Heart Disease Trials / Trials in Ohio
46 Recruiting Trials

Clinical Trials
for Heart Disease in Ohio

46 clinical trials for Heart Disease are currently recruiting participants at study sites in Ohio. Study-related care is provided at no cost.

46
Recruiting trials
33
Study sites
8
Cities
16
Industry-sponsored
3
Phase 2
3
Phase 3

Heart Disease clinical trials in Ohio: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Ohio, recruiting heart disease studies are concentrated in Cleveland, Cincinnati, Columbus and Akron, with sites in 4 other cities. 16 of the 46 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 20 of 46 recruiting Heart Disease trials in Ohio

Comparative Imaging Assessment of Valvular Heart Disease
N/A Cleveland, Ohio NCT04126018
This trial is looking for adults who have certain heart valve conditions. Participants will undergo various imaging tests to help gather information about their heart's function and condition.
Recruiting
BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
NA Phoenix, Arizona +4 sites NCT07582848
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Recruiting
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
NA Phoenix, Arizona +4 sites NCT07582861
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Recruiting
Cord Clamping Among Neonates With Congenital Heart Disease
NA Birmingham, Alabama +4 sites NCT06153459
This trial is looking for pregnant individuals whose babies have been diagnosed with congenital heart disease. Participants will be randomly assigned to have their baby's umbilical cord clamped either 30 seconds or 120 seconds after birth and will complete assessments at various ages to monitor outcomes.
Recruiting
Genetics of Congenital Heart Disease
N/A Columbus, Ohio NCT01192048
This trial is looking for people with congenital heart disease or their family members. Participants will help researchers find the genetic causes of this condition.
Recruiting
Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease
N/A Columbus, Ohio +2 sites NCT06952933
This trial is looking for adults who have congenital heart disease and want to help researchers learn about the connection between heart health, psychological trauma, and PTSD. Participants will complete surveys online to share their experiences and feelings.
Recruiting
Heart Institute Biobank & Registry for Adult Congenital Heart Disease and Related Disorders
N/A Cincinnati, Ohio NCT07477197
This trial is looking for adults who have congenital heart disease or related health issues. Participants will help provide samples and information to support future health research.
Recruiting
Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables
N/A Cleveland, Ohio NCT06818760
Recruiting
Pathways to Prevention Food-is-Medicine Trial
NA Columbus, Ohio NCT07380243
This trial is looking for families with a parent who has a high BMI and a child between 6 to 11 years old. Participants will receive support to improve their heart health through access to healthy food, nutrition education, and coaching.
Recruiting
Sternal Plating High Risk
NA Cleveland, Ohio NCT06660186
This trial is looking for adults with heart disease who are having open heart surgery. Participants will help compare two methods for closing the sternum after surgery.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
Abbott Structural Heart Device Registry
N/A Los Angeles, California +4 sites NCT06590467
This trial is looking for patients who need or have had heart device implants. Participants will help gather information about the safety and performance of specific heart devices used in hospitals.
Recruiting
IPSC Repository of Pediatric Cardiovascular Disease
N/A Columbus, Ohio NCT05550324
This trial is looking for children who have heart diseases or related syndromes. Participants will provide blood samples to help researchers learn more about these conditions and improve treatments.
Recruiting
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
PHASE3 Phoenix, Arizona +4 sites NCT05918211
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Recruiting
Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
NA Los Angeles, California +4 sites NCT07114718
This trial is looking for infants under 6 months who have a congenital heart defect that needs a special stent to help blood flow. Parents or legal representatives will need to give consent for their child to participate.
Recruiting
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
NA San Francisco, California +4 sites NCT06854458
This trial is looking for people who experience chest pain or shortness of breath to find out if these symptoms are due to a heart issue. Participants will undergo a special heart imaging test during exercise-like conditions to measure blood flow to the heart.
Recruiting
Autus Valve Continued Access Study (CAS)
NA Los Angeles, California +4 sites NCT07466745
This trial is looking for children aged 18 months to 16 years who need surgery to replace their pulmonary valve. Participants will have regular check-ups over 10 years to see how well the Autus Valve works as they grow.
Recruiting
Effect of Fetal Aortic Valvuloplasty on Outcomes
N/A Columbus, Ohio +4 sites NCT05386173
This trial is looking for pregnant individuals with fetuses diagnosed with a severe heart condition known as hypoplastic left heart syndrome. Participants will be evaluated for a special treatment that involves balloon dilation to help improve heart function before birth.
Recruiting
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
NA Stanford, California +4 sites NCT07525843
This trial is looking for teens aged 12-17 with congenital heart disease. Participants will take part in a 5-week online program that aims to help them improve their ability to handle stress and live better lives.
Recruiting
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
NA Tucson, Arizona +4 sites NCT07214376
This trial is looking for patients with heart failure and pulmonary hypertension. Participants will receive a specific treatment and be monitored for three years to evaluate safety and effectiveness.
Recruiting
See all 46 Heart Disease trials in Ohio

Where the Heart Disease studies are in Ohio

Research sites running the most studies
  • Cleveland Clinic, Cleveland14 trials
  • Nationwide Children's Hospital, Columbus11 trials
  • Cincinnati Children's Hospital Medical Center, Cincinnati5 trials
  • Children's Hospital Medical Center, Cincinnati, Cincinnati3 trials
  • Cleveland Clinic Foundation, Cleveland3 trials
  • The Cleveland Clinic Foundation, Cleveland3 trials
By city

Counts are recruiting studies listing at least one site in Ohio, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Ohio: common questions

How many Heart Disease clinical trials are recruiting in Ohio?
TrialFinder currently lists 46 recruiting Heart Disease clinical trials with study sites in Ohio. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Ohio?
Study sites for the Heart Disease trials listed on this page include Cleveland, Columbus, Cincinnati. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Ohio?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Ohio also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Ohio?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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