE3 Homewood, Alabama +4 sites NCT05980949
This trial is looking for people who have completed previous studies on KarXT for Alzheimer's-related psychosis. Participants will take KarXT for a year to help researchers understand its long-term safety and tolerability.
Recruiting
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
PHASE3 Anaheim, California +4 sites NCT06126224
This trial is looking for men and women aged 55 to 90 who have Alzheimer's disease along with symptoms like hallucinations or delusions. They need to have a stable living situation and a trusted person who sees them regularly. However, people with certain other mental health conditions or serious medical issues will not be eligible to participate.
Recruiting
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
PHASE3 Encino, California +4 sites NCT05511363
This trial is looking for older adults with psychosis associated with Alzheimer's Disease. Participants will be randomly assigned to receive either KarXT or a placebo for 38 weeks, with regular visits to monitor their condition.
Recruiting
Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia
PHASE2 Murrieta, California +4 sites NCT07284472
This trial is looking for adults aged 55 to 90 with Alzheimer's disease dementia who experience significant agitation. Participants will be evaluated to see how safe and effective the treatments EXV-802 and EXV-801 are for reducing their agitation.
Recruiting
A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
PHASE3 Irvine, California +4 sites NCT07169578
This trial is looking for people with early Alzheimer's disease symptoms. Participants will take part in tests to evaluate their memory and cognitive abilities while receiving treatment.
Recruiting
A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
PHASE3 Imperial, California +4 sites NCT07170150
This trial is looking for people with early symptoms of Alzheimer's disease. Participants will take a medication called trontinemab and go through tests like imaging and assessments to see how well the treatment works and if it is safe.
Recruiting
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
PHASE2 La Jolla, California +4 sites NCT05552157
This trial is looking for adults aged 18 and older who have a specific genetic mutation linked to early Alzheimer's disease or have a family history of it, but are not showing any signs of cognitive decline yet. They also ask that women who could become pregnant use effective birth control during the study. If someone has significant health issues or cannot communicate in the approved language, they won’t be able to participate.
Recruiting
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
PHASE2 La Jolla, California +4 sites NCT06647498
This trial is looking for adults at risk for Alzheimer's disease caused by genetic mutations. If eligible, I will take a study drug and undergo various tests to help assess its effects on the disease.
Recruiting
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
PHASE2 Irvine, California +4 sites NCT07033494
This trial is looking for people with early Alzheimer's disease who want to help researchers learn if a new treatment called MK-2214 can help slow down brain changes. Participants will take MK-2214 or a placebo and be monitored for safety and effects.
Recruiting
See all 65 Alzheimer's trials in California

Where the Alzheimer's studies are in California

Research sites running the most studies
  • Healthy Brain Clinic, Long Beach6 trials
  • Syrentis Clinical Research, Santa Ana5 trials
  • Irvine Center for Clinical Research, Irvine4 trials
  • Irvine Clinical Research, Irvine4 trials
  • Oakland Clinical, Oakland4 trials
  • Advanced Research Center, Inc., Anaheim3 trials
By city

Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.

Alzheimer's clinical trials in California: common questions

How many Alzheimer's clinical trials are recruiting in California?
TrialFinder currently lists 65 recruiting Alzheimer's clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Alzheimer's clinical trials located in California?
Study sites for the Alzheimer's trials listed on this page include Irvine, Fullerton, Garden Grove, Long Beach, Oakland, Anaheim. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Alzheimer's clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Alzheimer's trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Alzheimer's clinical trial in California?
Each study sets its own criteria based on age, Alzheimer's diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Do I need an Alzheimer's diagnosis to join a trial?
No. Prevention trials enroll people with normal memory and test them for early amyloid, and many treatment trials accept people with memory concerns who have not been formally diagnosed, then confirm the diagnosis as part of screening.
What is a study partner?
A family member or close friend who attends visits with you and answers questions about memory and daily activities. Nearly every Alzheimer's trial requires one, and their time is usually reimbursed too.
Will I learn my amyloid or APOE results?
Many trials now disclose amyloid status, since it decides eligibility, and explain what it means. Genetic results are disclosed in some trials and not others; ask before you consent.
Alzheimer's Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Alzheimer's Trials

Alzheimer's disease trials test amyloid-clearing antibodies, tau inhibitors, lifestyle interventions, and early-detection biomarkers for dementia prevention and treatment.

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