Multiple Sclerosis Trials / Trials in Massachusetts
26 Recruiting Trials

Clinical Trials
for Multiple Sclerosis in Massachusetts

26 clinical trials for Multiple Sclerosis are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.

26
Recruiting trials
31
Study sites
9
Cities
11
Industry-sponsored
7
Phase 2
7
Phase 3

Multiple Sclerosis clinical trials in Massachusetts: what to expect

Multiple sclerosis trials divide into relapsing and progressive forms. Relapsing MS studies test new oral and infused disease-modifying therapies, usually against an approved medicine rather than a placebo. Progressive MS has fewer approved options, so trials there test drugs meant to slow disability, protect nerves or repair myelin, and often do use a placebo. Alongside these are trials of rehabilitation, exercise, diet, fatigue and bladder treatments, and studies that simply follow people over time with MRI and blood tests.

In Massachusetts, recruiting multiple sclerosis studies are concentrated in Boston, Foxborough, Worcester and Burlington, with sites in 5 other cities. 11 of the 26 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who multiple sclerosis trials usually look for

Listings state the type of MS, an age range (commonly 18 to 55 for relapsing trials, up to 65 for progressive) and a disability score range measured by the study neurologist. Relapsing trials usually want a relapse or new MRI activity in the past one to two years. Drug trials require a washout from your current therapy, which varies from weeks to months by drug and is managed by the site. Symptom and rehabilitation trials let you stay on your treatment.

What taking part involves

Screening includes a neurological exam, blood work and an MRI. Drug trials then run one to three years with visits every one to three months, an MRI every six to twelve months and a relapse assessment whenever symptoms change. Relapses are treated as normal. The study drug, scans and visits are free, and an extension usually lets everyone continue the active treatment afterwards. Rehabilitation trials involve sessions over eight to twenty-four weeks with walking, hand and cognition tests.

Questions worth asking the study team

What the comparison treatment is; how the washout from your current therapy is handled and how long it lasts; how many MRIs are needed; whether there is an extension; and what happens if you relapse during the study.

