31 Recruiting Trials
Clinical Trials
for Multiple Sclerosis in California
31 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in California. Study-related care is provided at no cost.
31
Recruiting trials
38
Study sites
18
Cities
18
Industry-sponsored
6
Phase 2
8
Phase 3
Multiple Sclerosis clinical trials in California: what to expect
Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.
In California, recruiting multiple sclerosis studies are concentrated in San Francisco, Palo Alto, West Hollywood and La Jolla, with sites in 14 other cities. 18 of the 31 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who multiple sclerosis trials usually look for
Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.
What taking part involves
Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.
Questions worth asking the study team
What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.
Showing 20 of 31 recruiting Multiple Sclerosis trials in California
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Recruiting
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Recruiting
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Recruiting
This trial is looking for children and adolescents with relapsing remitting multiple sclerosis (MS). Participants will take either ozanimod or fingolimod and help researchers understand how well these treatments work and their effects on the body.
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
Recruiting
This trial is looking for adults with two types of Multiple Sclerosis called primary progressive or secondary progressive MS. Participants will receive a treatment called TRX319 and will undergo tests to check the treatment's safety and effectiveness over about a year.
Hyperpolarized Carbon Metabolic Imaging in Multiple Sclerosis
Recruiting
This trial is looking for adults with relapsing remitting multiple sclerosis who have not been treated with disease-modifying therapies for at least two years. Participants will undergo imaging and assessments to help understand how their disease is progressing and how they might respond to a specific therapy.
Obe-cel in Refractory Progressive Forms of Multiple Sclerosis
Recruiting
This trial is looking for adults with progressive multiple sclerosis that has not responded to previous treatments. Participants will receive chemotherapy followed by a single infusion of obe-cel and will be monitored for safety and effectiveness.
A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis
Recruiting
This trial is looking for adults aged 18 to 65 with multiple sclerosis that is progressive or not relapsing. Participants will receive a specific cell therapy and need to meet various health criteria.
Entire-body PET Scans for Multiple Sclerosis
Recruiting
This trial is looking for people with multiple sclerosis or healthy volunteers. Participants will undergo an imaging scan that lasts between 10 to 20 minutes while lying still.
Central Vein Sign in Multiple Sclerosis Extension Study
Recruiting
This trial is looking for people who are already part of the CAVS-MS study and have completed their 24-month visits. Participants will be followed for 48 months to see how two specific MRI markers help in diagnosing and monitoring multiple sclerosis.
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Recruiting
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Care in Multiple Sclerosis (MS)
Recruiting
This trial is looking for individuals with relapsing-remitting multiple sclerosis, particularly from Black, Hispanic, or low-income backgrounds. Participants will take part in interviews and assessments to understand how childhood experiences and environment affect their health and quality of life.
MS-ResearchBiomarkerS
Recruiting
This trial is looking for people with Multiple Sclerosis or related conditions. Participants will be involved in assessments using visual tests and MRI scans to help understand disability progression.
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
Recruiting
This trial is looking for adults with treatment-resistant multiple sclerosis. Participants will be randomly assigned to receive either stem cell transplantation or the best available therapy and will be followed for 6 years.
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Recruiting
This trial is looking for people with relapsing multiple sclerosis who have been treated with ocrelizumab and want to switch to remibrutinib. Participants will take remibrutinib and their health will be monitored.
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Recruiting
This trial is looking for people with Primary Progressive Multiple Sclerosis (PPMS). Participants will take either the study drug orelabrutinib or a placebo for about 30 to 60 months, with at least 12 months of treatment.
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Recruiting
This trial is looking for people with Secondary Progressive Multiple Sclerosis who have not had a clinical relapse for at least 2 years. Participants will receive either orelabrutinib or a placebo for 1 to 5 years.
The SetPoint System as a Pro-Remyelination Therapy for Relapsing-Remitting Multiple Sclerosis: A Pilot Study
Recruiting
This trial is looking for adults with relapsing-remitting multiple sclerosis (RRMS) to test a new device. Participants will have a small device placed under their skin in a procedure to see if it helps with their condition.
Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy
Recruiting
This trial is looking for adults with relapsing remitting multiple sclerosis to see if clemastine fumarate can help repair damage in the brain. Participants will undergo multiple MRI assessments and must meet specific health criteria to join.
A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk
Recruiting
This trial is looking for breastfeeding women who are being treated with BRIUMVI™ for relapsing multiple sclerosis. Participants will provide breast milk for testing during the study.
Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)
Recruiting
This trial is looking for women who are pregnant, planning to become pregnant, or have recently given birth and have certain neurological conditions. Participants will provide small samples like blood and breast milk and complete surveys to help researchers understand how pregnancy affects health.
Where the Multiple Sclerosis studies are in California
Research sites running the most studies
- Cedars-Sinai Medical Center, Los Angeles2 trials
- Hoag Memorial Hospital Presbyterian, Newport Beach2 trials
- Stanford Multiple Sclerosis Center, Palo Alto2 trials
- TG Therapeutics Investigational Trial Site, Orange2 trials
- University of California San Francisco, San Francisco2 trials
- University of California, San Francisco, San Francisco2 trials
By city
Counts are recruiting studies listing at least one site in California, from ClinicalTrials.gov, refreshed every two days.
Multiple Sclerosis clinical trials in California: common questions
How many Multiple Sclerosis clinical trials are recruiting in California?
TrialFinder currently lists 31 recruiting Multiple Sclerosis clinical trials with study sites in California. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in California?
Study sites for the Multiple Sclerosis trials listed on this page include Loma Linda, La Jolla, San Francisco, Palo Alto, Ladera Ranch, Los Angeles. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in California?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in California also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in California?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
Multiple Sclerosis Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Multiple Sclerosis Trials
MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.
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