Heart Disease Trials / Trials in Kentucky
10 Recruiting Trials

Clinical Trials
for Heart Disease in Kentucky

10 clinical trials for Heart Disease are currently recruiting participants at study sites in Kentucky. Study-related care is provided at no cost.

10
Recruiting trials
10
Study sites
2
Cities
3
Industry-sponsored
2
Phase 2

Heart Disease clinical trials in Kentucky: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Kentucky, recruiting heart disease studies are concentrated in Louisville and Lexington. 3 of the 10 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 10 of 10 recruiting Heart Disease trials in Kentucky

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
NA Phoenix, Arizona +4 sites NCT07582848
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Recruiting
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
NA Phoenix, Arizona +4 sites NCT07582861
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Recruiting
Single or Repeated Intravenous Administration of umbiliCAl Cord Mesenchymal sTrOmal Cells in Ischemic Cardiomyopathy
PHASE2 Louisville, Kentucky +2 sites NCT06145035
This trial is looking for adults aged 21 to 85 with ischemic heart disease. Participants will receive stem cells from umbilical cords to see if this treatment is safe and effective for improving heart function.
Recruiting
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
NA Louisville, Kentucky +4 sites NCT06854458
This trial is looking for people who experience chest pain or shortness of breath to find out if these symptoms are due to a heart issue. Participants will undergo a special heart imaging test during exercise-like conditions to measure blood flow to the heart.
Recruiting
A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study
NA Lexington, Kentucky +4 sites NCT07525843
This trial is looking for teens aged 12-17 with congenital heart disease. Participants will take part in a 5-week online program that aims to help them improve their ability to handle stress and live better lives.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
Focused Orticumab Research for Treating Inflammation in Coronary Arteries
PHASE2 Louisville, Kentucky +4 sites NCT06927739
This trial is looking for participants with a history of heart attack and high levels of coronary inflammation. Taking part involves receiving either orticumab or a placebo for 6 months while continuing regular doctor visits.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NA Phoenix, Arizona +4 sites NCT06526195
This trial is looking for patients with advanced heart failure who are not dependent on intravenous medications. Participants will be evaluated to see if a device called HeartMate 3 can help their heart function better compared to standard medical treatments.
Recruiting
ATrial Tachycardia PAcing Therapy in Congenital Heart
N/A Los Angeles, California +4 sites NCT03209583
This trial is looking for people with congenital heart disease who have an atrial arrhythmia and an implanted atrial anti-tachycardia device where the therapy is active. Participants will help researchers understand how effective this treatment is for their condition.
Recruiting
See all 10 Heart Disease trials in Kentucky

Where the Heart Disease studies are in Kentucky

Research sites running the most studies
  • Golisano Children's at UK, Lexington2 trials
  • University of Kentucky, Lexington2 trials
  • Abcentra Investigational Site, Louisville1 trial
  • Norton Children's Hospital, Louisville1 trial
  • Norton Healthcare, Louisville1 trial
  • Norton Hospital, Louisville1 trial
By city

Counts are recruiting studies listing at least one site in Kentucky, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Kentucky: common questions

How many Heart Disease clinical trials are recruiting in Kentucky?
TrialFinder currently lists 10 recruiting Heart Disease clinical trials with study sites in Kentucky. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Kentucky?
Study sites for the Heart Disease trials listed on this page include Louisville, Lexington. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Kentucky?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Kentucky also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Kentucky?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming
Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
All guides →

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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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