Heart Disease Trials / Trials in Illinois
18 Recruiting Trials

Clinical Trials
for Heart Disease in Illinois

18 clinical trials for Heart Disease are currently recruiting participants at study sites in Illinois. Study-related care is provided at no cost.

18
Recruiting trials
20
Study sites
8
Cities
8
Industry-sponsored
1
Phase 2
2
Phase 3

Heart Disease clinical trials in Illinois: what to expect

Heart disease trials cover heart failure, coronary artery disease, atrial fibrillation, high cholesterol and lipoprotein(a), and the devices and procedures used to treat them. The largest are outcomes trials: thousands of people take a study medicine or placebo on top of their usual treatment for several years while the trial counts heart attacks, strokes and hospital stays. Smaller studies test new heart failure drugs, cholesterol-lowering injections given a few times a year, cardiac rehabilitation programs and monitoring devices.

In Illinois, recruiting heart disease studies are concentrated in Chicago, Downers Grove, Glenview and Naperville, with sites in 4 other cities. 8 of the 18 are run by a drug or device company, which usually means a larger study with travel reimbursement; the rest are academic or hospital-led.

Who heart disease trials usually look for

Listings define the condition precisely: an ejection fraction range for heart failure, a heart attack or stent within a recent window, cholesterol still above target on a statin, or a lipoprotein(a) level above a threshold. They usually ask that your current heart medicines have been stable for a month or more. Common exclusions are a very recent procedure, advanced kidney disease and another illness that limits life expectancy. Ages generally run from 18 with no upper limit.

What taking part involves

Screening includes an ECG, blood work and often an echocardiogram. Outcomes trials are long but light: a pill or injection added to your treatment, visits every three to six months and phone check-ins between. Drug trials for heart failure run three to twelve months with monthly visits. Device trials involve a procedure and follow-up imaging. Your existing heart medicines continue throughout; study treatment and tests are free, and travel is usually reimbursed.

Questions worth asking the study team

Whether anything about your current treatment would change; how long the trial runs and how often you must come in; what is being measured and what you will be told about your own results; and whether your cardiologist will receive updates.

Showing 18 of 18 recruiting Heart Disease trials in Illinois

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
NA Chicago, Illinois +4 sites NCT07582848
This trial is looking for mothers and their infants who have been diagnosed with congenital heart disease. Participants will receive support to help increase direct breastfeeding.
Recruiting
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
NA Chicago, Illinois +4 sites NCT07582861
This trial is looking for pregnant individuals or mothers of infants diagnosed with congenital heart disease (CHD). Participants will receive usual care plus a virtual psychological intervention to help manage their situation.
Recruiting
Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment
NA Chicago, Illinois +4 sites NCT03891160
This trial is looking for children with Congenital Heart Disease who are going to have a ventricular assist device (VAD) placed. Participants will help researchers understand if using a 3D model of their heart can improve surgery outcomes.
Recruiting
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
NA Los Angeles, California +4 sites NCT04124120
This trial is looking for women aged 18 and older who need heart surgery. Participants will help researchers compare two types of artery grafts used in heart operations to see which works better.
Recruiting
Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department
NA Chicago, Illinois NCT06769880
This trial is looking for adults aged 45 and older who have high blood pressure, diabetes, or obesity. Participants will receive education about heart failure, with some getting a quick ultrasound to help understand their health better.
Recruiting
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
PHASE3 Phoenix, Arizona +4 sites NCT05918211
This trial is looking for adolescents aged 12 to under 19 who have had the Fontan procedure. Participants will take either udenafil or a placebo to help assess its safety and effectiveness.
Recruiting
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
N/A Birmingham, Alabama +4 sites NCT02852031
This trial is looking for newborns diagnosed with Hypoplastic Left Heart Syndrome (HLHS) who are meant to have a specific heart surgery called the Norwood procedure. The goal is to gather information to help improve care for these infants.
Recruiting
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
PHASE3 La Jolla, California +4 sites NCT06563895
This trial is looking for adults who carry a specific genetic variant that can lead to a heart condition but have not yet shown any symptoms. Participants will receive an experimental drug called acoramidis to see if it can prevent heart issues.
Recruiting
Transition to KPL-387 Monotherapy Dosing & Administration Study
PHASE2 Phoenix, Arizona +4 sites NCT07288216
This trial is looking for adults who have a recent history of well-controlled recurring chest pain caused by inflammation around the heart. They should have been treated with certain medications for at least three months and currently be stable on those treatments. However, people with certain infections, recent serious illnesses, or specific other health issues are not eligible to join.
Recruiting
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NA Birmingham, Alabama +4 sites NCT06310031
This trial is looking for adults with advanced heart failure to test a device called the BrioVAD System. Participants will receive the BrioVAD and be monitored for safety and effectiveness compared to another treatment.
Recruiting
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NA Phoenix, Arizona +4 sites NCT06526195
This trial is looking for patients with advanced heart failure who are not dependent on intravenous medications. Participants will be evaluated to see if a device called HeartMate 3 can help their heart function better compared to standard medical treatments.
Recruiting
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NA Gilbert, Arizona +4 sites NCT03142152
This trial is looking for individuals with heart failure and a specific type of mitral valve problem. Participants will be randomly assigned to receive either the treatment or a control and will need to attend follow-up visits.
Recruiting
The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
N/A Chicago, Illinois NCT01280825
This trial is looking for patients receiving ongoing care at the University of Chicago. Participants will provide DNA samples to help understand how their genes may affect their medication responses.
Recruiting
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
PHASE4 Chicago, Illinois +4 sites NCT05786417
This trial is looking for older adults with stable angina and multiple health conditions. Participants will take medication to evaluate its effectiveness and side effects.
Recruiting
EFS of the DUO System for Tricuspid Regurgitation
NA Chicago, Illinois +4 sites NCT05913908
This trial is looking for adults with severe tricuspid regurgitation who are still having symptoms despite treatment. Participants will be evaluated for the safety and effectiveness of a new valve system called the DUO System.
Recruiting
The TRICURE EFS Study
NA Chicago, Illinois +4 sites NCT06506942
This trial is looking for adults with severe tricuspid regurgitation who are considered at higher risk for surgery. Participants will be evaluated by a heart team and may receive a new heart valve device.
Recruiting
Paired-Ring Mitral Annuloplasty Ring Sizing Device
N/A Glenview, Illinois NCT06965725
This trial is looking for patients scheduled for mitral repair surgery. If you join, you'll help evaluate a new sizing system used during the procedure.
Recruiting
Transpacific TAVR Registry
N/A Chicago, Illinois +4 sites NCT03826264
This trial is looking for patients who are having a Transcatheter aortic valve replacement (TAVR). To participate, you need to provide informed consent.
Recruiting
See all 18 Heart Disease trials in Illinois

