Beta-Blockers and Calcium Channel Blockers for Stable Angina

LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

Recruiting Phase 4 Interventional Study
Angina Stable Ischemic Heart Disease
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
65 and older
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Supportive Care
Participants needed
741 (estimated)
Sponsor
Yale University · Other
Who this trial is looking for

This trial is looking for older adults with stable angina and multiple health conditions. Participants will take medication to evaluate its effectiveness and side effects.

Are You a Good Fit for This Trial?
Rules you out Acute coronary syndromeHeart failure with reduced ejection fraction

You may be able to join if

  • I am 65 years old or older
  • I have stable ischemic heart disease
  • I have at least 2 other chronic health conditions
  • I plan to start treatment for my heart condition

You may not be able to join if

  • I am currently taking both a beta-blocker and a calcium channel blocker
  • I have significant low blood pressure
  • I have a severe heart block
  • I have severe bradycardia
  • I have severe lung disease
  • I cannot participate in follow-up visits
  • I refused to provide informed consent

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: OLDER ADULTS WITH SIHD AND MCC * Age ≥65 years * ≥ 2 Multiple Chronic Conditions as defined by Centers for Medicare and Medicaid Services (CMS) * Diagnosis of Symptomatic Stable Ischemic Heart Disease with plans to initiate medical therapy identified by at least one of the foll…
Contacts

Michael Nanna, MD

(888) 683-0865

livebetter-trial@yale.edu

CONTACT