Showing 20 of 26 recruiting Multiple Sclerosis trials in Massachusetts

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
PHASE3 Birmingham, Alabama +4 sites NCT07225504
This trial is looking for adults aged 18-65 with secondary progressive multiple sclerosis (SPMS). Participants will take the medication remibrutinib and have regular assessments to evaluate its effects.
Recruiting
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
PHASE3 Cullman, Alabama +4 sites NCT07325292
This trial is looking for adults between 18 to 60 years old with Multiple Sclerosis. Participants will receive frexalimab either by injection under the skin or through an IV every four weeks for a year.
Recruiting
Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis
PHASE3 Boston, Massachusetts NCT06136728
This trial is looking for people with multiple sclerosis who have difficulty walking. If you join, you'll take a medication called dalfampridine for 6 weeks, have a break from it, and participate in a 6-week physical therapy program.
Recruiting
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
PHASE2 Birmingham, Alabama +4 sites NCT06782490
This trial is looking for people with multiple sclerosis (MS) who experience muscle stiffness for at least 6 months. Participants will help evaluate the safety and effectiveness of a new treatment.
Recruiting
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
PHASE2 Boston, Massachusetts +4 sites NCT06735248
This trial is looking for people aged 18 to 55 with multiple sclerosis. Participants will receive either the study drug, mRNA-1195, or a placebo while being monitored for safety and side effects.
Recruiting
Molecular Imaging of NET Using [C-11]MRB-PET in MS
PHASE1 Boston, Massachusetts NCT03207464
This trial is looking for people with Multiple Sclerosis to understand brain injury better. Participants will undergo brain scans using a special imaging technique called PET and will answer questions about their health.
Recruiting
PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases
PHASE1 Boston, Massachusetts NCT02649985
This trial is looking for adults with Multiple Sclerosis or Alzheimer's Disease who are willing to undergo brain imaging tests. Participants will help researchers understand brain changes related to these conditions compared to healthy individuals.
Recruiting
Nasal Foralumab in Patients With Non-Active Secondary Progressive Multiple Sclerosis
PHASE2 Boston, Massachusetts NCT06890923
This trial is looking for people who have recently completed another study on nasal foralumab and have been diagnosed with non-active secondary progressive multiple sclerosis. Participants will take the treatment for six months and may have their dose increased based on their health status during the study.
Recruiting
Glucose Consumption in MS Using [F-18]FDG-PET
PHASE4 Boston, Massachusetts NCT07087106
This trial is looking for people with multiple sclerosis and healthy individuals to help understand how glucose is used in the brain. Participants will undergo imaging tests with PET and MRI to compare brain activity and health.
Recruiting
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
PHASE1 Boston, Massachusetts NCT04699747
This trial is looking for adults aged 18 to 65 with multiple sclerosis or healthy volunteers. Participants will receive an imaging agent called 18F 3F4AP and undergo assessments to see how it works in the brain.
Recruiting
Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
NA Boston, Massachusetts NCT06554340
This trial is looking for people with multiple sclerosis and high blood pressure to see if home cycling exercise can improve their blood pressure, thinking skills, and walking abilities. Participants will try either cycling or stretching exercises for 12 weeks and visit the lab twice for tests.
Recruiting
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
N/A Birmingham, Alabama +4 sites NCT06433752
This trial is looking for people with a confirmed diagnosis of relapsing multiple sclerosis who are starting treatment with BRIUMVI®. Participants will receive the medication and share their experiences and results during the study.
Recruiting
Genes and Environment in Multiple Sclerosis
N/A Boston, Massachusetts +4 sites NCT01353547
This trial is looking for people who might be at risk for multiple sclerosis due to genetics or other factors. Participants will help researchers understand these risks better, which could lead to ways to prevent or treat the disease.
Recruiting
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
N/A Boston, Massachusetts NCT04603196
Recruiting
Care in Multiple Sclerosis (MS)
N/A Boston, Massachusetts +4 sites NCT07011914
This trial is looking for individuals with relapsing-remitting multiple sclerosis, particularly from Black, Hispanic, or low-income backgrounds. Participants will take part in interviews and assessments to understand how childhood experiences and environment affect their health and quality of life.
Recruiting
IConquerMS™ - a Patient-Powered Research Network for Multiple Sclerosis
N/A Waltham, Massachusetts NCT02486562
Recruiting
A Single-Center Study to Characterize the Safety and Efficacy of Ublituximab in Older Adults With Relapsing Forms of Multiple Sclerosis (RMS)
N/A Foxborough, Massachusetts NCT06681623
Recruiting
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
PHASE3 Worcester, Massachusetts +4 sites NCT04047628
This trial is looking for adults with treatment-resistant multiple sclerosis. Participants will be randomly assigned to receive either stem cell transplantation or the best available therapy and will be followed for 6 years.
Recruiting
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
PHASE3 Scottsdale, Arizona +4 sites NCT06846281
This trial is looking for people with relapsing multiple sclerosis who have been treated with ocrelizumab and want to switch to remibrutinib. Participants will take remibrutinib and their health will be monitored.
Recruiting
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
PHASE3 Phoenix, Arizona +4 sites NCT07299019
This trial is looking for people with Secondary Progressive Multiple Sclerosis who have not had a clinical relapse for at least 2 years. Participants will receive either orelabrutinib or a placebo for 1 to 5 years.
Recruiting
See all 26 Multiple Sclerosis trials in Massachusetts

Where the Multiple Sclerosis studies are in Massachusetts

Research sites running the most studies
  • Massachusetts General Hospital, Boston4 trials
  • Brigham and Women's Hospital, Boston3 trials
  • TG Therapeutics Investigational Trial Site, Boston3 trials
  • Brigham MS Center, 60 Fenwood Road, Boston2 trials
  • University of Massachusetts Memorial Medical Center, Worcester2 trials
  • Accelerated Cure Project, Waltham1 trial
By city

Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.

Multiple Sclerosis clinical trials in Massachusetts: common questions

How many Multiple Sclerosis clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 26 recruiting Multiple Sclerosis clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Multiple Sclerosis clinical trials located in Massachusetts?
Study sites for the Multiple Sclerosis trials listed on this page include Boston, Waltham, Foxborough, Worcester. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Multiple Sclerosis clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Multiple Sclerosis trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Multiple Sclerosis clinical trial in Massachusetts?
Each study sets its own criteria based on age, Multiple Sclerosis diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I get a placebo instead of MS treatment?
In relapsing MS almost never: trials compare the new drug with an approved medicine, so everyone is treated. Progressive MS trials more often use a placebo because fewer approved treatments exist, and an extension usually follows.
Do I need to stop my current MS medicine to join?
For a drug trial, yes, after a washout that depends on your current medicine and is supervised by the study neurologist. Trials of rehabilitation, diet or symptom treatments let you continue it.
What is an EDSS score?
The Expanded Disability Status Scale, a 0 to 10 score a neurologist assigns from an exam, mostly based on walking. Trials set a range, and the study neurologist scores you at screening; you do not need to know it in advance.
Multiple Sclerosis Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Multiple Sclerosis Trials

MS trials investigate disease-modifying therapies, remyelination strategies, stem-cell transplants, and neuroprotective agents for relapsing and progressive forms of MS.

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