29 Recruiting Trials
Clinical Trials
for Heart Disease in Massachusetts
29 clinical trials for Heart Disease are currently recruiting participants at study sites in Massachusetts. Study-related care is provided at no cost.
29
Recruiting trials
14
Study sites
4
Cities
12
Industry-sponsored
1
Phase 2
3
Phase 3
Heart Disease clinical trials in Massachusetts: what to expect
Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.
In Massachusetts, recruiting heart disease studies are concentrated in Boston, Springfield, Needham and Worcester. 12 of the 29 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.
Who heart disease trials usually look for
Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.
What taking part involves
Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.
Questions worth asking the study team
Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.
Showing 20 of 29 recruiting Heart Disease trials in Massachusetts
BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
Recruiting
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
Recruiting
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures
Recruiting
This trial is looking for children and young adults with congenital heart disease who are undergoing non-cardiac procedures. Participants will help researchers understand the risks and healthcare needs for these patients.
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
Recruiting
This trial is looking for newborns diagnosed with severe congenital heart disease who will have surgery at Boston Children's Hospital during their first week of life. Participating involves giving a blood sample to help researchers understand why some babies have issues with blood clotting.
Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease
Recruiting
This trial is looking for patients with congenital heart disease who are having a cardiac MRI. Participants will have their heart scanned using MRI to help understand heart scar tissue better.
Lumason® Infusion vs. Bolus Administrations
Recruiting
This trial is looking for adults with heart health issues to compare two ways of giving a heart imaging substance called Lumason®. Participants will receive either a continuous drip or a quick injection of Lumason®.
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Recruiting
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Allogeneic Valve Transplantation
Recruiting
This trial is looking for patients who need a new heart valve and might benefit from using valves from donated hearts. Taking part involves potential travel to the transplant center and staying in touch for follow-up care.
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
Recruiting
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
Recruiting
This trial is looking for infants under 6 months who have a congenital heart defect that needs a special stent to help blood flow. Parents or legal representatives will need to give consent for their child to participate.
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
Recruiting
This trial is looking for people who experience chest pain or shortness of breath to find out if these symptoms are due to a heart issue. Participants will undergo a special heart imaging test during exercise-like conditions to measure blood flow to the heart.
Autus Valve Continued Access Study (CAS)
Recruiting
This trial is looking for children aged 18 months to 16 years who need surgery to replace their pulmonary valve. Participants will have regular check-ups over 10 years to see how well the Autus Valve works as they grow.
Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children
Recruiting
This trial is looking for children under 12 years old who have had heart surgery and are on a ventilator for more than 48 hours. Participants will be monitored to see if a special support system helps reduce the time they need mechanical ventilation.
Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
Recruiting
This trial is looking for patients of all ages who are scheduled for complex heart surgery using a heart-lung machine. Participants will have their blood tested before, during, and after the surgery to study immune responses.
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
Recruiting
This trial is looking for teens aged 12-17 with congenital heart disease. Participants will take part in a 5-week online program that aims to help them improve their ability to handle stress and live better lives.
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Recruiting
This trial is looking for patients with heart failure and pulmonary hypertension. Participants will receive a specific treatment and be monitored for three years to evaluate safety and effectiveness.
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
Recruiting
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Recruiting
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Transition to KPL-387 Monotherapy Dosing & Administration Study
Recruiting
This trial is looking for adults who have a recent history of well-controlled recurring chest pain caused by inflammation around the heart. They should have been treated with certain medications for at least three months and currently be stable on those treatments. However, people with certain infections, recent serious illnesses, or specific other health issues are not eligible to join.
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
Recruiting
This trial is looking for adults with significant calcium build-up in their coronary arteries. Participants will undergo imaging tests to see if a specific method helps improve treatment outcomes.
Where the Heart Disease studies are in Massachusetts
Research sites running the most studies
- Boston Children's Hospital, Boston14 trials
- Massachusetts General Hospital, Boston5 trials
- Beth Israel Deaconess Medical Center, Boston3 trials
- Brigham and Women's Hospital, Boston3 trials
- Baystate Health, Springfield2 trials
- Beth Israel Deaconess, Boston1 trial
By city
Counts are recruiting studies listing at least one site in Massachusetts, from ClinicalTrials.gov, refreshed every two days.
Heart Disease clinical trials in Massachusetts: common questions
How many Heart Disease clinical trials are recruiting in Massachusetts?
TrialFinder currently lists 29 recruiting Heart Disease clinical trials with study sites in Massachusetts. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Massachusetts?
Study sites for the Heart Disease trials listed on this page include Boston. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Massachusetts?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Massachusetts also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Massachusetts?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
All guides →
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials
Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.
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