No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
80 (estimated)
Sponsor
University of Massachusetts, Boston · Other
Who this trial is looking for
This trial is looking for people with multiple sclerosis and high blood pressure to see if home cycling exercise can improve their blood pressure, thinking skills, and walking abilities. Participants will try either cycling or stretching exercises for 12 weeks and visit the lab twice for tests.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with multiple sclerosis.
I have high blood pressure.
I am not physically active.
I weigh less than 40 kg/m2.
I am not confined to a wheelchair.
I have not had a multiple sclerosis relapse in the past 30 days.
I am on stable medication.
You may not be able to join if
I have other heart problems.
I have type 1 diabetes.
My doctor does not approve my participation.
I do not have enough space for a stationary bike at home.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-based stretching program.
The main questions this study aims to answer are:
1. Can home-based cycli…
The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-based stretching program.
The main questions this study aims to answer are:
1. Can home-based cycling exercise training improve blood pressure by increasing blood vessel dilation in people with multiple sclerosis?
2. Can cycling exercise training improve cognition and walking mobility in people with multiple sclerosis by improving blood pressure?
The investigators will compare home-based cycling training to stretching to see if cycling training improves cognition, walking mobility, blood pressure, and fitness in people with multiple sclerosis.
Participation in this study will take 13-14 weeks, with participants being randomized (like flipping a coin, a 50-50 chance of being in either group) to the home-based cycling training or the stretching group.
All participants will be asked to
* Visit the laboratory two times, one before the beginning of the intervention (home-base training and stretching group) and one at the end of the intervention.
* During visits, participants will complete tests related to cognition, walking mobility, blood pressure and fitness.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis;
* Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial sy…
Inclusion Criteria:
* Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis;
* Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure \> 120 mmHg or brachial diastolic blood pressure \> 80 mmHg)
* Persons who are physically inactive (less than 60 min/wk of physical activity);
* Persons with body mass index \< 40 kg/m2;
* Persons who are not confined to a wheel chair;
* Multiple sclerosis relapse in the past 30 days;
* People with stable pharmacotherapy.
Exclusion Criteria:
* People with additional cardiovascular comorbidities;
* People with type 1 diabetes mellitus;
* Physician disapproval to participating in the study;
* Space constraints to fit a cycle ergometer at the home of prospective participants.
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