Heart Disease Trials / Trials in Maryland
17 Recruiting Trials

Clinical Trials
for Heart Disease in Maryland

17 clinical trials for Heart Disease are currently recruiting participants at study sites in Maryland. Study-related care is provided at no cost.

17
Recruiting trials
13
Study sites
3
Cities
5
Industry-sponsored
2
Phase 2
1
Phase 3

Heart Disease clinical trials in Maryland: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Maryland, recruiting heart disease studies are concentrated in Baltimore, Bethesda and College Park. 5 of the 17 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 17 of 17 recruiting Heart Disease trials in Maryland

Cord Clamping Among Neonates With Congenital Heart Disease
NA Birmingham, Alabama +4 sites NCT06153459
This trial is looking for pregnant individuals whose babies have been diagnosed with congenital heart disease. Participants will be randomly assigned to have their baby's umbilical cord clamped either 30 seconds or 120 seconds after birth and will complete assessments at various ages to monitor outcomes.
Recruiting
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
N/A Baltimore, Maryland +4 sites NCT06932081
This trial is looking for adults with congenital heart defects who have started treatment with SGLT2 inhibitors. Participation involves allowing researchers to collect data on how these drugs affect heart health and safety.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
CORE-COMPARE Pilot Study
NA Baltimore, Maryland NCT06170541
This trial is looking for people aged 21 to 85 with signs of coronary heart disease. Participants will help researchers understand if a new scanning technology is better at identifying this condition than standard scans.
Recruiting
Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
N/A Bethesda, Maryland NCT05213598
This trial is looking for adults who have had the Fontan procedure and are at risk for liver disease. Participants will undergo tests and procedures to help understand liver scarring and find new treatments.
Recruiting
New Heart Imaging Techniques to Evaluate Possible Heart Disease
NA Bethesda, Maryland NCT01399385
This trial is looking for people aged 18 and older who may have heart disease or are healthy volunteers. Participants will undergo various heart imaging tests, including MRI scans, to help improve heart disease diagnosis.
Recruiting
Diabetes and Heart Disease Risk in Blacks
N/A Bethesda, Maryland NCT00001853
This trial is looking for Black adults aged 18 to 70 who are healthy, to study the link between body size and heart disease risk. Participants will share information about their health and undergo some tests.
Recruiting
Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study
N/A Bethesda, Maryland +1 sites NCT06730113
This trial is looking for young people aged 12 to 25 with type 2 diabetes, those who are overweight, and healthy lean individuals. Participants will attend annual visits at the NIH clinic for up to 25 years and undergo various health tests.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
Focused Orticumab Research for Treating Inflammation in Coronary Arteries
PHASE2 Los Angeles, California +4 sites NCT06927739
This trial is looking for participants with a history of heart attack and high levels of coronary inflammation. Taking part involves receiving either orticumab or a placebo for 6 months while continuing regular doctor visits.
Recruiting
Cooperative Assessment of Late Effects for SCD Curative Therapies
N/A Baltimore, Maryland +4 sites NCT05153967
This trial is looking for individuals with Sickle Cell Disease (SCD) to study the long-term effects of new treatments. Participants will provide health information before and after treatment to help understand the outcomes.
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
PHASE3 La Jolla, California +4 sites NCT06563895
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Recruiting
Transition to KPL-387 Monotherapy Dosing & Administration Study
PHASE2 Phoenix, Arizona +4 sites NCT07288216
This trial is looking for adults who have a recent history of well-controlled recurring chest pain caused by inflammation around the heart. They should have been treated with certain medications for at least three months and currently be stable on those treatments. However, people with certain infections, recent serious illnesses, or specific other health issues are not eligible to join.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NA Gilbert, Arizona +4 sites NCT03142152
This trial is looking for individuals with heart failure and a specific type of mitral valve problem. Participants will be randomly assigned to receive either the treatment or a control and will need to attend follow-up visits.
Recruiting
CTSN Embolic Protection Trial
NA North Little Rock, Arkansas +4 sites NCT06027788
This trial is looking for patients aged 60 and older who are scheduled for certain types of heart valve surgeries. By participating, I would be helping to test a device designed to protect the heart during the procedure.
Recruiting
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
PHASE1 Bethesda, Maryland NCT05904093
This trial is looking for adults aged 18 to 65 with stable sickle cell disease. Participants will take a medication called fostamatinib at home for up to 6 weeks and have regular check-ups to monitor their health and any side effects.
Recruiting
See all 17 Heart Disease trials in Maryland

Where the Heart Disease studies are in Maryland

Research sites running the most studies
  • National Institutes of Health Clinical Center, Bethesda6 trials
  • Johns Hopkins University, Baltimore3 trials
  • University of Maryland Medical Center, Baltimore2 trials
  • Abcentra Investigational Site, Baltimore1 trial
  • Investigational Site 025, Baltimore1 trial
  • Johns Hopkins, Baltimore1 trial
By city

Counts are recruiting studies listing at least one site in Maryland, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Maryland: common questions

How many Heart Disease clinical trials are recruiting in Maryland?
TrialFinder currently lists 17 recruiting Heart Disease clinical trials with study sites in Maryland. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Maryland?
Study sites for the Heart Disease trials listed on this page include Baltimore, Bethesda. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Maryland?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Maryland also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Maryland?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

Check Your Eligibility

Create a free profile and our AI will match you to Heart Disease trials near you in Maryland.

Get Matched — Free
No insurance required
About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

All Heart Disease trials →
Other Conditions in Maryland
Diabetes Cancer Breast Cancer Depression Anxiety Alzheimer's Asthma Multiple Sclerosis Obesity Parkinson's Lupus Hypertension COPD Stroke Arthritis Kidney Disease COVID-19
All trials in Maryland →