Where the Heart Disease studies are in Illinois

Research sites running the most studies
  • Lurie Children's Hospital, Chicago4 trials
  • University of Chicago, Chicago4 trials
  • Northwestern University, Chicago2 trials
  • Rush University Medical Center, Chicago2 trials
  • Advocate Children's Hospital, Oak Lawn1 trial
  • Advocate Christ Medical Center, Chicago1 trial
By city

Counts are recruiting studies listing at least one site in Illinois, from ClinicalTrials.gov, refreshed every two days.

Heart Disease clinical trials in Illinois: common questions

How many Heart Disease clinical trials are recruiting in Illinois?
TrialFinder currently lists 18 recruiting Heart Disease clinical trials with study sites in Illinois. Results are updated regularly from ClinicalTrials.gov, the official U.S. registry of clinical studies.
Where are Heart Disease clinical trials located in Illinois?
Study sites for the Heart Disease trials listed on this page include Chicago, Glenview. Each trial page lists every participating site with contact details, so you can find the location closest to you.
Do I need insurance to join a Heart Disease clinical trial in Illinois?
No. Study-related care is covered by the trial sponsor at no cost to participants, including the study treatment, required lab tests and study visits. Many Heart Disease trials in Illinois also compensate participants for time and travel. Health insurance is not required to search or enroll.
How do I qualify for a Heart Disease clinical trial in Illinois?
Each study sets its own criteria based on age, Heart Disease diagnosis details, prior treatments, current medications and general health. The fastest way to find out is to contact a research site directly — most will pre-screen you by phone in 10 to 15 minutes at no charge. You can also create a free TrialFinder profile to be matched automatically.
Will I have to stop my heart medicines to join a trial?
Almost never. Heart disease trials add a study treatment to the medicines you already take, and your own cardiologist continues to manage them. A trial that requires a change says so in its listing.
What is a cardiovascular outcomes trial?
A large, multi-year study in which participants take a study medicine or placebo on top of standard care while the trial counts events such as heart attacks and hospital stays. Visits are infrequent, and the drug is provided free throughout.
Can I join a trial after a heart attack or stent?
Yes. Many trials enroll in the weeks after a heart attack or procedure, because that is when the next event is most likely. The window is stated in the listing, so ask soon after discharge.
Heart Disease Trials in Other States
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Helpful Reading
Are Clinical Trials Safe? What Patients Should Know
How clinical trial safety works — phases, IRB oversight, informed consent, and your right to withdraw — plus the real risks and questions to ask.
How to Know If You Qualify for a Clinical Trial
Every trial has eligibility criteria based on diagnosis, age, and medical history. Here's how to tell if you qualify — and what to do if you're not sure.
Clinical Trials Without Insurance: What You Need to Know
Clinical trials cover the cost of study-related care, making them one of the few ways to access treatment without health insurance. Here's what's covered.
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About Heart Disease Trials

Cardiovascular trials study statins, PCSK9 inhibitors, heart failure devices, cardiac rehabilitation protocols, and interventional procedures for coronary artery disease.

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