Multiple Sclerosis Trials / Trials in Colorado
15 Recruiting Trials

Clinical Trials
for Multiple Sclerosis in Colorado

15 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in Colorado. Study-related care is provided at no cost.

15
Recruiting trials
20
Study sites
8
Cities
9
Industry-sponsored
2
Phase 2
4
Phase 3

Multiple Sclerosis clinical trials in Colorado: what to expect

Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.

In Colorado, recruiting multiple sclerosis studies are concentrated in Aurora, Fort Collins, Denver and Basalt, with sites in 4 other cities. 9 of the 15 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who multiple sclerosis trials usually look for

Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.

What taking part involves

Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.

Questions worth asking the study team

What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.

Showing 15 of 15 recruiting Multiple Sclerosis trials in Colorado

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
PHASE3 Birmingham, Alabama +4 sites NCT07225504
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Recruiting
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
PHASE3 Cullman, Alabama +4 sites NCT07325292
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Recruiting
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
PHASE2 Aurora, Colorado +4 sites NCT06782490
This trial is looking for people with multiple sclerosis (MS) who experience muscle stiffness for at least 6 months. Participants will help evaluate the safety and effectiveness of a new treatment.
Recruiting
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
PHASE1 Aurora, Colorado +4 sites NCT07224373
This trial is looking for adults with multiple sclerosis to test a new treatment called AZD0120. Participants will need to provide consent and meet specific health criteria to join the study.
Recruiting
Blood Flow Restriction And Veterans With MS
NA Aurora, Colorado NCT05433103
This trial is looking for veterans with multiple sclerosis (MS) who have advanced disability. Participants will engage in a strength training program that uses a special device to improve muscle strength with lower intensity exercise.
Recruiting
Reducing Fatigue in People With Multiple Sclerosis by Treatment With TENS
NA Boulder, Colorado NCT05500963
This trial is looking for people with multiple sclerosis who are experiencing fatigue. Participants will receive treatment using a method called TENS to help reduce their fatigue levels.
Recruiting
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
N/A Birmingham, Alabama +4 sites NCT06433752
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Recruiting
Care in Multiple Sclerosis (MS)
N/A Aurora, Colorado +4 sites NCT07011914
This trial is looking for individuals with relapsing-remitting multiple sclerosis, particularly from Black, Hispanic, or low-income backgrounds. Participants will take part in interviews and assessments to understand how childhood experiences and environment affect their health and quality of life.
Recruiting
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
PHASE3 Aurora, Colorado +4 sites NCT04047628
This trial is looking for adults with treatment-resistant multiple sclerosis. Participants will be randomly assigned to receive either stem cell transplantation or the best available therapy and will be followed for 6 years.
Recruiting
Home Based Infusions for Ocrelizumab
PHASE4 Centennial, Colorado NCT04650321
This trial is looking for people with Multiple Sclerosis who can receive ocrelizumab infusions at home. Participants will have a diagnosis of MS and must currently be treated at the Rocky Mountain MS Center.
Recruiting
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
N/A Aurora, Colorado +4 sites NCT05658497
This trial is looking for women with multiple sclerosis who are pregnant or planning to become pregnant. Participants will share information about their use of Vumerity and other treatments during their pregnancy.
Recruiting
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
PHASE3 Fort Collins, Colorado +4 sites NCT05877963
This trial is looking for people with relapsing multiple sclerosis. Participants will receive a modified treatment of ublituximab and help researchers understand its effectiveness and safety.
Recruiting
Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod
PHASE4 Aurora, Colorado +2 sites NCT06529406
This trial is looking for people with relapsing multiple sclerosis who have been stable and treated with a specific therapy for at least two years. Participants will switch to a different medication called ozanimod and will have regular check-ups during the trial.
Recruiting
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
PHASE2 Aurora, Colorado +4 sites NCT07002034
This trial is looking for people who have been diagnosed with Adjustment Disorder due to cancer or certain other health conditions. Participants will receive a single dose of the study drug to see if it helps reduce their depressive or anxiety symptoms.
Recruiting
A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101
N/A Denver, Colorado NCT07403188
This trial is looking for people who have previously received KYV-101 treatment. Participants will help researchers understand the long-term effects of this treatment.
Recruiting
See all 15 Multiple Sclerosis trials in Colorado

Where the Multiple Sclerosis studies are in Colorado

Research sites running the most studies
  • University of Colorado Anschutz Medical Campus, Aurora2 trials
  • Advanced Neurology of Colorado- Site Number : 8400148, Fort Collins1 trial
  • Amerita, Centennial1 trial
  • Local Institution - 0017, Aurora1 trial
  • Research Site, Aurora1 trial
  • Rocky Mountain Multiple Sclerosis Center, University of Colorado School of Medicine, Aurora1 trial
By city

Counts are recruiting studies listing at least one site in Colorado, from ClinicalTrials.gov, refreshed every two days.

Multiple Sclerosis clinical trials in Colorado: common questions

How many Multiple Sclerosis clinical trials are recruiting in Colorado?
TrialFinder currently lists 15 recruiting Multiple Sclerosis clinical trials with study sites in Colorado. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in Colorado?
Study sites for the Multiple Sclerosis trials listed on this page include Aurora, Boulder, Centennial, Fort Collins, Denver. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in Colorado?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in Colorado also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in Colorado?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
Multiple Sclerosis Trials in Other States
Alabama Alaska Arizona Arkansas California Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Multiple Sclerosis Trials

MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.

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